Brain… The Final Frontier…. Lets go on a “Fantastic Voyage”. Gene Expression. Transmitter Synthesis. Permeability. Neurotransmission. Reuptake. Blood Flow. Metabolism. Receptor Binding. With PET we can image at the site of “thinking”. Dopaminergic synapse. (18)F-FBAU . 18F-FDOPA.
which is which ?
What the PET scanner sees
(d)The modeling process
Imagine a living brain
Consider the relevant neurochemistry
Describe exchange between pools by a series of differential equations
Abstract the neurochemistry into a series of connected pools
Morris, E.D., C.J. Endres, K. Schmidt, B.T. Christian, R.F. Muzic, R.E. Fisher. Kinetic Modeling in PET. In Emission Tomography: The Fundamentals of PET and SPECT, ed. M. Wernick and N. Aarsvold. Academic Press. Amsterdam, Netherlands, 2004, pp. 499-540.