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Brain… The Final Frontier…. Lets go on a “Fantastic Voyage”. Gene Expression. Transmitter Synthesis. Permeability. Neurotransmission. Reuptake. Blood Flow. Metabolism. Receptor Binding. With PET we can image at the site of “thinking”. Dopaminergic synapse. (18)F-FBAU . 18F-FDOPA.

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Presentation Transcript
lets go on a fantastic voyage
Lets go on a “Fantastic Voyage”

Gene Expression

Transmitter Synthesis

Permeability

Neurotransmission

Reuptake

Blood Flow

Metabolism

Receptor Binding

with pet we can image at the site of thinking
With PET we can image at the site of “thinking”

Dopaminergic synapse

(18)F-FBAU

18F-FDOPA

15O-[H2O]

11C-raclopride, etc

11C-CFT

15O-[H2O]

18F-FDG

11C-raclopride

what s all this about models in pet
What’s all this about models in PET?

Dopaminergic synapse

Plasma raclopride

Free raclopride

Bound raclopride

‘stuck’ raclopride

how can we tell which radioactivity comes from free tracer bound tracer plasma borne tracer
How can we tell which radioactivity comes from Free tracerBound tracerPlasma-borne tracer?
tracer in each state has a unique temporal trajectory
Tracer in each state has a unique temporal trajectory

which is which ?

tracer concentration

What the PET scanner sees

Bound

Free

Plasma

Time (minutes)

the modeling process

(a)

(b)

P

F

B

N

(c)

(d)

The modeling process

Imagine a living brain

Consider the relevant neurochemistry

Describe exchange between pools by a series of differential equations

Abstract the neurochemistry into a series of connected pools

Morris, E.D., C.J. Endres, K. Schmidt, B.T. Christian, R.F. Muzic, R.E. Fisher. Kinetic Modeling in PET. In Emission Tomography: The Fundamentals of PET and SPECT, ed. M. Wernick and N. Aarsvold. Academic Press. Amsterdam, Netherlands, 2004, pp. 499-540.