Objectives:. Define SIRS, Sepsis, and Septic ShockEpidemiology, PathophysiologyHistory of EGDTRefining EGDTSurviving Sepsis CampaignImplementing EGDT in the EDFocus on AbxGOAL: Clinically Useful, Evidence-Based Guidelines for treating your Septic pts. Definitions. SIRS? HR > 90, Temp > 38 C, RR > 20, WBC > 12Sepsis? SIRS Suspected InfxnSevere Sepsis? End Organ DysfunctionSeptic Shock Hypotension (not responsive to IVF).