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Pre- Tx T1+C. POSITRON EMISSION TOMOGRAPHY PARAMETRIC RESPONSE MAP (PET-PRM). IOIS: 3401. Pre- Tx 18 F-FDOPA PET. Post- Tx 18 F-FDOPA PET. Difference Post-Pre Tx 18 F-FDOPA PET. RESPONDER. Change in 18 F-FDOPA Signal. - Decrease. + Increase.

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slide1

Pre-Tx T1+C

POSITRON EMISSION TOMOGRAPHY PARAMETRIC RESPONSE MAP (PET-PRM)

IOIS: 3401

Pre-Tx18F-FDOPA PET

Post-Tx18F-FDOPA PET

Difference Post-Pre Tx18F-FDOPA PET

RESPONDER

Change in 18F-FDOPA Signal

- Decrease

+ Increase

Benjamin M. Ellingson, Ph.D., Dept. of Radiological Sciences, David Geffen School of Medicine at UCLA, 2011

slide2

Pre-Tx T1+C

POSITRON EMISSION TOMOGRAPHY PARAMETRIC RESPONSE MAP (PET-PRM)

IOIS: 3401

Difference Post-Pre Tx18F-FDOPA PET

Change in 18F-FDOPA Signal

- Decrease

+ Increase

Benjamin M. Ellingson, Ph.D., Dept. of Radiological Sciences, David Geffen School of Medicine at UCLA, 2011

slide3

Pre-Tx T1+C

POSITRON EMISSION TOMOGRAPHY PARAMETRIC RESPONSE MAP (PET-PRM)

IOIS: 2383

Pre-Tx18F-FDOPA PET

Post-Tx18F-FDOPA PET

Difference Post-Pre Tx18F-FDOPA PET

NON-RESPONDER

Change in 18F-FDOPA Signal

- Decrease

+ Increase

Benjamin M. Ellingson, Ph.D., Dept. of Radiological Sciences, David Geffen School of Medicine at UCLA, 2011

slide4

Pre-Tx T1+C

POSITRON EMISSION TOMOGRAPHY PARAMETRIC RESPONSE MAP (PET-PRM)

IOIS: 2383

Difference Post-Pre Tx18F-FDOPA PET

NON-RESPONDER

Change in 18F-FDOPA Signal

- Decrease

+ Increase

Benjamin M. Ellingson, Ph.D., Dept. of Radiological Sciences, David Geffen School of Medicine at UCLA, 2011

slide5

POSITRON EMISSION TOMOGRAPHY PARAMETRIC RESPONSE MAP (PET-PRM)

RESPONDER

Pre-Tx DOPA Tumor Volume = 117.5 mL

DOPA

PRM

% Decreasing DOPA Uptake = 93.0%

% Increasing DOPA Uptake = 7.0 %

Change in 18F-FDOPA Signal

- Decrease

+ Increase

Pre-Tx DOPA Tumor Volume = 18.3 mL

NON-RESPONDER

DOPA

PRM

% Decreasing DOPA Uptake 72.8%

% Increasing DOPA Uptake = 27.2 %

Benjamin M. Ellingson, Ph.D., Dept. of Radiological Sciences, David Geffen School of Medicine at UCLA, 2011

slide6

POSITRON EMISSION TOMOGRAPHY PARAMETRIC RESPONSE MAP (PET-PRM)

RESPONDER

All Changes

> 25% Change

> 50% Change

% Decreasing DOPA Uptake = 93.0%

% Decreasing > 25% change = 47.9%

% Decreasing > 50% change = 18.2%

% Increasing DOPA Uptake = 7.0 %

% Increasing > 25% change = 0.9%

% Increasing > 50% change = 0.0%

% Change in 18F-FDOPA Signal

- 100%

+ 100%

Benjamin M. Ellingson, Ph.D., Dept. of Radiological Sciences, David Geffen School of Medicine at UCLA, 2011

slide7

POSITRON EMISSION TOMOGRAPHY PARAMETRIC RESPONSE MAP (PET-PRM)

NON-RESPONDER

All Changes

> 25% Change

> 50% Change

% Decreasing DOPA Uptake = 72.8%

% Decreasing > 25% change = 31.9%

% Decreasing > 50% change = 2.7%

% Increasing DOPA Uptake = 27.2 %

% Increasing > 25% change = 3.2%

% Increasing > 50% change = 0.05%

% Change in 18F-FDOPA Signal

- 100%

+ 100%

Benjamin M. Ellingson, Ph.D., Dept. of Radiological Sciences, David Geffen School of Medicine at UCLA, 2011

slide8

POSITRON EMISSION TOMOGRAPHY PARAMETRIC RESPONSE MAP (PET-PRM)

% Decreasing DOPA

% Increasing DOPA

Benjamin M. Ellingson, Ph.D., Dept. of Radiological Sciences, David Geffen School of Medicine at UCLA, 2011

slide9

POSITRON EMISSION TOMOGRAPHY PARAMETRIC RESPONSE MAP (PET-PRM)

RESPONDER

VOLUME OF DECREASING DOPA UPTAKE = 175.5 mL

VOLUME OF INCREASING DOPA UPTAKE = 0.8 mL

NON-RESPONDER

VOLUME OF DECREASING DOPA UPTAKE = 7.4 mL

VOLUME OF INCREASING DOPA UPTAKE = 1.2 mL

Change in 18F-FDOPA Signal

- Decrease

+ Increase

Benjamin M. Ellingson, Ph.D., Dept. of Radiological Sciences, David Geffen School of Medicine at UCLA, 2011

slide10

XXXX

18F-FDOPA PET Parametric Response Maps (PET PRMs)

Change in PET Signal

-5000

+ 5000

Baseline: 3/10/09

10/20/09

3/30/10

10/12/10

2/15/11

Benjamin M. Ellingson, Ph.D., Dept. of Radiological Sciences, David Geffen School of Medicine at UCLA, 2011

slide11

XXXX

18F-FDOPA PET Parametric Response Maps (PET PRMs)

Baseline: 3/10/09

Benjamin M. Ellingson, Ph.D., Dept. of Radiological Sciences, David Geffen School of Medicine at UCLA, 2011

slide12

Pre-Tx T1+C

MALIGNANT MARKER MAPS (18F-FLT and 18F-FDOPA )

IOIS: 3401

Pre-Tx18F-FDOPA PET

Pre-Tx18F-FLT PET

Combined 18F-FLT and 18F-FDOPA

FLT

DOPA

FLT+DOPA

Benjamin M. Ellingson, Ph.D., Dept. of Radiological Sciences, David Geffen School of Medicine at UCLA, 2011

slide13

MALIGNANT MARKER MAPS (18F-FDOPA + CBV + ADC )

Benjamin M. Ellingson, Ph.D., Dept. of Radiological Sciences, David Geffen School of Medicine at UCLA, 2011