1 / 17

Liu Baochi Shanghai Public Health Clinical Center affiliated to Fudan University

Treating patients with liver cirrhosis by BMT. Liu Baochi Shanghai Public Health Clinical Center affiliated to Fudan University. BACKGROUND. Decompensated liver cirrhosis is difficult to cure liver cirrhosis with AIDS is more difficult to give effective treatment

ivory-wilkinson
Download Presentation

Liu Baochi Shanghai Public Health Clinical Center affiliated to Fudan University

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript

  1. Treating patients with • liver cirrhosis by BMT Liu Baochi Shanghai Public Health Clinical Center affiliated to Fudan University

  2. BACKGROUND Decompensated liver cirrhosis is difficult to cure liver cirrhosis with AIDS is more difficult to give effective treatment Stem cell treatment bring the hope for the patients of AIDS with decompensated liver cirrhosis.

  3. Patients 7 AIDS patients with decompensated liver cirrhosis and portal ven hypertention , ascites, internal blooding were investigated.

  4. Methods Splenectomy were performed in 7 AIDS patients with liver cirrhosis to alleviate portal vein hypertention and avoid internal blooding.

  5. During the surgical procedure, a catheter was placed in the superior mesenteric vein in preparation for bone marrow transfusion (BMT).

  6. Methods 20mL bone marrow was aspirated by puncture of the iliac crest one week after surgery and transfused through the attached catheter into the portal vein.

  7. Methods One or two doses of BMT were performed on each patient at a one month interval.

  8. Results Except diminishment of ascites and recovery of serum albumin levels, total white blood cells and platelet count was also significantly improved. Unexpectedly, one month after BMT, CD4+ T cell count in peripheral blood of all 7 patients began to increase significantly.

  9. changes of CD4+ T lymph cell ( /ul) changes of CD8+ T lymph cell ( /ul)

  10. changes of albumin（g/L） changes of Tbl（umol/L）

  11. changes of WBC（×109/L） changes of Plate（×109/L）

  12. changes of Hb（g/L） changes of PT(秒)

  13. liver cirrhosis and highly enlarged spleen with huge amout of ascites before operation four months after operation and BMT. Ascites disappeared and liver enlarged

  14. Clinical significance of BMT It may change the standard of liver transplantation

  15. Conclusion BMT for the AIDS patient with liver cirrhosis can promote liver function and immune reconstruction.

  16. Thanks

More Related