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Natalie Garcia Anatomy&Physiology 4 th Period. Erythema Multiforme. History Of The Disease. First described in 1860 by Ferdinand von Hebra as a severe, self-limiting disorder that is characterized by red skin lesions that appear as papules.

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natalie garcia anatomy physiology 4 th period
Natalie Garcia

Anatomy&Physiology

4th Period

Erythema Multiforme

history of the disease
History Of The Disease
  • First described in 1860 by Ferdinand von Hebra as a severe, self-limiting disorder that is characterized by red skin lesions that appear as papules.
  • Later on in 1922 Johnson and Stevens discovered an even more severe type of Erythema Multiforme.
  • In 1950 erythema multiforme major and erythema multiforme minor were coined by Thomas to describe this skin aliment.
  • The first case of Erythema Multiforme is unknown.
symptoms anatomical aspects
Symptoms/Anatomical Aspects
  • The Disorder occurs on the skin because of an allergic reaction or infection.
  • Multiple skin lesions can start quickly and may return:
    • May spread
    • May appear as a nodule, papule, or macule and may look like hives
    • Central sore can be surrounded by pale red rings
    • May blisters of various sizes
    • Located on the upper body, legs, arms, palms, hands, or feet
    • May involve the face or lips
    • Usually even on both sides
symptoms physiological aspects
Symptoms/Physiological Aspects
  • What may be affected is the thin moist tissue lining the body's cavities (internal mucous membranes).
  • Other causes include viral infections (such as cold sores), bacterial infections, pregnancy, vaccination, or radiation therapy.
  • In Stevens-Johnson, the mucous membranes of the lips, mouth, eyes, nasal passages, and genitals can blister and bleed.
  • In toxic epidermal necrolysis, the mucous membrane bleeding is less severe.
treatment options and prognosis
Treatment Options And Prognosis
  • To begin treatment it involves preventing infection and treating the symptoms also to stop taking any suspecting medication with approval from a doctor.
  • Mild symptoms consists of taking medications such as antihistamines to control itching, moist compresses applied to the skin, oral antiviral medication if it is caused by herpes simplex, over-the-counter medications to reduce fever and discomfort, topical anesthetics (especially for mouth lesions) to ease discomfort.
  • Treatment for severe symptoms is to use antibiotics to control any skin infections, medication to control inflammation, hospitalization and treatment in an intensive care or burn care unit for severe cases such as Stevens-Johnson syndrome and toxic epidermal necrolysis.
  • Mild forms of erythema multiforme usually get better in 2 - 6 weeks, but they may return. More severe forms may be difficult to treat. Stevens-Johnson syndrome and toxic epidermal necrolysis have high death rates.
who is most commonly affected by this disorder
Who Is Most Commonly Affected By This Disorder?
  • Erythema Multiforme most commonly affects young adults.
  • But all age groups can be affected.
  • Erythema Multiforme occurs 2 to 3 times more in men than in women.
  • About 0.8 to 6% of all cases of this disorder occurs in the United States alone in every 1 million people.
  • The most common cause is the herpes simplex virus (the same virus that causes cold sores).
  • It can sometimes be because of drug reactions, cancer, radiation, other viruses, or bacteria.
  • Sometimes there may be no cause for it.
bibliography
Bibliography
  • "Erythema Multiforme: MedlinePlus Medical Encyclopedia." U.S National Library of Medicine. Ed. Linda J. Vorvick. U.S. National Library of Medicine, 23 Oct. 2012. Web. 23 Nov. 2012. <http://www.nlm.nih.gov/medlineplus/ency/article/000851.htm>.
  • "Health Guide." Erythema Multiforme. N.p., n.d. Web. 23 Nov. 2012. <http://health.nytimes.com/health/guides/disease/erythema-multiforme/overview.html>.
  • "Prime Health Channel." Prime Health Channel Erythema Multiforme Comments. N.p., n.d. Web. 23 Nov. 2012. <http://www.primehealthchannel.com/erythema-multiforme.html>.
  • Board, A.D.A.M. Editorial. "Erythema Multiforme." Erythema Multiforme. U.S. National Library of Medicine, 18 Nov. 2012. Web. 23 Nov. 2012. <http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0001854/>.
  • Oakley, Amanda. "DermNet NZ." Erythema Multiforme. Ed. Delwyn Dyall-Smith. N.p., 2009. Web. 23 Nov. 2012. <http://dermnetnz.org/reactions/erythema-multiforme.html>.
  • "Medical Journal And Resources Portal - MedConnect SEA." Medical Journal And Resources Portal - MedConnect SEA. N.p., 2005. Web. 23 Nov. 2012. <http://www.medconnect.com.sg/>.
  • "Erythema Multiforme." (Stevens-Johnson Disease). N.p., 28 May 2012. Web. 23 Nov. 2012. <http://www.nmihi.com/e/erythema-multiforme.htm>.