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Comparative Analysis of PDE Enzymes from Trypanosoma cruzi and Human PDE4B

This figure displays a sequence alignment between Trypanosoma cruzi PDEC and human PDE4B. Identical residues are marked in red boxes with white characters, while similar residues are displayed in red characters. The secondary structures are indicated as squiggles. The figure also includes an overlay of human PDE4B crystal structure and Trypanosoma cruzi PDEC homology model, along with the docking conformations of compounds around the active site of PDEC.

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Comparative Analysis of PDE Enzymes from Trypanosoma cruzi and Human PDE4B

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  1. Figure S1. Sequence alignment between Trypanosoma cruzi PDEC (UniProtKB/TrEMBLaccession number Q53I60_TRYCR) and human PDE4B, PDB entry 1XMY). Identical residues are in red boxes and white characters, similar residues are in red characters. Alpha helices are displayed as squiggles.

  2. A B Figure S2. A.The overlay of human PDE4B crystal structure (green ribbons) and Trypanosoma cruzi PDEC homology model (purple ribbons). B. The docking conformations of identified compounds around the active site of PDEC.

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