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Distinguishing Almost Identical Twin Molecules

Detecting single molecules with Surface Enhanced Raman Spectroscopy (SERS) is feasible but proving signals are from single molecules is challenging. Scientists at MRSEC differentiated crystal violet molecules with isotopic variations. Computational methods confirmed presence of specific isotopes in experiments.

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Distinguishing Almost Identical Twin Molecules

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  1. Distinguishing almost identical twin molecules Monica Olvera, Northwestern University, DMR 1121262 Detecting single molecules is now possible for certain molecules using Surface Enhanced Raman Spectroscopy (SERS), but proving that a signal is due to a single molecule is challenging. In a recent study, MRSEC scientists did this for the molecule crystal violet (CV) by generating a sample that had an equal number of CV molecules mixed with deuteriated CV’s (CV-d0 and CV-d12). The SERS spectra are almost identical, but a few lines are unique to one isotope or the other. By using computational methods to assign the isotopes, it was demonstrated that in most experiments, only one of the two isotopes was present. Kleinman, J. Amer. Chem. Soc. 113, 4115-22

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