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Nama : Prof. dr. Iwan Dwiprahasto , MMedSc , PhD Riwayat pendidikan PowerPoint Presentation
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Nama : Prof. dr. Iwan Dwiprahasto , MMedSc , PhD Riwayat pendidikan - PowerPoint PPT Presentation


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Curriculum vitae. Nama : Prof. dr. Iwan Dwiprahasto , MMedSc , PhD Riwayat pendidikan Dokter , FK UGM tahun 1987 S-2: MMedSc ( Farmakoepidemiologi ), Newcastle University Australia, 1993 S-3: PhD, London School of Hygiene & Tropical Medicine, England, 2000 Jabatan :

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slide1

Curriculum vitae

  • Nama : Prof. dr. IwanDwiprahasto, MMedSc, PhD
  • Riwayatpendidikan
  • Dokter, FK UGM tahun 1987
  • S-2: MMedSc (Farmakoepidemiologi), Newcastle University Australia, 1993
  • S-3: PhD, London School of Hygiene & Tropical Medicine, England, 2000
  • Jabatan:
  • Wakil Rektor Bidang Akademik dan Kemahasiswaan UGM
  • Ketua Umum PB IKAFI (Ikatan Farmakologi Indonesia)
  • Director, Clinical Epidemiology & Biostatistics Unit FK UGM
  • Co-chairman, Indonesian Clinical Epidmiology & EBM Network
  • Board of Governor, International Clinical Epidemiology Network (INCLEN)
  • Dewan Pakar Asosiasi Rumah Sakit Daerah (ARSADA)
  • Dewan Pakar Perhimpunan Rumah Sakit Indonesia (PERSI)
  • Ketua Tim Ahliuntuk DPHO, PT Askes Indonesia
  • KomiteBersama UjiKompetensiDokter Indonesia (KBUKDI)
  • Ketua, Komite Nasional (KOMNAS) DOEN (DaftarObatEsensialNasional)
  • Ketua, Tim Ahli Penyusun Formularium Jamkesmas
  • Komite Nasional (KOMNAS) Penilai Obat Jadi Badan POM
  • Komite Nasional (KOMNAS) Informatorium Obat Nasional Indonesia (IONI)
  • Komite Nasional (KOMNAS) Obat Tradisional dan Suplemen Makanan
farmakoterapi infeksi odontogenik fokus pada antibiotika

Farmakoterapi Infeksi Odontogenik: Fokus pada antibiotika

IwanDwiprahasto

Bagian Farmakologi & Terapi FK UGM

slide6

Celullitis

Abses

Fistula

slide13

2. Farmakokinetik – Farmakodinamik (PK/PD)

Kadar antibiotika dalam darah setelah pemberian teratur tiap 8 jam

Cmax

Kadar obatdalamdarah

MTC

Kadar terapetik

MIC

07.00

15.00

23.00

07.00

Waktu pemberian antibiotika

slide14

Kadar antibiotikadalamdarahsetelahpemberianteraturtiap 8 jam

Cmax

Tidakada

obat

didalam

darah

Kadar obat dalam darah

MTC

MIC

7

1300

15

1900

23

700

Waktu pemberian antibiotika

slide15

Eradikasi bakteri oleh antibiotika tidak pernah mencapai 100%

Clinical Trials in Pediatric Patients With Acute Bacterial Otitis Media: Ceftriaxone vs competitor

slide19

Parameter penting PK/PD

8

Drug A

6

Drug A

Drug B

Drug B

Antibiotic concentration (ug/ml)

4

2

B

B

0

Time

A

Time above MIC

penggunaan fluoroquinolone dan resistensi pneumococc us
Penggunaan Fluoroquinolonedan Resistensi Pneumococcus

5

6

Age 15-64y

5

4

Age >65y

FQ Scripts

4

3

Pneumococci with Reduced

Susceptibility to Fluoroquinolones (%)

No. of Prescriptions per 100 Persons

3

2

2

1

1

0

0

1988

1989

1990

1991

1992

1993

1994

1995

1996

1997

1998

Year

Chen DK, et al. N Engl J Med. 1999;341(4):233-239.

fq resistance vs fq use
FQ Resistance vs FQ Use

PA (r=0.976; p<0.001)

GNB (r=0.891; p<0.001)

Neuhauser MM, JAMA 2003;289:885

interaksi doxycycline fe

4. Adverse drug reaction & Drug interactions

Interaksi Doxycycline-Fe

mcg/ml

Doxycycline 200 mg

Doxycycline + Fe

Waktu: Jam

kadar simvastatin
Kadar Simvastatin

Simvastatin (ng/ml)

Simvastatin + Eritromisin

Simvastatin + Verapamil

Simvastatin + Plasebo

Waktu (jam)

slide33

Knowing is not enough; we must apply.

Willing is not enough; we must do.