Presentation on ITP By James Runco . “Everyone bleeds sometimes, I just bleed more.” . ITP . ITP stands for Idiopathic Thrombocytopenic Purpura but it is also frequently called: Immune Thrombocytopenic Purpura or Idiopathic Thrombocytopenia. Background Information .
“Everyone bleeds sometimes,
I just bleed more.”
ITP stands for
Idiopathic Thrombocytopenic Purpura
but it is also frequently called:
Immune Thrombocytopenic Purpura or
There are three Basic types of blood cells made in the marrow of the bones each with their own specialized jobs.
Red Blood Cells (Rbc’s) Carry Oxygen
White Blood Cells (Wbc’s) Protect your body from infection
Platelets (Plt’s) Help your help your body to heal injuries
ITP is an autoimmune disease during which your body’s immune system attacks and destroys your platelets.
The body releases auto-antibodies which chemically tag its’ own cells as foreign
White blood cells then seek out and destroy platelets as if they were fighting an infection
This causes a rapid drop in the level of platelets in a person’s body
This Thrombocytopenia (lowered platelet level) is Idiopathic, (without known cause) and can be triggered at any time.
Platelets are a specialized form of blood cells that are absolutely essential for your blood to clot.
When they are attacked by the White Blood cells it can be disastrous.
Your body is left unable to mend any cuts or stop bleeding even from the smallest internal injuries
ITP is accompanied by short term or more permanent depression.
This is because 2% of the body’s serotonin is stored in the platelets; when the platelets are destroyed so is this mood elevating neurotransmitter.
Platelets also carry Serotonin’s “parent” chemical called L-Tryptophan
This L-Tryptophan is able to pass through the blood brain barrier, so it’s loss is the probable cause of the sleep/ eating irregularities.
The exact causes of ITP are as yet unknown, but there is currently research going on to try and determine what causes this disease.
There are many theories, most state that ITP is a multifactorial disease with a strong genetic predisposition.
Researchers are currently looking for multiple instances of ITP in a family, and have found that in some cases ITP can be passed from mother to child.
There seems to be a connection between ITP and pregnancy. A previously normal woman can sometimes develop ITP during a pregnancy.
Pregnancies are much more dangerous for women with ITP, both because their platelet counts can drop and because of the bleeding involved with delivery.
Three most common theories for ITP are:
ITP is often the Diagnosed by its’ symptoms. It is frequently the diagnosis when all other blood diseases are ruled out and there seems to be the body mounting an attack against the platelets
There are different forms of ITP. Some children experience a disease which is listed as ITP because it is thrombocytopenia with an unknown origin. However it differs from adult and chronic childhood ITP because many of these childhood cases last only a matter of months and then go into permanent remission.
In most cases ITP is not fatal and can be treated.
There is a wide variety of treatment options, but with only partial success due to the unknown nature of the disease.
The most commonly excepted, and most successful treatments for ITP involve the removal of the spleen because it is a site for autoantibody production.
People are also very commonly given Prednisone which is an artificial steroid which can enhance platelet production
For emergency case treatment (normally when platelets get below 20,000) They will administer IV G or intravenous gammaglobulin for several days, and they wait for counts to rebound
Platelet Disorder Support Association www.ITPpeople.com
Scripps Institute website http://seconde.scripps.edu/ltp