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Learn about the syndromic approach to diagnosing and managing sexually transmitted diseases (STDs) such as genital herpes, chancroid, LGV, and donovanosis. Focus on condyloma acuminatum (genital warts) caused by HPV, including its etiology, clinical features, diagnosis, and treatment options.
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Sexually transmitted disease • Unit 9 • – CA/Genital Herpes/Chancroid/LGV/Donovanosis • – Syndromic approach to the diagnosis and • management of STDs
Etiology • HPV - More than 100 different types • 30-40 types can infect the genital area - genital warts: type 6, 11, 16 and 18 - cervical neoplasia associated: 16, 18, 31, 33, 35 • high-risk HPV types - risk factor of cervical neoplasia • HPV + HSV - good predictor of cervical cancer.
Transmission • Direct contact - Genital-Genital - Oral-Genital - Oral-Oral - Hand-Mouth • Indirect contact
Clinical features 1. Incubation time: mean 3 months (3 weeks - 8 months) 2. Asymptomatic or pruritus /discharge 3. Lesions - pearly, filiform, papillary, cauliflower - skin colored, pale, pink or grey
Diagnosis • History • Clinical features - In moist areas: pink or red, with a rough cauliflower-like appearance. - On dry skin: small, hard and gray, resembling ordinary warts. - Acetic acid test: 5%
Histological • Epithelial hyperplasia • Acanthosis • Papillomatosis • Koilocytes
Differential diagnosis • Condylomata lata • Pseudo condyloma • Pearly penile papules • Bowenoid papulosis
Condylomata lata Treponema pallidum tend to be smoother, moist, more rounded Darkfield (+) STS (+) • Condylomata acuminata HPV rough, "warty"appearing, filiform, pedunculated, resemble a cauliflower Darkfield (-) STS (-)
Pseudo condyloma on Labia majora Pearly penile papules Physical ectopic condition Small, smooth, skin-colored papules on the penis Asymptomatic, asymerically distributed
Bowenoidpapulosisa benign cutaneous proliferationassociated with HPVhyperpigmented papules mm~cmasymptomatic tend to spontaneously regress in months
Treatment Patient-Applied - Podophyllin 0.5% sol. - Imiquimod 5% cream Provider-Administered - Cryotherapy - Trichloroacetic acid (TCA) 80-90% - Intralesional interferon - ALA photodynamic therapy
Treatment Surgical treatments - electrocauterization - laser therapy - surgical excision
Treatment • Sexual partners be examined and treated • Follow-up examination /self examination