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Management of Genital Warts: Diagnosis, Treatment, and Follow-up

Learn about the syndromic approach to diagnosing and managing sexually transmitted diseases (STDs) such as genital herpes, chancroid, LGV, and donovanosis. Focus on condyloma acuminatum (genital warts) caused by HPV, including its etiology, clinical features, diagnosis, and treatment options.

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Management of Genital Warts: Diagnosis, Treatment, and Follow-up

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  1. Sexually transmitted disease • Unit 9 • – CA/Genital Herpes/Chancroid/LGV/Donovanosis • – Syndromic approach to the diagnosis and • management of STDs   

  2. Condyloma Acuminatum(Genital Warts)

  3. Etiology • HPV - More than 100 different types • 30-40 types can infect the genital area - genital warts: type 6, 11, 16 and 18 - cervical neoplasia associated: 16, 18, 31, 33, 35 • high-risk HPV types - risk factor of cervical neoplasia • HPV + HSV - good predictor of cervical cancer.

  4. Transmission • Direct contact - Genital-Genital - Oral-Genital - Oral-Oral - Hand-Mouth • Indirect contact

  5. Clinical features 1. Incubation time: mean 3 months (3 weeks - 8 months) 2. Asymptomatic or pruritus /discharge 3. Lesions - pearly, filiform, papillary, cauliflower - skin colored, pale, pink or grey

  6. Diagnosis • History • Clinical features - In moist areas: pink or red, with a rough cauliflower-like appearance. - On dry skin: small, hard and gray, resembling ordinary warts. - Acetic acid test: 5%

  7. Histological • Epithelial hyperplasia • Acanthosis • Papillomatosis • Koilocytes

  8. Differential diagnosis • Condylomata lata • Pseudo condyloma • Pearly penile papules • Bowenoid papulosis

  9. Condylomata lata Treponema pallidum tend to be smoother, moist, more rounded Darkfield (+) STS (+) • Condylomata acuminata HPV rough, "warty"appearing, filiform, pedunculated, resemble a cauliflower Darkfield (-) STS (-)

  10. Pseudo condyloma on Labia majora Pearly penile papules Physical ectopic condition Small, smooth, skin-colored papules on the penis Asymptomatic, asymerically distributed

  11. Bowenoidpapulosisa benign cutaneous proliferationassociated with HPVhyperpigmented papules mm~cmasymptomatic tend to spontaneously regress in months

  12. Treatment Patient-Applied - Podophyllin 0.5% sol. - Imiquimod 5% cream Provider-Administered - Cryotherapy - Trichloroacetic acid (TCA) 80-90% - Intralesional interferon - ALA photodynamic therapy

  13. Treatment Surgical treatments - electrocauterization - laser therapy - surgical excision

  14. Treatment • Sexual partners be examined and treated • Follow-up examination /self examination

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