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Disclosures. Investigator initiated research funding:Hoffman LaRoche, GlaxoSmithKline, Sanofi-PasteurAdvisory BoardsNovartis, GlaxoSmithKline, Sanofi-Pasteur, Pfizer, Hoffman-LarocheHonoraria for lecturesGlaxoSmithKline, Hoffman-Laroche, Gilead Biosciences . G Neumann et al. Nature 459, 931-939 (2009) doi:10.1038/nature08157.

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