Drug Delivery System 藥物投遞系統. 生科系 04 級 黃玫璇 891672 生科系 04 級 許哲源 891659 生科系 04 級 蕭宏展 891631 生科系 04 級 楊淳竣 891625. 藥物釋控系統. 黃玫璇 891672. 藥物釋控系統. 1. 何謂藥物釋控 2. 發展釋控的優點 3. 藥物釋控的種類 A. Diffusion controlled B. Chemically controlled C. Solvent-activated controlled. 藥物釋控系統.
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生科系04級 黃玫璇 891672
生科系04級 許哲源 891659
生科系04級 蕭宏展 891631
生科系04級 楊淳竣 891625
【 Diffusion controlled】
Diffusion through membrane or bulk polymer
【 Chemically controlled】
˙ polymer erosion：
bulk erosion ( combination of erosion and diffusion )
˙ pendent chain
【 Solvent-activated controlled】
˙ osmotic transport of water through semi permeable membrane
˙ water penetration into glassy polymer
【 Stomach/Intestine – Liquid】
【 Capsule edge – Gel 】
【 Capsule center – Dry 】
△release rates are determined by polymer property and partition coefficient of the drug to be released.
˙ drug diffuses out of matrix at defined rate
˙ efficiency of diffusion of large molecules
˙ danger of ‘dose dumping’ in barrier systems
˙ erosion： Surface erosion, Bulk erosion
△ capsule is eroded by the acids in the stomach
˙ inject able (micro spheres)
˙ biodegradable (need not be removed surgically)
˙ difficult to stop once injected
˙ pendent chain
△ drug is covalently bound to the polymer and is released by
bond scission owing to water or enzymes
△ the active agent is dissolved or dispersed within a polymeric matrix and
is not able to diffuse through that matrix.
˙ complex control
˙ generally more bulky devices and require implantation
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Microvasc. Res. 1996, 51:327-346
Pharmacol. Ther. 1994, 63(3):209–234
Journal of Controlled Release 2003, 91:173-181
J. Clin. Immunol. 1992, 12:391–405
Blood 1993, 82:2224–34
Ann. Rev. Immunol.
Total sales: around 5000億美金
資料來源:Front Line Strategic Consulting, Inc.
Catapres-TTS® (clonidine), Duragesic® (fentanyl), Estraderm® (estradiol), NicoDerm® (nicotine), Transderm-Nitro® (nitroglycerin)
* Particles with mass densities less than 0.4g/cubic centimeter and mean diameters exceeding 5 micrometers were inspired deep into the lungs and escaped the lungs’ natural clearance mechanisms until the inhaled particles delivered their therapeutic payload
David A. Edwards,* Justin Hanes,….,SCIENCE.VOL.276.20.JUNE.1997