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Chap44 Diabetes insipidus and aquaporin (ADH, aldosterone and ACTH)

Chap44 Diabetes insipidus and aquaporin (ADH, aldosterone and ACTH). B9902036 洪健睿 B9902045 許仲皓. Diabetes insipidus (DI). Frequency ： uncommon, with a prevalence of 1 case per 25,000 population (as in the United States). Signs and symptoms ：

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Chap44 Diabetes insipidus and aquaporin (ADH, aldosterone and ACTH)

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  1. Chap44Diabetes insipidus and aquaporin (ADH, aldosterone and ACTH) B9902036洪健睿 B9902045許仲皓

  2. Diabetes insipidus (DI) Frequency： uncommon, with a prevalence of 1 case per 25,000 population(as in the United States). Signs and symptoms： polydipsia ：extreme thirst (especially for cold or ice water) polyuria ：excretion of large amounts of severely diluted urine

  3. Diabetes insipidus (DI) Central (neurogenic) DI： decreased secretion of  antidiuretic hormone (ADH) in the brain. Nephrogenic DI： inability of the kidney to respond normally to ADH.

  4. Antidiuretic Hormone (ADH) arginine vasopressin V2 receptor (AVPR2) aquaporin-2 water channel(AQP2)

  5. Causes of Nephrogenic DI Acquired (most common) Hereditary：

  6. Aquaporin The mutation of AQP2 gene causes： 1. misfolding of mutant aquaporin-2 water channels 2. unsuccessful AQP2 transition in the ER AQP2

  7. Renin-Angiotensin-Aldosterone System

  8. Aldosterone epithelial sodium channel transcription factor intracellular receptor sodium-potassium pump (steroid ligand)

  9. ADH vs. RAAS

  10. Adrenocorticotropic Hormone (ACTH) Adrenal gland Kidney ex. Aldosterone Anterior Pituitary Hormone Tropic Hormone： targets endocrine glands adrenal cortex Adrenal Cortex： secretescorticosteroids glucocorticoids mineralocorticoids Severe stress rises the blood ACTH level

  11. References Campbell N. A., Reece J. B., and Mitchell L.G. Biology 8th ed. Benjamin/Cummings. 2008. Campbell N. A and Reece J. B. 生物學第六版(下冊), 偉明圖書有限公司, 2007 http://emedicine.medscape.com/article/117648-overview http://www.bhp-gc.tw/index.php?mo=DiseasePaper&action=paper1_show&cate=Set1&csn=72&sn=250 http://en.wikipedia.org/wiki/Nephrogenic_diabetes_insipidus#Hereditary http://www.ncbi.nlm.nih.gov/omim/304800 http://www.ndif.org/public/pages/1-Introduction http://zh.wikipedia.org/wiki/尿崩症 http://g.wanfangdata.com.hk/Service/File/File.ashx?fileid=Periodical_zhszb98201004011&pay=True&sign=0A8EAE9400DDAA5203A42726CBDD22E85B7575C6103822BCD877A758592162722AC491A1DB9B07123F5CD4D5A7A5782BE6858C0B0B6968D94FF44170C015FDEE65ECAB4BDCC7B6C5B3E3B857B8315E20D21DD5F6E74EC8B3D3868FD9F27AE42B64A889ABCE3EEB8A2D878D765F72098D7A6DBEC837B3E53042DA4E6C7655B292&Type= http://www.differencebetween.net/science/health/difference-between-adh-and-aldosterone/ http://en.wikipedia.org/wiki/Aldosterone http://hyper.ahajournals.org/content/vol52/issue4/cover.shtml

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