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BioPharma’s NanoSorb delivery technology will put your products ahead of the times”! PowerPoint Presentation
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BioPharma’s NanoSorb delivery technology will put your products ahead of the times”! - PowerPoint PPT Presentation


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BioPharma’s NanoSorb delivery technology will put your products ahead of the times”! Small Unilamellar Vesicle (SUV) Large Unilamellar Vesicle (LUV) Multilamellar Unilamellar Vesicle (MLV) What is a Liposome ? Typical Size Ranges: SLV: 20-50 nm – MVL:100-1000 nm

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Presentation Transcript
slide3

Small

Unilamellar

Vesicle

(SUV)

Large

Unilamellar

Vesicle

(LUV)

Multilamellar

Unilamellar

Vesicle

(MLV)

What is a Liposome ?

Typical Size Ranges: SLV: 20-50 nm – MVL:100-1000 nm

oral liposomes rationale
Oral Liposomes Rationale

Liposomes can carry a wide variety of agents

Liposomes protect the gents they carry from

degradation by metabolic processes

Liposomes starting material (phospholipids,

other non-polar lipids) can assist in solubility

Liposomes can enhance absorption

cross section of a liposome

H2O Layer

Lipid Layer

Cross-Section of a Liposome

Polar Lipids (Phospholipid)

Lipid

Soluble ingredients

(Drugs, Nutrients &

vitamins)

Water

Soluble ingredients

(Drugs, Nutrients &

vitamins)

liposomes historical review

Liposomes: Historical Review

The First 10 Years

Discovered 35 years ago (1961)

Biological and chemical properties explored

The Middle Years (1975 to 1990)

Liposome physical characterization

Discovery of several types of liposomes

Techniques for liposome sizing

Pharmaceutical and pharmacological rationale that justify use of liposomes

Safety testing

liposomes historical review cont

Liposomes: Historical Review (cont.)

Recent Developments (1991 to present)

Scaling up and production of topical preparations

Stability issues overcome

First clinical trials

Commercialization of liposome products

The Future

Continued R&D, new applications

More sophisticated liposome products

Oral Delivery Systems

major modes of liposomal action and related applications
Major Modes of Liposomal Actionand Related Applications

Mode of Action

Application

  • Intracellular uptake :
  • lysosomes
  • endosomes
  • cytoplasm

Microbial diseases

Metal storage diseases

Gene manipulation

Specific Cancer Cell Targeting

Vaccines [efficient antigen presentation]

Slow release of drugs near

the target area

Tumors near fixed macrophages

Avoidance of tissue sensitive to drugs

Cardiotoxicity of doxorubicin

Circulating reservoirs

Blood surrogates

Enhanced absorption

and bioavailability!

Delivery to skin, lungs, eyes, mucosal tissues, GI tract

liposomal delivery
Liposomal Delivery

PROS

Enhanced Solubility

Sustained Release

Specific targeting – “Magic Bullet”

CHALLENGES

Stability, Sterility,

Retention (leaks)

WHY LIPOSOMES?

Biocompatible

Non-immunogenic

Biodegradable

Non-toxic

oral liposome stability
Oral Liposome Stability

Major Obstacles

  • Stomach pH
  • Bile Salts
  • Enzymes-Lipases
  • Clinically useful liposomes
  • must be stabile in vitro and in vivo
oral liposomes advantages
Oral Liposomes Advantages

Direct

Drug or nutrient stability and protection

Enhanced absorption of hydrophobic molecules

Enhanced absorption of encapsulated ingredients

Protein and Polypeptide protection

Decreased irritation to stomach lining from surface active drugs

Sublingual: direct absorption (bypass liver metabolism)

oral liposomes advantages16
Oral Liposomes Advantages

Indirect

Beneficial effects of Lecithin

Synthesis of neuro transmitters

Manufacturing of sterol hormones

Important role in fat transport in and out of cells

Can lower LDL and VLDL

slide17

New NanoSorbTM: BioPharma’s

Spontaneous Liposome Technology!

  • Patented NanoSorb LiposomesTM
    • Form and encapsulate spontaneously with water
    • Eliminate degradation, denaturization
    • Eliminate stability, retention and storage problems
    • Reduce production costs up to 90%!
fat content of human milk
Fat Content of Human Milk

4% Total Fat Content

Major Fat Components

Triacylglycerols 98%

Phosphosphlipids 1-2%

The colloidal structure of milk is still not

fully understood though clearly glycerols are

favored over phospholipids.

NanoSorb Molecule has similar components!

slide22

NanoSorbTM Liposome Applications

Functional Food &

Capsule Nutrition Delivery

Topical Transdermal Delivery

Sublingual Delivery

Long Circulating Liposomes for Systemic Delivery

via multilaminar liposomes

slide24
Nanosorb nanotechnology is unique in that it forms nanosized liposomes that encapsulate spontaneously upon the addition of water, without standard heating, cooling and agitation methods used for ordinary liposomes! Our new patented technology is therefore much more economical, while providing minimal potential for degradation, especially with highly sensitive bio-active nutraceuticals.

Uniqueness of the NanoSorb Molecule

slide25

Gentle Encapsulation With NanoSorb

Encapsulation with NanoSorb demonstrating no diminution of antioxidant activity

slide26

NanoSorb Liposomes Encapsulate More Effectively

The NanoSorb molecule also encapsulates ingredients more effectively than “old tech” liposomes, as the chart below demonstrates:

Comparative encapsulation % profile of CoQ10 for 3 months at room temperature

slide27

NanoSorb Bioavailabilty is Greater

CoQ-10 nano-encapsulated with NanoSorb liposomal tech is also more bioavailable than standard liposomal CoQ-10

slide28

“NanoSorbTM in Gel Capsules”

+

LipoCeuticals

Soft Gel

= NanoCaps

nanosorb gel cap applications
NanoSorb Gel Cap Applications
  • Pharmaceuticals
  • Nutraceuticals
  • OTC
advantages of nanosorb gel caps

Convenient lower dosage form

Initial protection from stomach environs

Liquid dosage form

Pre-dissolution of dry substance

Faster onset potential

Greater bioavailability

Advantages of NanoSorb Gel Caps
nanosorb gelcap benefits
NanoSorb Gelcap Benefits
  • Enhanced Absorption and Bioavailability of medicines, nutraceuticals, vitamins, proteins, peptides
  • Increased Effectiveness at existing dose
  • Sustained Release of ingredients
  • Protection of acid labile drugs/nutraceuticals
topical penetration study penetration efficacy
The NanoSorb delivery system also delivers a greater amount of the active ingredients through the skin as compared to conventional vehicles. Improved Dermal Penetration

Comparative study showing the amount of caffeine that penetrates through the layers of skin at eight hours.

Topical Penetration Study: Penetration = Efficacy
slide36

Transmucosal Delivery

NanoSorb Spray

Traditional

Spray

  • Penetration
  • is greater
  • Better
  • penetration allows for decreased dose in some cases
  • Greater
  • concentration in submucosal tissue
  • Higher
  • concentration in bloodstream

Mucosa

Submucosal Tissue

Connective Tissue

Bloodstream

nanosorb sublingual spray
NanoSorb Sublingual Spray®

The therapeutic effect of a nutrient

is directly related to the

quantity and rate

at which the unchanged nutrient

reaches the bloodstream

slide41

NanoSorbTM “Lipo-Ceuticals”

The most effective form of

nutraceutical, cosmeceutical and pharmaceutical delivery

to maintain product competitiveness!