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Inter- and Intra-Individual Differences in Auditory Gating: Insights from Schizophrenia Research

This project explores sensory gating capabilities in individuals with schizophrenia compared to healthy controls. Utilizing double stimulus paradigms, the study examines the ability to suppress irrelevant auditory stimuli, indicated by P300 responses. Collaborating with experts from psychiatry and cognitive science, we aim to identify potential deficits in gating mechanisms among schizophrenia patients. Supported by NIH/NIMH and NSF, our findings highlight critical variations in neurophysiological responses, contributing to the understanding of auditory processing in mental health disorders.

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Inter- and Intra-Individual Differences in Auditory Gating: Insights from Schizophrenia Research

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  1. U H

  2. CogSci Projects for Spring 2005.

  3. Inter- and Intra-Individual Gating Differences. Ben H.Jansen Department of Electrical and Computer Engineering, and Center for Neuro-Engineering and Cognitive Science, University of Houston, Texas bjansen@uh.edu Collaborators: Nashaat N Boutros, MD, Dept. Psychiatry, Yale U; Lingli Hu, Bharat Bonala, Karthik Sundaresan, Prashant Kota,Hitesh Doshi, Vijay Grandhi, Gopal Agarwal, Ruben Jacob, Anant Hegde, Darshan Iyer, Violet Garoosi Supported by NIH/NIMH R01 MH58784, NSF/REU and UH-GEAR

  4. P200 P50 mV 8 6 S1 S2 4 2 0 -100 -50 0 50 100 150 200 250 300 -2 ms -4 -6 stim N100 Sensory Gating Gating: ability to suppress irrelevant stimuli Double Stimulus Paradigm: • Two identical tone bursts 0.5 s apart • S1 response larger than S2

  5. 8 8 S1 S2 6 6 NC NC SZ SZ 4 4 2 2 0 0 -100 -50 0 50 100 150 200 250 300 -100 -50 0 50 100 150 200 250 300 -2 -2 -4 -4 -6 -6 Gating Deficits in Schizophrenia? mV mV ms ms

  6. 8.0s 0.5s • Double Clicks: • A: identical • B, C: non-identical • Trains: • F, G: S1=…=S5=S6 S1 S2 S1 S2 S1 S2 8.0s S1 … S5 S6 S1 … S5 S6 / Paradigms and Data Set • 16 normal subjects, 17 schizophrenia patients. • Max. 4 sessions/subject • Cz-linked ears, Artifacts removed • Paradigms:

  7. mV P200 A B C F G N100 NC SZ P50 S2 S2 S1 S2 S1 S1 S1 and S2 Grand Average Amplitudes: Paradigms

  8. 71 51 53 83 56 58 5 5 A 0 0 -5 -5 0 100 200 300 400 500 0 100 200 300 400 500 5 5 F 0 0 -5 -5 0 100 200 300 400 500 0 100 200 300 400 500 5 5 G 0 0 -5 -5 0 100 200 300 400 500 0 100 200 300 400 500 5 5 B 0 0 -5 -5 0 100 200 300 400 500 0 100 200 300 400 500 5 5 C 0 0 -5 -5 0 100 200 300 400 500 0 100 200 300 400 500 Gating in Normal Controls S1 S2 P50 N100 P200

  9. 831 72 73 91 85 80 5 5 A 0 0 -5 -5 0 100 200 300 400 500 0 100 200 300 400 500 5 5 B 0 0 -5 -5 0 100 200 300 400 500 0 100 200 300 400 500 5 5 C 0 0 -5 -5 0 100 200 300 400 500 0 100 200 300 400 500 5 5 F 0 0 -5 -5 0 100 200 300 400 500 0 100 200 300 400 500 5 5 G 0 0 -5 -5 0 100 200 300 400 500 0 100 200 300 400 500 Gating in Schizophrenia S1 S2 P50 N100 P200 1Red means greater than NC

  10. AUDITORY P300Bharat Bonala, Prashant Kota, Karthik Sunderasan, Nashaat N Boutros, and Ben H Jansen • Differences between normal and schizophrenia subjects. • Brain-Machine Interface.

  11. P300 and the Odd-Ball Paradigm 2 sec F F F R F F R F R F F Frequent/Non-Target stimulus P300: response to a relevant, infrequently occurring stimulus. R Rare/Target stimulus

  12. Normal Controls have larger P300 than Schizophrenia Patients

  13. A A B B C C D D E E F F G G H H I I K K L L J J A B C D E F M M N N Q Q R R O O P P G H I K L J U U V V W W X X T T S S M N Q R O P 3 3 4 4 Y Y Z Z 1 1 2 2 U V W X T S -- -- 5 5 6 6 7 7 8 8 9 9 3 4 Y Z 1 2 -- 5 6 7 8 9 Using the BMI HUNGRY HUNGRY THIRSTY THIRSTY LIGHT ON LIGHT ON LIGHT OFF LIGHT OFF Spelling Machine Donchin et al, IEEE-T-BME, 2000

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