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## PowerPoint Slideshow about 'Introduction' - isabelle-barrett

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Breast cancer is the MOST common cancer affecting women, & Long Island exemplifies this phenomenon

Breast cancer kills the MOST women out of ALL other cancer-related deaths

Over 80% of breast cancer tumors are activated by estrogen

Long Island consistently exhibits ABOVE EXPECTED rates of breast cancer

Long Island exhibits one of the highest breast cancer deaths

- Long Island has unique reserve of 4-Nonylphenol (4-NP) in its environment (Jacquez, 2001)
- Long Island (NY) covered by farms (since 17th century)

Environmental toxins are involved in the development of breast cancer

Estrogen increases breast cancer risk, causes birth defects + learning disabilities

Shown to interfere with hormonally-mediated pathways

OVER half of the reported cases of breast cancer cannot be explained by known risk factors

Therefore, external factors must contribute to increased breast cancer risk

Hypothesis

We hypothesize that 4-NP and estrogen will induce similar regulation of gene expression in U937 human immune cells, suggesting that 4-NP indeed mimics estrogen in the body, augmenting breast cancer risk.

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