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Huntington s Disease

Summary of Huntington's Disease. Overview and Symptoms:Occurs from the genetically programmed degeneration of nerve cellsCauses uncontrolled movement, lose of intellectual faculties, and emotional disturbanceInteresting Facts:No family history found in 1-3% of people with Huntington's DiseaseHG

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Huntington s Disease

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    1. Huntingtons Disease! Hamza Khan Jeremy Tague Period 2 January 29, 2010

    2. Summary of Huntingtons Disease Overview and Symptoms: Occurs from the genetically programmed degeneration of nerve cells Causes uncontrolled movement, lose of intellectual faculties, and emotional disturbance Interesting Facts: No family history found in 1-3% of people with Huntingtons Disease HG will definitely affect your life if one is inherited with the HG gene.

    3. Location Located in the Autosomal Chromosome Not a Sex Chromosome (Not X-Linked) Localized on the 4th Autosomal chromosome pair. Chromosome #4 Located in every chromosome except for sex chromosomes

    4. Mode of Inheritance Inherited disease (Autosomal Dominant) From parent to child Each child has 50% chance of inheriting the disease If child does not develop disease they cannot pass it on to later generation.

    5. Alleles Each person has 2 alleles per gene. We represent dominant alleles by a capital letter We represent recessive alleles by a small letter HH means they have 2 bad genes Hh means they have 1 bad gene, and 1 good gene hh means they have 2 good genes

    6. Punnett Squares Ratio of the chance of offspring inheriting Huntingtons Disease; ratio determined by parents Each punnett square represents the chances PER CHILD

    7. Probability Using Ratios and Percentages Ratios: Must equal 4; 4 possibilities Ratio is lined up in this format: Homozygous dominant : heterozygous dominant : homozygous recessive ex: 1 : 2 : 1 ex: 1HH : 2Hh : 1hh Percentages: Must equal 100; each possibility equals 25% Put percentages into the ratio ex: 25% : 50% : 25% ex: 25%HH : 50%Hh : 25%hh

    8. What Do These Letters Mean?! H= dominant allele Huntingtons Disease; h=recessive allele no Huntingtons Disease Phenotype what you see HH= Huntintons Disease is present Hh= Huntingtons Disease is present ( also there is a no Huntingtons Disease carrier) hh= no Huntingtons Disease Genotype what is in the genes HH= Homozygous dominant(Huntingtons Disease) Hh= Heterozygous dominant(Huntingtons Disease) hh= Homozygous recessive(no Huntingtons Disease)

    9. Genotype and Phenotype Probability Phenotype: Ratios: 3 HH: 1 no HH Percentages: 75% HH: 25% no HH Genotype: Ratios: 1HH : 2Hh : 1hh Percentages: 25%HH : 50%Hh : 25%hh

    10. Student Practice Phenotype: Ratio: Percentage: Genotype: Ratio: Percentage:

    11. Pedigree

    12. STUDENT PRACTICE! Circle: Male Square: Female: Red: White: Red/White:

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