chapter 15 neural integration i sensory pathways and the somatic nervous system l.
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Chapter 15: Neural Integration I: Sensory Pathways and the Somatic Nervous System. Neural Integration. Afferent Division of the Nervous System. Receptors Sensory neurons Sensory pathways. Afferent Division. Sensory receptors  sensory pathway  Somatic Sensory info

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afferent division of the nervous system
Afferent Division of the Nervous System
  • Receptors
  • Sensory neurons
  • Sensory pathways
afferent division
Afferent Division
  • Sensory receptors  sensory pathway 
  • Somatic Sensory info
    • Sensory cortex of cerebrum
    • Cerebellum
  • Visceral Sensory info
    • Reflex centers in brainstem
    • Reflex centers in diencephalon
sensory receptors
Sensory Receptors
  • Specialized cells that monitor specific conditions in the body or external environment
  • General Senses:
    • Temp, pain, touch, pressure, vibration, proprioception
    • Simple receptors located anywhere on body
  • Special Senses:
    • Are located in sense organs such as the eye or ear
    • Olfaction, vision, gustation, hearing, equilibrium
    • Complex receptors located in specialized sense organs
sensory receptors6
Sensory Receptors
  • Sensation – the sense info; action potentials
    • Taste, hearing, equilibrium, and vision provided by specialized receptor cells
    • Communicate with sensory neurons across chemical synapses
  • Perception – conscious awareness of sensation
sensory receptors7
Sensory Receptors
  • Transduction – conversion of environmental stimulus into action potential by sensory receptor
    • Action potential:
      • When stimulated, a receptor passes information to the CNS in the form of action potentials along the axon of a sensory neuron
    • Receptors specific for particular type of stimulus
    • Specificity is due to structure of receptor
    • Simplest receptors are dendrites (free nerve endings), least specific
free nerve endings
Free Nerve Endings
  • Branching tips of dendrites
  • Not protected by accessory structures
  • Can be stimulated by many different stimuli
sensory receptors9
Sensory Receptors
  • Receptive field
    • area monitored by single receptor (e.g. touch: arm vs. fingertip)
    • Area is monitored by a single receptor cell
    • The larger the receptive field, the more difficult it is to localize a stimulus
sensory receptors10
Sensory Receptors
  • Labeled line
    • Link between receptor and processing site in CNS
      • Stimulation anywhere on labeled line will produce the same perception (e.g. phantom limb)
  • Stimulus -> receptor -> transduction -> action potential -> sensation ->-> CNS perception
sensory pathways
Sensory Pathways
  • Deliver somatic and visceral sensory information to their final destinations inside the CNS using:
    • nerves
    • nuclei
    • tracts
sensory receptors12
Sensory Receptors
  • Tonic Receptors:
    • Always active
    • Signal at different rate when stimulated
    • Monitor background levels
  • Phasic Receptors:
    • Activated by stimulus
    • Become active for a short time whenever a change occurs
    • Monitor intensity and rate of change of stimulus
sensory receptors13
Sensory Receptors
  • Adaptation
    • Reduced sensitivity to a constant stimulus
    • Peripheral Adaptation:
      • Reduction in receptor activity
      • Phasic fast adapting
      • Tonic  slow or non adapting
        • Remind you of an injury long after the initial damage has occurred
    • Central Adaptation:
      • Inhibition of nuclei along labeled line
  • Not all pathways will adapt
four types of general sensory receptors
Four types of General Sensory Receptors
  • Pain: nociceptor
  • Temperature: thermoreceptor
  • Physical: mechanoreceptor
  • Chemicals: chemoreceptors
  • All can be found in both somatic (exteroceptors) and visceral (interoceptors) locations except:
    • Proprioceptors (a mechanoreceptor) are somatic only
      • report the positions of skeletal muscles and joints
1 pain receptors nociceptors
1. Pain Receptors: Nociceptors
  • Detect Pain
  • Are common in the:
    • superficial portions of the skin
    • joint capsules
    • within the periosteum of bones
    • around the walls of blood vessels
  • Rare in deep tissue and visceral organs
  • Consist of free nerve endings with large receptor fields

Figure 15–2

1 pain receptors nociceptors16
1. Pain Receptors: Nociceptors
  • Mode of Action:
    • Injured cells release arachidonic acid
    • Arachidonic acid is converted into prostaglandins by the interstitial enzyme cyclo-oxygenase
    • Prostaglandins activate nociceptors
      • Many pain medications like aspirin function to inhibit cyclo-oxygenase
1 pain receptors nociceptors17
1. Pain Receptors: Nociceptors
  • Once transduced pain sensations are carried on either type A and type C fibers/axons:
    • Type A:
      • Fast pain; stab or cut; triggers defensive reflexes
    • Type C:
      • Slow pain; aching pain
  • Tonic receptors with no peripheral adaptation
  • Pain levels are modulated by endorphins which inhibit CNS function
2 thermoreceptors
2. Thermoreceptors
  • Detect temperature
  • Found in skin, skeletal muscle, liver, and hypothalamus
  • Consist of free nerve endings
  • Phasic receptors that adapt easily
3 mechanoreceptors
3. Mechanoreceptors

**Detect membrane distortion

Three receptor types:

  • Tactile Receptors
  • Proprioceptors
  • Baroreceptors
3 mechanoreceptors20
3. Mechanoreceptors
  • Tactile Receptors
    • Detect touch, pressure and vibration on skin
    • Free nerve endings
      • Detect touch on skin
      • Tonic receptors with small receptor fields
    • Root hair plexus nerve endings
      • Detect hair movement
      • Phasic receptors, adapt rapidly
    • Tactile discs/Merkel’s discs
      • Detect fine touch
      • Extremely sensitive
      • Whole cell tonic receptors
3 mechanoreceptors21
3. Mechanoreceptors
  • Tactile Receptors
    • Tactile corpuscles/Meissner’s corpuscles
      • Detect fine touch and vibration
      • Larger receptor structure
      • Phasic receptors, adapt rapidly
    • Lamellated corpuscles/Pacinian corpuscles
      • Detect deep pressure
      • Larger multi-layer receptors
      • Phasic receptor, adapt rapidly
    • Ruffini corpuscles
      • Detect pressure and distortion
      • Large tonic receptors, no adaptation
3 mechanoreceptors23
3. Mechanoreceptors
  • Proprioceptors:
    • Detect positions of joints and muscles
    • Tonic receptors, do not adapt, complex
    • Muscle spindles
      • Modified skeletal muscle cell
      • Monitor skeletal muscle length
    • Golgi tendon organs
      • Dendrites around collagen fibers at the muscle-tendon junction
      • Monitor skeletal muscle tension
    • Joint capsule receptors

- Monitor pressure, tension and movement in the joint

3 mechanoreceptors25
3. Mechanoreceptors
  • Baroreceptors
    • Detect pressure changes
    • Found in elastic tissue of blood vessels and organs of digestive, reproductive and urinary tracts
    • Consists of free nerve endings
    • Phasic receptors, adapt rapidly
4 chemoreceptors
4. Chemoreceptors
  • Detect change in concentration of specific chemicals or compounds
    • E.g. pH, CO2
  • Found in respiratory centers of the brain and in large arteries
  • Phasic receptors, adapt rapidly
key concept
KEY CONCEPT
  • Stimulation of a receptor produces action potentials along the axon of a sensory neuron
  • The frequency and pattern of action potentials contains information about the strength, duration, and variation of the stimulus
  • Your perception of the nature of that stimulus depends on the path it takes inside the CNS
somatic sensory pathways
Somatic Sensory Pathways
  • Carry sensory information from the skin and musculature of the body wall, head, neck, and limbs
somatic sensory pathways31
Somatic Sensory Pathways
  • Consist of two or three neurons:
  • First Order Neuron:
    • Sensory neuron
    • Connects from receptor to CNS
    • Cell body is in dorsal root ganglion/cranial nerve ganglion
  • Second Order Neuron:
    • Interneuron (stimulated by first order)
    • Located in spinal cord or brain stem
    • Subconscious processing of info
  • Third Order Neuron:
    • Located in thalamus
    • Relays info to primary somatosensory cortex of cerebrum for conscious awareness (perception)
slide32
Only ~1% of somatic sensory info reaches cerebrum (major changes only, “background” in filtered)
    • LSD interferes with sensory damping/filtering = sensory overload
  • All sensory info undergoes decussation in spine before reaching target in CNS
posterior column pathway
Posterior Column Pathway
  • Carries sensations of highly localized (“fine”) touch, pressure, vibration, and proprioception

Figure 15–5a

visceral sensory pathways
Visceral Sensory Pathways
  • Interoceptors transmit info to solitary nucleus of medulla oblongata for relay to visceral centers in brainstem and diencephalon
    • No perception
  • Two neurons: 1st and 2nd order
efferent division
Efferent Division
  • Conscious and subconscious motor centers in brain -> motor pathways ->
    • Somatic Nervous System  skeletal muscle
    • Autonomic Nervous System  visceral effectors

- Smooth and cardiac muscle, glands, and adipose

somatic nervous system
Somatic Nervous System
  • Motor control of skeletal muscle
  • Consists of two neurons:
    • Upper motor neuron
      • Has soma in CNS processing center:
      • Primary motor cortex of cerebrum

- voluntary control

      • Cerebrum, diencephalon, and brain stem

- subconscious control:reflex

      • Basal nuclei of cerebrum and cerebellum

- coordination, balance, fine tuning

    • Lower motor neuron
      • Soma in brain stem or spinal cord
      • Links to skeletal muscle motor unit
processing in the thalamus
Processing in the Thalamus
  • Determines whether you perceive a given sensation as fine touch, as pressure, or as vibration
motor related disorder
Motor Related Disorder
  • Parkinson’s Disease
    • Jittery movements: lack of fine tuning of motor
    • Results from degeneration of dopamine neurons of substantia nigra
      • Inhibits basal nuclei
    • Overactive basal nuclei = “ticks”
  • Amylotrophic Lateral Sclerosis
    • Degeneration of motor neurons in CNS
    • Causes muscle atrophy and death
motor related disorder42
Motor Related Disorder

3. Epilepsy

  • 1/25 people
  • Wide range in condition:
    • Absence seizures (blank) to grand mal seizures (convulsions, unconscious)
  • Uncontrolled/chaotic neuron activity in brain: blocks normal messages
slide43

When the nociceptors in your hand are stimulated, what sensation do you perceive?

  • pain
  • heat
  • vibration
  • pressure
slide44

What would happen to you if the information from proprioceptors in your legs were blocked from reaching the CNS?

  • no pain sensations from the legs
  • uncontrolled blood pressure in the legs
  • uncoordinated movements and inability to walk
  • no tactile sensations in the legs
autonomic nervous system ans
Autonomic Nervous System(ANS)
  • Operates without conscious instruction
  • Coordinates systems functions:
    • cardiovascular
    • respiratory
    • digestive
    • urinary
    • reproductive
autonomic nervous system
Autonomic Nervous System
  • Motor control of visceral effectors
  • Involves three neurons:
    • Visceral motor nuclei in hypothalamus to autonomic nuclei in CNS
    • Autonomic nuclei to autonomic ganglia in PNS
    • Autonomic ganglia to visceral effector

**Nuclei = in CNS, a center with a visible boundary

**Ganglia = in PNS, collection of somas together in one place

slide50
Two subdivisions
  • Sympathetic: “fight or flight”
  • Parasympathetic: “rest and digest”
  • Typically oppose each other on same effector
  • Some effectors innervated by only one:
    • Blood vessels/sweat glands –> sympathetic only
    • Smooth muscle of eye –> parasympathetic only
sympathetic division
Sympathetic Division
  • Prepares body for heightened somatic activity
  • Ganglia:
    • Located near spinal cord
    • Adrenal Medulla
      • Center of adrenal gland (above kidney)
      • Releases epinephrine and norepinephrine as hormones into blood to control effectors body wide at one (endocrine function)
sympathetic division52
Sympathetic Division
  • Sympathetic Activation Results
    • Increased alertness
    • Insensitivity to pain
    • Elevation in blood pressure, respiratory rate
    • Elevation in muscle tone
    • Mobilization of energy reserves
sympathetic division neurotransmitter
Sympathetic Division: Neurotransmitter
  • Preganglionic Neurons release acetycholine

(cholinergic synapse)  EPSP on ganglionic neuron

- directly open ion channel

- fast acting, short lived

sympathetic division neurotransmitter54
Sympathetic Division: Neurotransmitter
  • Ganglionic neurons/postganglionic fibers release norepinephine at effectors (adrenergic synapse)
    • NE and E from adrenal medulla: hormones
    • Result depends on type of receptor:
      • Alpha1 and beta1 receptors:

- excititory/stimulatory to effector

      • Alpha2 and beta2 receptors:
        • Inhibitory

**beta-blockers: block beta1 receptors

    • G protein  second messengers
    • Slow acting but long lasting
parasympathetic division
Parasympathetic Division
  • Stimulates visceral activity
  • Maintains homeostasis
  • Ganglia located in or near effector
  • Vagus nerve carries 75% of parasympathetic innervations
parasympathetic division56
Parasympathetic Division
  • Parasympathetic activations results:
    • Constriction of pupils
    • Secretion by digestive glands
    • Secretion of hormones for nutrient uptake
    • Sexual arousal
    • Activation of digestive tract
    • Defecation and urination
    • Constriction of respiratory pathways
    • Reduction in heart rate
parasympathetic division neurotransmitters
Parasympathetic Division:Neurotransmitters
  • All release Ach: all cholinergic synapses
  • Effects quick, localized, short-lived
  • Type of effect depends on receptor:
    • Nicotonic receptor

- Excititory effect on target

    • Muscarinic receptor

- Inhibitory or excititory, depends on target cell

slide58

How many motor neurons are required to conduct an action potential from the spinal cord to smooth muscles in the wall of the intestine?

  • one
  • two
  • four
  • six
slide59

While out for a brisk walk, Julie is suddenly confronted by an angry dog. Which division of the autonomic nervous system is responsible for the physiological changes that occur in Julie as she turns and runs?

  • parasympathetic division
  • somatic nervous system
  • enteric nervous system
  • sympathetic division
slide60

On the basis of anatomy, how could you distinguish the sympathetic division from the parasympathetic division of the autonomic nervous system?

  • origin of preganglionic fibers
  • number of preganglionic fibers
  • placement of ganglia
  • both 1 and 3 are correct
slide61

How would a drug that stimulates acetylcholine receptors affect the sympathetic nervous system?

  • complete shut-down of sympathetic activity
  • decreased sympathetic activity
  • uncontrolled sympathetic activity
  • increased sympathetic activity
slide62

An individual with high blood pressure is given a medication that blocks beta receptors. How could this medication help correct that person’s condition?

  • aids sympathetic stimulation
  • decreases blood volume
  • prevents sympathetic stimulation
  • none of the above
slide63

Which nerve is responsible for the parasympathetic innervation of the lungs, heart, stomach, liver, pancreas, and parts of the small and large intestines?

  • cranial nerve IX
  • splanchic nerve
  • vagus nerve
  • pelvic nerve
slide64

What effect would the loss of sympathetic tone have on blood flow to a tissue?

  • Blood flow would decrease.
  • Blood flow would be redirected to heart, lungs and brain.
  • Blood flow would increase.
  • Blood flow would become erratic.
slide65

What physiological changes would you expect in a patient who is about to undergo a root canal and is quite anxious about the procedure?

  • change in motility of digestive tract
  • increased heart rate
  • increased breathing rate
  • all of the above
slide66

Harry has a brain tumor that is interfering with the function of his hypothalamus. Would you expect this tumor to interfere with autonomic function? Why or why not?

  • Yes; hypothalamus regulates ANS.
  • Yes; all brain tumors affect ANS functioning.
  • No; ANS has no connection to the hypothalamus.
  • No; ANS function is regulated by thalamus.
higher order functions
Higher Order Functions
  • Involve cerebral cortex
  • Involve both conscious and subconscious processing
  • Are not part of genetic wiring (reflex): can be modified

e.g. memory and consciousness

memory
Memory
  • Memory – storage and retrieval of info
  • Fact memories – specific bits of info
  • Skill memories – learned motor behaviors
  • Short term memory (STM)
    • primary/working memory
    • Rapid recall but short retention
    • Store 7-8 bits of info at one time
    • STM can be converted to long term memory for more permanent storage
memory69
Memory
  • Memory consolidation: STMLTM
    • Performed by hippocampus
    • Depends on:
      • Emotional State
      • Rehearsal
      • Association
      • Automatic memory
memory70
Memory
  • Long term memory (LTM)
    • Infinite info
    • Can be stored for lifetime
    • Secondary memories:
      • fade with time, can be difficult to recall much later
    • Tertiary memories:
      • part of one’s consciousness (e.g. name)
    • LTMs are broken into component parts to store in appropriate cerebral cortex
      • E.g. visual, olfactory, etc.
memory71
Memory
  • Mechanism of memory storage not clearly understood but involves:
  • New mRNA and protein synthesis in neurons involved
  • Change of shape of dendritic spines
  • Change in size and number of synaptic terminals
  • Release of more neurotransmitter
memory72
Memory
  • Amnesia = loss of memory, due to disease or trama of hippocampus and amygdala
  • Retrograde Amnesia:
    • Lose memories of past events,
    • Remember now  forward
  • Anterograde Amnesia
    • Unable to store new memories
    • Only remember past
consciousness
Consciousness
  • Conscious: aware of external stimuli
  • Unconscious: range of unawareness
    • Drowsy  coma  brain dead
sleep
Sleep
  • Sleep = partial unconsciousness from which a person can be aroused with stimuli
  • Deep Sleep
    • Relaxed state
    • Heart and respiratory rate decreased
    • Minimal activity in cerebral cortex
  • REM (rapid eye movement): sleep
    • active, dreaming state
    • Cerebral cortex as active/more active than in conscious state
    • But little reaction to outside stimuli
    • Skeletal muscles inhibited
slide76
Alternate between deep and REM sleep throughout sleep period
  • Sleep required for life, but not clear why
  • Lack of sleep leads to serious disturbance in mental function
  • During sleep protein synthesis in neurons increases: sleep may be used to repair and recharge neural tissue
sleep disorders
Sleep Disorders
  • Narcolepsy
    • Condition where person lapses abruptly into sleep for ~ 15 min
    • Usually follows pleasant event
    • Cause unknown
    • Sufferers show reduced levels of REM sleep at night
  • Sleep apnea
    • Person stops breathing until hypoxia (lack of O2) wakes them
    • Hypoxic wake response ability declines with age or respiratory illness
arousal
Arousal
  • Requires Reticular Activating System (RAS)
  • RAS located in brainstem, provides consciousness
  • Mechanism:
    • Stimulation of RAS  activation of cerebral cortex
    • Positive feedback (reverberation) on RAS maintains consciousness after initial stimulus
    • Over time RAS becomes less responsive = sleep feeling
  • Internal clock in suprashiasmatic nucleus of hypothalamus
    • sets normal sleep-wake cycle
slide79

Which of the following is not a characteristic of higher order functions?

  • require cerebral cortex
  • involve conscious and unconscious processing
  • part of the programmed wiring of the brain
  • subject to modification over time
slide80

After suffering a head injury in an automobile accident, David has difficulty comprehending what he hears or reads. This symptom might indicate damage to which portion of his brain?

  • right temporal lobe of the cerebrum
  • left temporal lobe of the cerebrum
  • frontal lobe of the cerebrum
  • left parietal lobe of the cerebrum
slide81

As you recall facts while you take your A&P test, which type of memory are you using?

  • long term memory
  • skill memory
  • memory consolidation
  • short term memory
slide82

You are asleep. What would happen to you if your reticular activating system were suddenly stimulated?

  • You would wake up.
  • You would experience a pleasantdream.
  • You would experience a nightmare.
  • You would experience muscular contraction and cramping.
age related changes
Age Related Changes
  • Decrease
    • Brain size and weight (cerebrum)
    • Number of neurons
    • Blood flow to brain (incr. chance of stroke)
    • Number of synapses
    • Neurotransmitter production
age related changes84
Age Related Changes
  • Accumulation of deposits:
    • Inside Cells
      • lipofuscin: granular pigment
      • Neurofibrillary tangles: packed neurofibrils
    • Extracellular
      • plaques: collections of fibrillar proteins entangling abnormal cell processes
        • Amyloid proteins: normal proteins misfolding become sticky

* All forms of deposits affect processing and memory ability, motor speed, and sensory sensitivity

age related changes85
Age Related Changes
  • Increased disease:
  • Alzheimer’s Disease
    • Loss of higher order functions
    • Occurs in 15% over 65 years
    • Progressive, untreatable
    • Due to reduction of Ach levels and accumulation of beta amyloid peptide
      • Plaques and tangles
    • Current treatments block Ach breakdown
age related changes86
Age Related Changes

2. Huntington’s Disease

  • genetic, middle age onset
  • Accumulation of huntington’s protein kills neurons of basal ganglia and cerebral cortex  ticks, cognitive dysfunction
  • Progressive and fatal
    • On set  death in ~ 15 years
slide87

One of the problems associated with aging is difficulty in recalling things or even a total loss of memory. What are some possible reasons for these changes?

  • decreased blood flow to brain
  • formation of neurofibrillary tangles
  • reduction in brain weight
  • all ofthe above
summary
SUMMARY
  • Brain, spinal cord, and peripheral nerves continuously communicate with each other and with internal and external environments
  • Information arrives via sensory receptors and ascends within afferent division, while motor commands descend and are distributed by efferent division
  • Sensory receptor is a specialized cell or cell process that monitors specific conditions within body or in external environment:
    • arriving information is called a sensation
    • awareness of a sensation is a perception
summary90
SUMMARY
  • General senses are pain, temperature, physical distortion, and chemical detection:
    • receptors for these senses are distributed throughout the body
  • Special senses, located in specific sense organs, are structurally more complex
  • Each receptor cell monitors a specific receptive field
  • Transduction begins when a large enough stimulus changes the receptor potential reaching generator potential
summary91
SUMMARY
  • Tonic receptors are always active
  • Phasic receptors provide information about intensity and rate of change of a stimulus
  • Adaptation is a reduction in sensitivity in presence of a constant stimulus
  • Tonic receptors are slow-adapting receptors, while phasic receptors are fast-adapting receptors
  • 3 types of nociceptor found in the body provide information on extremes of pain:
    • temperature
    • mechanical damage
    • dissolved chemicals
      • myelinated Type A fibers carry fast pain
      • Type C fibers carry slow pain
summary92
SUMMARY
  • Thermoreceptors are found in the dermis
  • Mechanoreceptors are sensitive to distortion of their membranes and include:
    • tactile receptors, baroreceptors, proprioceptors
      • 6 types of tactile receptors in the skin
      • 3 types of proprioceptors
  • Chemoreceptors include carotid bodies and aortic bodies
  • Sensory neurons that deliver sensations to CNS are referred to as first-order neurons:
    • synapse on second-order neurons in brain stem or spinal cord
    • next neuron in this chain is a third-order neuron, found in the thalamus
summary93
SUMMARY
  • Functions of the autonomic nervous system (ANS)
  • Functions of CNS preganglionic neurons
  • The sympathetic division
  • Sympathetic activation
  • Function of neurotransmitters:
    • acetylcholine (ACh)
    • norepinephrine (NE)
    • epinephrine (E)
summary94
SUMMARY
  • Sympathetic ganglionic neurons
  • Two types of sympathetic receptors:
    • alpha receptors
    • beta receptors
  • The parasympathetic division (food processing and energy absorption)
  • Muscarinic and nicotinic receptors
summary95
SUMMARY
  • Memory:
    • short–term or long–term
  • Memory consolidation
  • Consciousness, unconsciousness, and sleep
  • Age-related changes in the nervous system