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OPL

K +. K +. K +. K +. K +. K +. K +. K +. light. Ca 2+. Ca 2+. Ca 2+. Ca 2+. Ca 2+. Ca 2+. Glu. SUPPLEMENTAL FIGURE 1. Distribution of N- glycoslylated proteins and the changes in the outer plexiform layer (OPL) in response to light. OPL. On- bipolar cell

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OPL

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  1. K+ K+ K+ K+ K+ K+ K+ K+ light Ca2+ Ca2+ Ca2+ Ca2+ Ca2+ Ca2+ Glu SUPPLEMENTAL FIGURE 1. Distribution of N-glycoslylated proteins and the changes in the outer plexiform layer (OPL) in response to light. OPL On- bipolar cell hyperpolarised in dark * NCKX * * Cav1.4 * mGluR6 Adenylyl Cyclase Type 1 K+ 4 Na+ Glu PKA activation GPI Photoreceptor depolarised in dark Ca2+ * cAMP pathway various on channels β Glu ATP some PK13 isoforms  Nyctalopin ATP Glu Gαo Glu GPI Glu TRMP1 Inwardly rectifying K+ channels (GIRK) voltage gated Ca2+ channels potassium pump glutamate released in dark Na+ OPL On- bipolar cell depolarised in light * NCKX * * * Adenylyl Cyclase Type 1 Cav1.4 mGluR6 K+ 4 Na+ PKA activation cAMP pathway various ion channels Photoreceptor hyperpolarised Ca2+ * PKC activation ↑iCa2+ Nyctalopin Calmodulin activation Phosphatidylinositol pathway activation GPI TRMP1 + PLC CAMK pathway activation IP3 PIP2 helps open Ca2+ channels potassium pump b-wave a-wave Na+ Gαo β  β GDP Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu K+ K+ K+ K+

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