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Chapter 6: “Communication, Integration and Homeostasis

Chapter 6: “Communication, Integration and Homeostasis. Cell to cell communication Gap junctions Paracrines and autocrines Long distance communication Signaling pathways Receptors Ion channels Signal transduction. Cell to cell communication. connexins. Ca++ ATP.

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Chapter 6: “Communication, Integration and Homeostasis

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  1. Chapter 6: “Communication, Integration and Homeostasis • Cell to cell communication • Gap junctions • Paracrines and autocrines • Long distance communication • Signaling pathways • Receptors • Ion channels • Signal transduction

  2. Cell to cell communication connexins Ca++ ATP

  3. Cell to cell communication Diffuse to targets through interstitial fluid e.g. Histamine leaves damaged cell  capillary cell (endothelial cell) becomes more permeable  fluid accumulates around damaged cell swelling

  4. Examples of paracrine molecules: • Cytokines, peptides (e.g. erythropoietin) • Eicosanoids, lipid derived (e.g. prostaglandins, leukotrienes)

  5. Cell to cell communication: long distance through blood vessels

  6. Cell to cell communication: long distance through neurons Neurotransmitter molecules

  7. Cell to cell communication: long distance Neurons release product into blood e.g. oxytocin

  8. Signaling pathways in a cell. - receptor proteins

  9. Classes of membrane receptors e.g. Neuromuscular junction e.g. insulin e.g. Olfaction Vision Hormones Some neurotransmitters e.g. blood clotting -platelets

  10. How ion channels participate in cell to cell communication. e.g. Neural control of skeletal muscle contraction.

  11. The idea of signal transduction Can adjust volume

  12. Signal amplification, the idea

  13. ** Signal transduction in a cell.

  14. The idea that signal transduction is a cascade. E.g. blood clotting

  15. In receptor-enzymes, the amplifier enzyme is in the cell membrane.

  16. The G-protein coupled receptor adenylyl cylcase cascade.

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