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  1. Okura Ken; Matsuoka Shigeru; GotoRyosuke; Inoue Masayuki The twisted side chain of antillatoxin is important for potent toxicity: total synthesis and biological evaluation of antillatoxin and analogues. AngewandteChemie (International ed. in English) (2010), 49(2), 329-32.

  2. Antillatoxin is a marine cyanobacterial toxin that potently activates voltage-gated sodium channels. Link Link Link

  3. Chemical biology is the use of chemistry, usually through small molecules made synthetically, to solve biological problems and to manipulate biological systems.

  4. MukaiyamaAldol Addition

  5. Mechanism of the MukaiyamaAldol Addition

  6. Pyrrolidine =

  7. Enamine Formation Link

  8. Reactivity: Similar Trends for Reactivity of Enols, Enamines, and Enolates

  9. Reactivity of Enamines parallels that of Enolates

  10. EDC = 1-Ethyl-3- (Dimethylaminopropyl)carbodiimide

  11. mCPBA = meta-chloroperoxybenzoic acid

  12. Pummerer Rearrangement

  13. Mechanism of the Pummerer Rearrangement

  14. BOC protecting group

  15. Dppf = Diphenylphosphinoferrocene

  16. Suzuki Coupling Reaction Miyaura, Norio; Yamada, Kinji; Suzuki, Akira. A new stereospecific cross-coupling by the palladium-catalyzed reaction of 1-alkenylboranes with 1-alkenyl or 1-alkynyl halides. Tetrahedron Letters (1979), (36), 3437-40.

  17. Mechanism of Suzuki Coupling Reaction