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Why Not Explore Trans-NIH Initiatives? Dr. Alicia Dombroski, Director DEA, NIDCR Dr. Pamela McInnes, Director DER, NIDCR Dr. Kevin Hardwick, Chief, Research Training and Career Development Branch, NIDCR Dr. Renée Joskow, Dental Officer, NCRR

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slide2

Dr. Alicia Dombroski, Director DEA, NIDCR

Dr. Pamela McInnes, Director DER, NIDCR

Dr. Kevin Hardwick, Chief, Research Training and Career

Development Branch, NIDCR

Dr. Renée Joskow, Dental Officer, NCRR

Dr. Emily Harris, Chief Translational Genomics Research

Branch, NIDCR

slide3

Session Outline

  • American Recovery and Reinvestment Act
  • (ARRA) Opportunities
  • 2) NIH Office of the Director (OD) Programs
  • 3) Other Trans-NIH Programs
  • 4) New Principal Investigator/Early Stage
  • Investigator Policies
slide5

NIDCR is grateful to President Obama and Congress for the opportunity for NIDCR to play its part in improving the Nation’s health and economy

slide6

American Recovery and Reinvestment Act

(ARRA) Opportunities Overview

Fund the best science while stimulating the economy

  • Recovery Act provides NIH with $10.4 billion for 2 years
  • $8.2 billion to support scientific research priorities
  • $7.4 billion transferred to Institutes and Centers, and

the Common Fund (CF)

  • $800 million to OD, not including CF
slide7

$1 billion for Construction, Repairs and Alterations

  • $300 million for Shared Instrumentation
  • $500 million for NIH buildings and facilities
  • $400 million for Comparative Effectiveness

Research

slide8

HHS.gov/Recovery

Investment in Scientific Research and Facilities:

Support for the construction of new research and

educational facilities as well as groundbreaking

scientific research that will improve the health of

the nation.

funding impact
Funding Impact

Stimulate the economy

Create and preserve jobs

Advance biomedical research

scientific research approach
Scientific Research Approach

Stimulate and accelerate biomedical research with existing mechanisms

Funding additional meritorious RO1s, R21s and R03s that have been peer reviewed and approved by IC Councils

Administrative supplements to accelerate ongoing research

Expand science with new programs

Revisions to extant programs (“Competitive supplements”)

New ARRA NIH-wide programs

New ARRA IC-specific programs

new arra nih wide programs
New ARRA NIH-wide Programs

Challenge Grants

Grand Opportunities (“GO” Grants)

Recruit new faculty to conduct research

Provide summer jobs for high school / college students and teachers to work in science labs

AREA (R15) Grants

Supplements

challenge grants
Challenge Grants

At least $200M total to address priority avenues of research

challenge grants14
Challenge Grants

Up to $500K total costs/year for up to two years

45 Topics identified by NIDCR

10 are high priority *

April 27, 2009 receipt date

CSR cluster review

grand opportunity grants
Grand Opportunity Grants

Grand Opportunity (GO) Grants (at least $200M total):

High impact

Well defined

Large scale

go grants
“GO” Grants

8 Topics identified by NIDCR

Testing Mechanisms of Action Hypotheses in Behavioral and/or Social Interventions

Treatment of Tobacco and Drug Dependence in Multiple Dental Clinics

Validation of Biomarkers of Oral Diseases or Salivary Biomarkers

Detection of Oral Premalignant and Malignant Lesions

Genome-wide studies in Craniofacial, Dental and Oral Conditions: Data Generation, Analysis and Integration

Multidisciplinary Approaches to Craniofacial Regeneration and Preclinical Testing

Oral Cancer Genome Analysis

Human Pain Phenotypes and Pain Circuitry

April 27, 2009 letter of intent receipt date

May 27, 2009 receipt date

IC peer review

administrative supplements
Administrative Supplements

NIDCR Strategic Plan 2009-2013

List of interests on NIDCR website

Priority to requests under $100,000

Receipt date June 1, 2009

Eligible: All mechanisms except Fs, T32, L30/40, R13/U13, R25

Up to $12M to the ARRA supplement program – 65% to the Collaborative Sciences Program

administrative supplements for collaborative science
Administrative Supplements for Collaborative Science

Enable NIDCR-funded investigators to form new collaborations to promote the discovery of novel insights required to achieve significant research advances.

Must be within scope of the approved aims of the parent award.

Existing collaborations not eligible.

Up to $120,000 total direct annual costs for the first collaboration. An additional $60,000 for a second collaborating group.

Term is up to duration of the grant.

Eligible: R01, R15, R37, P01, P50, R42, R44, U01, U19, U54

competing revisions
Competing Revisions

To support a significant expansion of the scope of approved and funded research.

Requests must be consistent with the goals of the Recovery Act.

Up to $10M to the Competing Revision program.

Eligible: All mechanisms except Fs, Ks, T32, L30/40, R13/U13, R25

summer jobs in research for students and teachers
Summer Jobs in Research for Students and Teachers

Engage students and educators in research

Encourage students to pursue research careers

Provide summer internships at NIH-funded laboratories for science teachers

slide21
Notice OD-09-060

To further science of parent research grant

High school and undergrad students

High school, community college teachers, faculty from non-research intensive universities

Dental students allowed

NOT substitute for T35/T32 summer training program

No post-docs

ARRA Summer Student Supplements

new faculty
New Faculty

Core Centers for Enhancing Research Capacity in U.S. Academic Institutions

Newly trained scientists

Start-up packages

Pilot research projects

slide23
RFA OD-09-005

Develop a Center for conducting research in a specific scientific topic or problem

Recruit and hire new tenure-track research faculty to develop and conduct this research

“awards will be directed towards hiring investigators and providing appropriate start-up research resources (e.g., research salary, equipment, and supplies for initiating their research) that will help strengthen or expand the scientific capacity of the Biomedical Research Core Center. ”

Supporting New Faculty Recruitment to Enhance Research Resources through Biomedical Research Core Centers (P30)

core center defined scientific research purpose
Core Centerdefined scientific/research purpose

Salary (75% protected research effort)

Start-up package

Funds for research resources

New independent tenure-track faculty hired and appointed to the Core Center to develop and conduct research projects which fit the purpose/mission of the Center

slide25
$500,000 per year for two years (direct costs)

Salary

Start-up costs, including supplies, equipment and support for technical personnel

Research costs to conduct projects within scientific mission of Center

Joint appointment, with at least 75% protected research time

Priority given to applications offering commitment beyond the 2-year duration of the grant

NIH P30: Supporting New Faculty Development to Enhance Research Productivity through Biomedical Research Core Centers

slide26
New faculty hired through P30

Appointed to independent tenure-track (or equivalent) research position at the Assistant Professor level with at least 75% protected research time

New to the faculty and not previously held a tenure-track research appointment

Record of research training and career development in a research area relevant to the primary mission of the Core Center

NIH P30: Supporting New Faculty Development to Enhance Research Productivity through Biomedical Research Core Centers

slide27
New faculty hired through P30

Receive joint appointment(s) with other academic unit(s) at the institution, allowing access to University-wide research resources and core facilities, and to serve as mentors for graduate programs affiliated with other academic unit(s)

Receive a start-up package, including supplies, equipment and support for technical personnel

NIH P30: Supporting New Faculty Development to Enhance Research Productivity through Biomedical Research Core Centers

ncrr initiatives

NCRR Initiatives

Renée W. Joskow, D.D.S., M.P.H.,FAGDCAPT, U.S. Public Health ServiceDental Officer (Research)Division for Clinical Research ResourcesNational Center for Research Resources

national center for research resources
National Center for Research Resources

NCRR will administer more than $1.6 billion in federal grants in the following areas:$1 billion for construction, repair and renovation of research facilities

$300 million for shared instrumentation and other capital research equipment

Up to $310 million in support of biomedical research priorities

american recovery and reinvestment act arra or recovery act of 2009
American Recovery and Reinvestment Act (ARRA or Recovery Act) of 2009

Four related Funding Opportunity Announcements (FOAs) have been released in response to the Recovery Act

Two for instrumentation

PAR-09-028 Shared Instrumentation (SIG Program)

PAR-09-118 High End Instrumentation (HEI Program)

Two that allow alterations and repairs

RFA-RR-09-008 (supports construction, renovation and repair improvement projects; C06 mechanism)

RFA-RR-09-007 (supports core facilities improvement projects; G20 mechanism)

shared and high end instrumentation program s10 overview
Shared and High-End Instrumentation Program (S10): Overview
  • Unique and critical NIH mechanisms
  • Provide funding in cost-range from $100k to $8.0M
    • SIG Program (funding range $100k to $500k)- PAR-09-028
    • HEI Program (funding range $600k to $8.0M)- PAR-09-118
  • Equipment which is too costly to obtain with regular NIH research grants
  • Highly cost-effective mechanisms
  • Instruments placed in core facilities
  • Shared by an average of 8-10 grantees
high end instrumentation s10
High End Instrumentation (S10)
  • Program Announcement: PAR-09-118
  • Notice update: NOT-RR-09-008
  • Single major item of equipment
  • $600k – $8.0 Million
    • Deadline May 6, 2009
  • One Year
  • No limit on number of applications
  • 3 or more NIH-funded users
  • Approximately $160 Million in FY2010
  • Two levels of review
extramural research facilities improvement program c06
Extramural Research Facilities Improvement Program (C06)
  • To construct, renovate or repair biomedical or behavioral research extramural facilities.
  • Provides $2 – 15M for direct costs that improve non-federal basic and clinical research support
    • No more than 3 applications per institution
    • Project period not to exceed 5 years
extramural research facilities c06
Extramural Research Facilities (C06)

What are the application deadlines?

The receipt date of May 6, 2009, is for projects between $2 million and $5 million.

The receipt date of June 17, 2009, is for projects between $10 million and $15 million.

The receipt date of July 17, 2009, is for projects between $5 million and $10 million.

core facility renovation repair and improvement g20
Core Facility Renovation, Repair and Improvement (G20)
  • To renovate or repair extramural core facilities to support biomedical and/or behavioral research, funded by the U.S. Public Health Service (PHS)
    • A core facility is defined as a centralized shared resource that provides access to instruments or technologies or services, as well as expert consultation to NIH-funded investigators.
    • Deadline for applications is Sept. 17, 2009
    • Budgets between $1 million and $10 million may be requested
    • No more than 2 applications per institution
comparison of g20 and c06 rfas
Comparison of G20 and C06 RFAs

*An institution is defined as an organization with a separate IPF code identifier.

slide37

Comparison of G20 and C06 RFAs (II)

Item

RFA-RR-09-007

(Core facilities)

RFA-RR-09-008

(Construction, etc.)

New construction, and completion of shell space

No

Yes

Receipt date(s)

September 17, 2009

May 6, 2009 ($2 – 5 M)

June 17, 2009 ($10 – 15 M)

July 17, 2009 ($5 – 10 M)

Award start dates

July 2010

December 2009 & April 2010

Green technology & design approaches

Creation/retention of American jobs

Yes

Yes

Yes

Yes

arra recovery act construction programs
ARRA/Recovery Act Construction Programs
  • C06/G20 Applicant Help Videocast

http://videocast.nih.gov/ram/arra032309.ram

  • ARRA RFA and FAQ URLs
    • CO6
      • RFA: http://grants.nih.gov/grants/guide/rfa-files/RFA-RR-09-008.html
      • FAQs: www.ncrr.nih.gov/C06_Q&A.asp
    • G20
      • RFA: http://grants.nih.gov/grants/guide/rfa-files/RFA-RR-09-007.html
      • FAQs: www.ncrr.nih.gov/G20_Q&A.asp
  • NIH Enhancing Peer Review Web site
      • http://enhancing-peer-review.nih.gov/
ncrr challenge grants
NCRR Challenge Grants
  • Bioethics
    • 02-RR-101* Recontact Issues in Genotype and Genome-Wide Association Studies
    • 02-OD(OSP)-103* Ethical Issues Associated with Electronic Sharing of Health Information
  • Comparative Effectiveness Research
    • 05-RR-101* Build CER Capacity Through Education
    • 05-RR-102* Support Pilot CER Projects in Community Settings
  • Enabling Technologies
    • 06-RR-101* Virtual environments for Multidisciplinary and Translational Research
    • 06-RR-102* Infrastructure for Biomedical Knowledge Discovery
ncrr challenge grants ii
NCRR Challenge Grants (II)
  • Information Technology for Utilizing Health Care Data Research
    • 10-RR-101* Information Technology Demonstration Projects Facilitating Secondary Use of Healthcare Data for Research
  • Translational Science
    • 15-RR-101* Applied Translational Technology Development
    • 15-RR-102 Develop a Nationwide Electronic Material Transfer Agreement (MTA) Database System

The application due date is April 27, 2009

competitive revision applications
Competitive Revision Applications

Investigators and U.S. institutions and organizations with active NIH funded investigator-initiated awards (R01, R33, R37, R21, U01) reviewed by the Center for Scientific Review (CSR) to leverage the resources, expertise, and infrastructure of the NCRR centers and center-like programs through significant expansion of the scope or research protocol of approved and funded projects.

Deadlines are: April 21, 2009 or July 10, 2009

centers and center like programs
Centers and Center-like Programs

Animal and Biological Material Resources

Biomedical Technology Research Centers

Clinical and Translational Science Awards

General Clinical Research Centers

Institutional Development Award

National Primate Research Centers

Research Centers in Minority Institutions

Science Education Partnership Awards

administrative supplements for ncrr awards
Administrative Supplements for NCRR Awards

Investigators and U.S. institutions or organizations with active NIH research grants may request administrative supplements for the purpose of accelerating the tempo of scientific research on active grants.

The NCRR administrative supplement application due date is May 18, 2009

Can apply for up to two years of support

administrative supplement priorities
Administrative Supplement Priorities

Administrative Supplements to Advance Translational (T1 & T2) Research

Administrative Supplements for the CTSA Consortium Strategic Goals

Administrative Supplements for Enhancing NCRR Pilot Project Mechanism

Administrative Supplements for Collaborative Community Engagement Research

Administrative Supplements for Research Workforce Development and Dissemination

Administrative Supplements for Science Education and Dissemination

slide45

Estimated Proportions of NCRR ARRA Funding

for Administrative Supplements

ncrr funding opportunities

NCRR Funding Opportunities

http://www.ncrr.nih.gov/research_funding/funding_opportunities/

questions

Questions?

Renée W. Joskow, D.D.S., M.P.H., FAGDCAPT, U.S. Public Health ServiceDental Officer (Research)Division for Clinical Research ResourcesNational Center for Research Resources Joskowr@mail.nih.gov301-435-0961

slide48

NIH and ARRA

Stimulating the economy

Creating and preserving jobs

Advancing biomedical research

Improving people’s health

slide49

NIH Office of the Director Programs:

  • “The NIH Common Fund”
  • Codified into law by 2006 NIH Reform Act
  • Purpose: to support cross-cutting, trans-NIH programs that require participation by at least two NIH Institutes or Centers
  • Typically involves initiatives (RFAs and policy changes) developed by multiple NIH Institutes or Centers
  • Centerpiece is NIH Roadmap for Medical Research
slide50

Main Goals of the NIH Roadmap:

  • Foster high-risk/high-reward research
  • Enable the development of transformative tools and methodologies
  • Fill fundamental knowledge gaps
  • Change academic culture to foster collaboration
slide51

Example Initiatives from the NIH Roadmap:

  • Roadmap Transformative R01 Program
    • NIH Director’s Pioneer and New Innovator Programs (DP1 and DP2)
    • Multiple Principal Investigator Policy Change
    • Clinical and Translational Science Awards
slide52

High-Risk/High-Reward Research:

  • Transformative R01 (T-R01) Program
    • “exceptionally innovative, high risk, original and/or unconventional research with the potential to create new or challenge existing scientific paradigms. Projects must clearly demonstrate potential to produce a major impact in a broad area of biomedical or behavioral research”

Human behavior change

3-dimensional tissue models

Transitions from acute to chronic pain

      • Due Jan 29, 2009; $25 million for up to 60 projects
    • http://grants.nih.gov/grants/guide/rfa-files/RFA-RM-08-029.html
slide53

High-Risk/High-Reward Research:

  • 2) NIH Director’s Pioneer Award (DP1)
    • Purpose: to support individual scientists of exceptional creativity at any career stage who propose pioneering/transforming approaches to major challenges in biomedical and behavioral research
      • “pioneering” = highly innovative approaches that have the potential to produce an unusually high impact on a broad area of biomedical or behavioral research; substantially different from those already being pursued in the investigator’s laboratory or elsewhere
    • Pre-application due Dec 17, 2008; $5 million for up to 10 projects
    • http://grants.nih.gov/grants/guide/pa-files/PAR-09-012.html
slide54

High-Risk/High-Reward Research:

  • 3) NIH Director’s New Innovator Award (DP2)
    • Purpose: to support individual scientists with exceptionally innovative research ideas at early stages of their careers, but without the preliminary data required to fare well in the traditional NIH peer review system
    • Pre-application due Dec 15, 2008; $55.7 million for up to 24 projects
    • http://grants.nih.gov/grants/guide/pa-files/PAR-09-013.html
slide55

Change Academic Culture to Foster Collaborations:

  • 1) Multiple Principal Investigator Policy Change
    • Purpose: to give appropriate credit to significant collaborators on team science and multidisciplinary science projects
    • Established November, 2006: http://grants.nih.gov/grants/guide/notice-files/NOT-OD-07-017.html
    • Available for most grant opportunities (specified in the Funding Opportunity Announcement)
slide56

Change Academic Culture to Foster Collaborations:

  • 2) Clinical and Translational Science Award (CTSA)
    • Purpose: to create a multidisciplinary academic home with research resources for new and established investigators, with the goal of fostering research and collaborations that lead to improvements in patient care
    • Letters of intent due September 14, 2009; Applications due October 14, 2009
    • $20 million for up to 4 awards
    • http://grants.nih.gov/grants/guide/rfa-files/RFA-RM-09-004.html
slide57

The future directions of the NIH Roadmap are uncertain, BUT…

  • Across all of NIH, announcements are calling for creative, innovative, transforming, paradigm-shifting research, and…
  • In general, science is becoming more team-oriented, crossing disciplinary boundaries, and…
  • Each field needs to make opportunities for new investigators in order to keep growing, so…
  • It’s likely that creative team science approaches, for new and established investigators, will continue to be reflected in NIH Roadmap initiatives
other trans nih activities
Other Trans-NIH Activities
  • Genes, Environment, and Health Initiative (GEI)

http://www.gei.nih.gov/

  • NIH Blueprint for Neuroscience Research

http://neuroscienceblueprint.nih.gov/

  • Exceptional, Unconventional Research Enabling Knowledge Acceleration (EUREKA)

http://www.nigms.nih.gov/Research/Mechanisms/EUREKA.htm

slide59

Genes, Environment, and Health Initiative (GEI)

  • Supports research that will lead to understanding genetic contributions and gene-environment interactions in common disease
  • Announced in February 2006
  • 4-year program, with funding for FY07 through FY10
  • Supported by additional funds ($40M/year) allocated to NIH by Congress
slide60

EXPOSURE BIOLOGY PROGRAM

GENETICS PROGRAM

Identify genetic variants

Develop technology and biomarkers

GXE

Human Health and Disease

  • Identifying and characterizing potential genetic variants
  • Statistical methods development
  • Translational studies
  • Environmental stressor monitoring
  • Biological response indicators
gei genetics
GEI Genetics
  • Identifying and characterizing potential genetic variants
    • Genome-wide association studies
    • Replication and fine-mapping studies
    • Functional studies
    • Systems biology approaches
  • Statistical methods development
  • Translational research
genome wide association studies
Genome-wide Association Studies

Shared exposures across studies:

  • Tobacco use
  • Alcohol use

Primary outcomes:

  • Addiction
  • Blood clots in the veins
  • Blood pressure
  • Birth weight & maternal metabolism
  • Chronic obstructive pulmonary disease
  • Coronary heart disease
  • Dental caries
  • Glaucoma
  • Lung cancer
  • Oral clefts
  • Preterm birth
  • Prostate cancer
  • Stroke
  • Type 2 diabetes

GEI funding: RFAs HG-06-014,

HG-06-032, HG-06-033, HG-07-012

Additional funding: NHLBI, NIAAA, NIDA, NIDCR

gei exposure biology
GEI Exposure Biology
  • Environmental stressor monitoring
    • Sensor technologies for environmental exposure assessment
    • Improved measures of diet and physical activity
    • Tools for measuring exposure to psychosocial stress and addictive substances
  • Biologic response indicators
    • Biomarkers and biosensors that reflect alterations in key physiologic pathways after exposure to environmental stressors
slide64

NIH Blueprint for Neuroscience Research

  • Framework to enhance cooperative activities across NIH that support research on the nervous system
  • Confronts challenges too large for any single NIH Institute or Center
  • Develops research tools and infrastructure that serve the entire neuroscience community
blueprint thematic initiatives
Blueprint Thematic Initiatives
  • Neurodegeneration
    • Developing research tools, resources, and training activities to accelerate progress
  • Neurodevelopment
    • Creating, expanding and distributing tools and resources
    • Implementing guidelines for advancing model systems of neurodevelopment
  • Neuroplasticity
    • Developing new tools to monitor and manipulate nervous system plasticity
recent blueprint activities
Recent Blueprint Activities
  • NIH Neuroscience Microarray Consortium
  • Gene Expression Nervous System Atlas
  • NIH Toolbox for Assessment of Neurological and Behavioral Function
  • Recombinase-Expressing Mouse Lines
  • Mouse Archiving and Central Distribution
slide68

Exceptional, Unconventional

Research Enabling Knowledge

Acceleration (EUREKA)

  • Fund exceptionally innovative research that, if successful, will have an unusually high impact
  • Targets investigators: testing novel, unconventional hypotheses; or pursuing major methodological or technical challenges
  • Potential impact of the proposed research substantial: size of the scientific community affected; and the magnitude of the effect on the community
slide69

New Principal Investigator/

Early Stage Investigator Policies

slide70

NIH has strong commitment to support

New Investigators

  • Average age of first R01: 37 in 1980, 42 in 2005
  • 2009 new policy to identify Early Stage Investigators
  • Applications from ESIs given special consideration at

at peer review and for funding

slide71

Definitions:

New Investigator- has not previously competed

successfully as a PD/PI for a significant NIH

independent research award. Exclusions – R00,

R03, R15, R21, R34, R36, R42, R43, R55, R56,

SC2, SC3, Fs, Ks, Ls, Gs, Ss.

Early Stage Investigator (ESI)- PD/PI who qualifies

as a New Investigator and is within 10 years of

completing terminal research degree or medical

residency (or equivalent).

slide72

New Investigators should update eRA Commons profiles

-degree date information

-residency completion date information

-notified by email if eligible

  • Multi-PI grants-all PIs must be ESIs for the application
  • to be given the ESI designation
  • FY2009 NIH expects to fund New Investigators at success
  • Rates equivalent to established investigators
  • The majority of New PIs supported in 2009 will also be
  • ESIs
  • NIH encourages New PIs and ESIs to apply for R01s
slide73

Requesting an Extension of the ESI Period

-lapse in research/training or periods of part-time effort

-reasons may include medical concerns, disability,

family care responsibilities, extended periods of

clinical training, natural disasters, active duty military

service

http://grants.nih.gov/grants/new_investigators/index.htm