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Introduction in toxicology. Determination of toxicity. Dose-response curve. Mode of entry of toxins. PowerPoint Presentation
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Introduction in toxicology. Determination of toxicity. Dose-response curve. Mode of entry of toxins. - PowerPoint PPT Presentation


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Lecture 1. Introduction in toxicology. Determination of toxicity. Dose-response curve. Mode of entry of toxins. Clinical Toxicology -20 to 50 compounds tested Many routine kits available Automation possible. Analytical Toxicology 8000 pharmaceuticals are currently used

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Presentation Transcript
slide1

Lecture 1

Introduction in toxicology.

Determination of toxicity.

Dose-response curve.

Mode of entry of toxins.

slide2

Clinical Toxicology

  • -20 to 50 compounds tested
  • Many routine kits available
  • Automation possible
  • Analytical Toxicology
  • 8000 pharmaceuticals are currently used
  • 40000 other potentially toxic compounds exist
  • routine kits available for screening for some common drugs
  • no automation
slide3

Types of Intoxication:

Known origin Unknown origin

Causes of intoxication %%

Ethanol 32

Benzodiazepines 60

Tricyclic antidepessants 13

Barbiturates 6

Acetaminophen 1

Salicylates 2

slide5

Analytical techniques used in emergency toxicology

Spot tests

Immunoassays

Gas chromatography

GC-MS

HPLC and LC-MS

Thin layer chromatography

slide6

Dose-response curve

What is there that is not poison?

All things are poison and nothing

without poison

Solely the dose determines that

a thing is not a poison

slide10

Non-linear response curves

+

effective drug

food

nonactive

0

log C

toxic

dangerous drug

-

Highly toxic

slide11

Mode of entry of toxins

Skin transport

Respiratory route

Oral route

slide12

log C

log C

One-compartment kinetics Two-compartment kinetics

time

time

slide13

Cocaine metabolic profile. BE-benzoyllecgonine,

EME-ecgonine methyl ester,CE- cocethylene