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The inferior olivary nucleus is the only source of cerebellar climbing fibers PowerPoint Presentation
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The inferior olivary nucleus is the only source of cerebellar climbing fibers

The inferior olivary nucleus is the only source of cerebellar climbing fibers

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The inferior olivary nucleus is the only source of cerebellar climbing fibers

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  1. I V I V

  2. The inferior olivary nucleus is the only source of cerebellar climbing fibers

  3. The InferiorOlive nucleus

  4. Olivary neurons (Ramon Y Cajal)

  5. HRP filled olivary neuron Intracellular labeling of olivary neuron

  6. Action potential in olivary neuron

  7. Action potentials in olivary neuron

  8. The effect of TTX on action potentials in olivary neuron

  9. The effect of Mn2+ and Cd2+ on action potentials in olivary neuron

  10. -55 mV -60 mV -60 mV 15 mV -68 mV 1 nA 20 msec Two types of action potentials in olivary neuron -60 mV 15 mV

  11. The Na+ and Ca2+ components of the two types of action potentials

  12. TTX Independent activation of the action potentials

  13. Refractory period of the action potentials

  14. 10 mV Refractory period of the action potentials

  15. The Inactivation curve of the low threshold action potential

  16. Possible mechanism of rhythmic activity Ionic currents in Olivary neurons: Na current – typical H&H current Dendritic Ca current – high threshold non-inactivating Ca dependent, K current Somatic Ca current – low threshold inactivating

  17. Possible mechanism of rhythmic activity

  18. Cell 2 Cell 1 20 mV Cell 1 Cell 2 5 mV 200 ms 20 mV Cell 1 10 mV 2 mV Cell 2 100 ms 200 ms 5 10 mV Electrical coupling between olivary neuron Cell 1 Cell 2

  19. Dye coupling between olivary neuron

  20. The olivary glumerulus

  21. Olivary Gapjunction