Protein Sorting. ISAT 351, Spring 2004 College of Integrated Science and Technology James Madison University. Intracellular Compartments and Protein Sorting. Many chemical reactions in the cell are mutually incompatible (protein synthesis and degradation)
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ISAT 351, Spring 2004
College of Integrated Science and Technology
James Madison University
Why is this so?
Amino acid sequence defines protein fate
Some proteins synthesized in cytosol , then transported; other proteins complete synthesis at organelle
Post-translational modification of protein
Gradient of immature-to-mature protein may be localized in compartments
1. Transport through pores (nucleus)
2. Transport across membranes (chloroplast and mitochondria)
3. Transport by vesicles (ER and Golgi)
Specialized phagocytic cells (e.g., macrophages) can ingest invading microorganisms