DIABETES MELLITUS HOLISTIC NATURAL HEALTHCARE

1. DIABETES MELLITUS HOLISTIC NATURAL HEALTHCARE Lecture presented at the Comprehensive Workshop on Diabetes Management Organized by KPJ Healthcare University College 28th & 29th August 2013 Bayview Beach Resort, Batu Ferringhi, Penang Prof. Dr. Ananthan Krishnan Consultant Pharmacist & Naturopath Department of Research and Study AK PHARMACY & NATUROPATHY CENTRE Healing Diseases is Progressive Science Preventing Illness is Ultimate Wisdom Prof. Dr. Ananthan Krishnan

3. Holistic Natural Healthcare Model of Diabetes Mellitus Type 2 Introduction To say that each human being yearns and prays for good health is to utter a platitude. Good health is what the people of the world want ; poor health, illness or injury is the dreaded of things , and no human being wants to be a victim of diseases. Health is treasured and cherished by all, yet it is most often taken for granted . Only when health is lost, the desperation to heal oneself starts. To understand human health and how to remain healthy must be the pre-eminent duty of each human being. One must learn to the best of his or her ability, every knowledge of what health is, how to maintain good health and prevent the early onset of illness in life. To know human health well , one has to understand the nature of the human being.

4. The Natural Healthcare and Healing Approach BIO - ENERGENOMICS MODEL OF DIABETES MELLITUS THE COSMIC PERPECTIVE

5. Philosophy, Concepts and Principles of Disease Existence : Diabetes Mellitus Its Nature and Reality Among the health disorders that abound in human society, resulting from the twin causes of genetic weakness and improper management of human life process is Diabetes Mellitus Type 2. First principle of Disease Existence is the cosmic fact that diseases and injury are natural realities, and their existence is a natural phenomenon because the genomic imprint created at each new birth is unique and may have the genetic weakness to cause diseases. Second principle is that the quality of living one’s life has the potential to cause illness or injury. Diabetes Mellitus arises largely from this twin causes.

6. If Diabetes Type 2 is a natural reality, how do we handle it. It cannot be eliminated because we cannot simply change or replace defective genes. At best we can prevent the early occurrence of the disease, reduce the morbidity and mortality associated with the expression of the disorder. Live the life that does not aggravate the genetically originated physiological and metabolic dysfunction.

7. Diabetes Mellitus is a genetic and life style driven complex metabolic disorders which is caused by insufficiency of insulin production or insulin dysfunction. Type 1 Diabetes ( insulin dependent ) is caused largely due to lack of functional beta cells in the pancreas and they need exogenous supply of insulin. Type 2 Diabetes Mellitus is unable to respond well to I insulin and can be treated with dietary changes, exercise, stress management and medicinal remedies.

8. One of natural healing postulations of the pathogenesis of Diabetes Mellitus especially Type 2 is that a person with deficient carbohydrate, lipid or protein metabolism has weak ability to repair free radical oxidative damage of cellular molecules, DNA, proteins and lipids leading to altered cellular functions. In other words these people do not have the full antioxidant power ability to destroy free radicals which are created in larger amounts in those whose blood glucose levels are post prandially relatively high. The gravity of oxidative damage in such people is more severe and there is every likelihood that many vital bio-chemicals including hormones such as insulin is damaged and rendered not effective in reducing blood glucose and other related metabolic disorders. The prolonged subtle oxidative damage in a compromised metabolic process leads to physiological complications.

9. FREE RADICALS – OXIDATIVE DAMAGE – GLYCATION Diabetic complications arise from the abnormalities produced in lipids and proteins from this free radical oxidative damage and glycation. The targets of these free radical driven oxidative damage include elastin, laminin, collagen and even insulin. These proteins are converted glycoproteins due to hyperglycemia. The changes of these proteins in tissues such as lens, vascular walls, and basement membranes are associated with the physiological and structural complications of diabetes such as cataracts, microangiopathy, atherosceloris , neuropathy, cardiomyopathy nephropathy etc. Advanced glycation end products are formed and accumulates in long lived molecules and generate abnormalities in cellular and tissue functions. Iincreased vascular permeability in micro and macrovascular structures results in endothelial dysfunction. AGE’s are also formed in nucleic acids and histones and may cause mutations and altered gene expression.

10. THE BIOMEDICAL ( ALLOPATHY ) MODEL REPLACEMENT OF GENETICALLY ENGINEERED HUMAN INSULIN FOR THOSE WHO CANNOT PRODUCE ENOUGH INSULIN OR THOSE WHOSE CELLS DO NOT RESPOND WELL TO INSULIN INHIBIT / REDUCE THE ABSORBTION OF CARBOHYDRATE AT THE GIT LEVEL EG : ARCABOSE ENHANCE GLUCOSE UPTAKE USING BIGUANIDES EG : METFORMIN STIMULATE BETA CELLS TO PRODUCE MORE INSULIN GLIBENCLAMIDE SENSITISE INSULIN RECEPTORS AVANDIA

11. HOW EFFECTIVE IS THE BIOMEDICAL MODEL THE MALAYSIAN OUTCOME SCENARIO IN MALAYSIA, CURRENT STATISTICS ON THE OUTCOME OF THE ALLOPATHY BIO-MEDICAL MODEL OF TREATMENT OF DIABETES MELLITUS TYPE 2 WITH MORE THAN 50,000 ALLOPATHY DOCTORS 335 HOSPITALS 30 MEDICAL COLLEGES WITH AN OPERATING BUDGET OF ABOUT RM 3 BILLION THE NUMBER OF DIABETICS IS STAGGERING ALMOST 3 MILLION PEOPLE IN A POPULATION OF 29 MILLION. ONLY 15% OF THE 3 MILLION PEOPLE HAVE HBAIC READINGS BELOW 6.5 THIS ISSUE IS NOT APPROPRIATELY ADDRESSED BY THE MOH. AT LEAST THERE SHOULD BE ABOUT 50% SUCCESS FOR A GOOD MEDICAL MODEL TO BE ACCEPTED.

12. WHY THIS FAILURE AND WHY NO PROPER ANSWER THE EPISTEMOLOGY USED IN THE BIO-MEDICAL MODEL IS BASICALLY PHYSICAL AND DOES NOT COVER ALL ASPECTS AND FACTORS THAT CREATES OR AGGRAVATES THE DISEASE. THE NATURE OF THE HUMAN BEING HAS THREE INTER-RELATED ASPECTS OR COMPONENTS ANIMATING ENERGY, MIND ( ONTOLOGICAL) AND BODY ( PHYSICAL ) BY IGNORING THE ONTOLOGICAL AND HOLISTIC ASPECTS THE CLINICAL POSITIVE OUTCOME WILL BE COMPROMISED AND ONLY PARTIAL SOLUTION IS ACHIEVED. THE IATROGENIC PROBLEMS ASSOCIATED WITH CHEMICAL THERAPY IS NOT ADDRESSED SUFFICIENTLY.

13. THE HOLISTIC NATURAL HEALTHCARE MODEL TAKES INTO CONSIDERATION THE ENERGY, MIND AND BODY ASPECTS. THE ENERGY-MIND COMPONENTS HAS TO BE TRAINED AND CONDITIONED TO REGULATE THE EIGHT CRITICAL FACTORS THAT AFFECT HEALTH AND THE GLYCEMIC STATE OF THE PERSON. THE EIGHT MAJOR CRITCAL FACTORS THAT AFFECT HEALTH AND BLOOD GLUCOSE LEVELS : GENOMIC STATUS DIET AND NUTRITION PHYSICAL ACTIVITY AND EXECRCISE PHYSICAL, MENTAL AND EMOTIONAL STRESS LIFE STYLE ENVIRONMENT ( BOTH PHYSICAL AND NON-PHYSICAL) AGE DRUG TOXICITY / OXIDATIVE DAMAGE

14. THE NATURAL HOLISTIC MODEL FOR DIABETES MELLITUS TYPE2 REGULATION AND CONDITIONING OF THE MIND WITH A PROACTIVE FORECARING CONTINUOUS APPROACH WITH MODERN MEDITATION AND YOGIC EXERCISE. ASSUMPTION THAT EVERYONE HAS THE POTENTIAL TO DEVELOP DIABETES MELLITUS AND FORECARING PROACTIVE SUSTAINING KNOWLEDGE EMPOWERMENT ARE INSTILLED INTO ALL PEOPLE FOR WELLNESS AND ILLNESS. ENSURE THAT THE BODY IS OPTIMALLY NOURISHED WITH FULL SPECTRUM, BOTH MACRO AND MICRO – NUTRITION WHICH WILL COVER THE CONTINUOUS NEED TO OPTIMISE THE VITAL BIOCHEMICAL BALANCE IN THE BODY TO ENSURE THAT THE BODY IS PROETCTED FROM THE OXIDATIVE AND OTHER DAMAGE.

15. TO ENSURE THAT THE BODY, DESPITE GENETIC PREDISPOSITION TO DIABETES AND OTHER DISEASES ARE GIVEN NUTRITIONAL PRODUCTS WHICH HAS THE FULL SPECTRUM OF NUTRITION AND VITAL BIO-ACTIVE SUBSTANCES. THE BODY HAS THOUSANDS OF BIO-CHEMICALS WORKING IN A COMPOSITE MANNER, IN UNISON WITH EACH OTHER TO MAINTAIN GOOD PHYSIOLOGY AND METABOLISM. BASED ON THIS POSTULATE, PRODUCTS FOR PREVENTION OF EARLY APPEARANCE OF THE DISEASE MUST CONTAIN THE FULL SPECTRUM OF NUTRIENTS WITH AS MUCH ANTIOXIDANTS AS POSSIBLE AND ALL BIO-ACTIVE SUBSTANCES TO OPTIMSE SUSTAINABLE HIGH EFFICIENT PHYSIOLOGY.

16. RANGE AND CATEGORIES OF MEDICINAL PRODUCTS AND THEIR SAFETY AND EFFICACY STATUS NUTRITIONAL PRODUCTS HARDLY ANY IATROGENICITY MAXIMUM SAFETY MODERATE SAFETY MINIMAL IATROGENICITY HERBAL PRODUCTS HIGH IATROGENICITY MINIMAL SAFETY CHEMICAL DRUGS

17. LIST OF COMMON INDIAN HERBAL PRODUCTS USED FOR DIABETES 1.ACACIA ARABICA ( BABHUL) ACTS AS A SECRETAGOUGE TO RELEASE INSULIN 2. AEGLE MARMELOS ( BENGAL QUINCE) EXHIBITS HYPOGLYCEMIC ACTIVITY AND PREVENTS PEAK RISE IN BLOOD SUGAR IN GTT. 3. ALOE VERA AND ALOE BARBADENISIS STIMULATION OF SYNTHESIS AND RELEASE OF INSULIN FROM PANCREATIC BETA CELLS 4.AZADIRACHTA INDICA ( NEEM ) INCREASE OF GLUCOSE UPTAKE AND GLYCOGEN DEPOSITION 5 CASALPINA BONDUCELLA REDUCES BLOOD SUGAR THROUGH GLUCONEOGENSIS 6. CAPPARIS DECIDA REDUCES OXIDATIVE STRESS AND REDUCES DIABETIC COMPLICATIONS

18. 7 . COCCINIA INDICA REDUCES ENZYMATIC DAMAGE DUE TO DIABETES 8. EUGENIA JAMBOLANA ( INDIAN GOOSEBERRY) INHIBITS INSULINASE ACTIVITY 9. MANGIFERA INDICA INTESTINAL REDUCTION OF THE ABSORPTION OF GLUCOSE 10. OCIMUM SANCTUM (HOLY BASIL) SIGNIIFICANT REDUCTION IN BLOOD SUGAR LEVEL IN BOTH NORMAL AND ALLOXAN INDUCED DIABETIC RATS 11. PHYLLANTHUSS AMARUS REDUCED BLOOD SUGAR IN ALLOXANIZED DIABETIC RATS 12. PTEROCARPUS MARSUPIUM BETA CELL REGRANULATION, INSULINOGENIC AND COVERSION OF PRO – INSULIN TO INSULIN IN VITRO STUDIES.

19. 14. TINOSPORA CORDIFOLIA ANTI-HYPERGLYCEMIC IN ANIMAL MODELS USED IN THE TREATMENT OF DIABETES IN AYURVEDIC MEDICINE • HERBAL DRUG FORMULATIONS • DIABECON • REPORTED TO INCREASE PERIPHERAL UTILIZATION • OF GLUCOSE AND REDUCES OXIDATIVE STRESS • 2. EPIINSULIN • INCREASES INSULIN RELEASE, REDUCES DIABETIC • COMPLICATIONS • 3.DIACARE BY ADMARK HERBALS • USED IN THE TREATMENT OF DIABETES 1 & 2 • 4. DIABETES DAILY CARE BY NATURES HEALTH SUPPLY • IMPROVES SUGAR METABOLISM • 5. DIABETA BY AYURVEDIC CURE • ANTIDIABETIC FORTIFIED WITH IMMUNEMODULATORS

20. IN MALAYSIA LOCAL HERBAL PRODUCTS HAVE HARDLY ANY CLINICALLY STUDIES IN REAL LIFE SITUATION. HOWEVER HIGHLY ACTIVE MICRO-NUTRIENT FORMULATIONS USING COMPOSITE EDIBLE SEEDS HAVE BEEN DEVELOPED AT THE DEPARTMENT OF RESEARCH AND STUDY AK PHARMACY AND NATUROPATHY CENTRE SINCE 2000. SPECIFICALLY TWO COMPOSITE PRODUCTS ( NOT EXTRACTS ) HAVE BEEN DEVELOPED ONE IS BRANDED AS MANNA PLUS WHICH CONTAINS 373 SUBSTANCES WITH ANTI-OXIDANT PROPERTIES AND THE OTHER IS MAS PAHIT WHICH IS USED IN COMBINATION WITH MANNA PLUS TO REDUCE HYPERGLYCEMIA. MORE THAN 5000 PATIENTS HAVE USED THIS TWIN FORMULA AND THEIR ANTI-HYPERGLYCEMIC EFFECTS HAVE BEEN RECORDED.

21. THE PROTECTIVE EFFECT FROM OXIDATIVE DAMAGE HAS BEEN WELL DOCUMENTED USING REALTIME OUTCOME- DRIVEN STUDIES. REFER TO www amriasia.org FOR CASE STUDY REPORTS

22. Mas Ayu Pahit Number Of Known Bioactive Chemical s : 891 Number Of Reported Nutritional And Medicinal Activities : 1879

23. The Ultimate Biochemical Balance Mas Ayu Manna Plus Number Of Known Bioactive Chemical : 14000 Number Of Reported Nutritional And Medicinal Activities : 3870

24. The Actual Number of BioActive Principles In Manna Plus ( Without Overlaps )

25. Posology of Highly Active Micro-Nutrient Formulae for Diabetes Prevention and Management Prevention of Diabetes starts with conception of Life Healthy diet for mother and fetus Minimal Physical and Mental Stress Full Spectrum Diet Rest and Recreation Healthy Life Style Products are taken which can ensure minimal oxidative damage throughout life. Manna Plus 101 Pahit 101 For Diabetes Mana Plus 111 or 222 Pahit 111 or 222 or even 333 For glycemic control and prevention of diabetic complication and aggravation of the disease .

26. Observed Real-Time Outcome using Highly Active Micro-Nutrients alone or integrated with allopathic drugs with more than 3000 patients With mild or moderate hyperglycemia Highly Active Micro-Nutrients alone with proper Diet and Life Style can control Diabetes and reduce morbidity. Case Studies available at www amriasi.org With severe Diabetes Mellitus Highly Active Micro-Nutrient Formula synergises and potentiates hypoglycemic activity and keep blood sugar under control. HBAIC below 7.0 In cases of insulin resistance , where insulin is rendered inactive, through oxidative damage blood glucose improves through high antioxiddant and bio-chemical effects provided healthy life style is practiced. Ref: www amriasia.org.

27. Disruption of Energy Balance & Build Up of Glucose in the Body sun • Cellular uptake and intracellular breakdown of glucose to CO2, H20 & energy (ATP to ADP & energy) which is used to power reactions in the cells. E.g The production of the glucose regulating hormones insulin and glucagon in the cells of the pancreas. Oversupply or undersupply of energy will disrupt the energy balance and disturb the optimum production of insulin and glucagon. • Excessive glucose is converted to adipose fats. • Glucose is also converted to glycogen and stored in the liver. Sun Glucose transported by blood to the cells Solar Energy 93 million miles away Plant Photosynthesis CO2 & H20 & Cholorophyll Eaten & Digested to Glucose in the Gastro Intestinal System Carbohydrates e.g. Rice, Wheat, Tubers etc Glucose (Energy Molecule) • DIABETES MELLITUS • 1. Disruption of the energy balance, oversupply or undersupply of energy to the cells beyond its ability to cope. • Glycation and Oxidative damage to proteins and other vital bio-active chemicals in the body , causes physiological and metabolic dysfunction.

28. OVER CONCENTRATION OF GLUCOSE IN THE BLOOD WHY- HOW –WHEN ??? CELLULAR UPTAKE OF GLUCOSE DEPENDS ON THE INTENSITY OF INTRACELLULAR ACTIVITY MENTAL AND PHYSICAL STRESS CELL NUMBER OF ACTIVE CELLS ESPECIALLY MUSCULAR CELLS MUSCLE MASS REDUCES WITH AGE AND LACK OF PHYSICAL ACTIVITY GENETIC PREDISPOSITION OXIDATIVE DAMAGE TO DNA AND ORGANS DUE TO FREE RADICALS. OVER EATING POOR QUALITY NUTRITION

29. MAJOR CAUSES OF DIABETES CREATING OUR OWN SUGAR ON A LARGE COMMERCIAL SCALE CREATING DRINKS WITH HIGH CONCENTRATION OF SUGAR AND CHEMICALS. CANNED DRINKS COCA-COLA, PEPSI ETC. SWEETENED TEA AND COFFEE SYRUPS AND ARTIFICIAL FRUIT JUICES OVEREATING HIGH GLYCEMIC FOOD, OVER BURDENING THE SYSTEM MENTAL AND PHYSICAL STRESS AND OXIDATIVE STRESS

30. BIOENERGENOMICS THE NATURAL HEALTHCARE MODEL OF GLUCOSE IMBALANCE IN THE HUMAN LIFE FORM INCORPORATING THE PROCESS NATURE OF THE HUMAN BEING BASED ON THE COSMIC QUANTUM THEORY AND THE THEORY OF RELATIVITY THE PROCESS THEORY OF NATURAL HEALING THE COSMIC ECOLOGICAL INTER-RELATEDNESS CRITICAL FATORS OF THE ENERGY –BALANCE

31. UNDERSTANDING THE COSMIC NATURE OF THE HUMAN BEING AND DISEASES. THE CONTINUUM OF HUMAN EVOLUTION THE ACUMULATED HUMAN INTELLIGENCE NATURE’S ADAPTATION THROUGH RANDOM GENETIC MIXING , SELECTION AND ELIMINATION NATURES PRESERVES THE STRONG AND ELIMINATES THE WEAK. IN THE EVOLUTIONARY PROCESS BOTH BODILY AND INFECIVE DISEASES INDICATES A WEAK OR DAMAGED LIFE FORM . THEY ARE ELIMINATED THROUGH DISEASES OR DESTRUCTION HIGHER AND HIGHER LEVEL OF ACCUMULATED HUMAN INTELLIGENCE THE HUMAN BEING THE EVOLUTIONARY PROCESS

32. THE NATURE OF THE HUMAN BODY ENERGY HUMAN BEING IS A PROCESS MIND IT IS ALWAYS CHANGING LIKE THE WATERFALL BODY

33. WE ARE A FUNCTION OF NATURE’S PROGRESSIVE CREATIVE WORK OUR CREATED STATUS IS NATURE’S RANDOM EXPERIMENT BETTER CREATION DEFECTIVE CREATION NEW CREATION NEW CREATION WORSE CREATION WEAKER CREATION SUPER CREATION DO WE KNOW WHERE WE STAND ?

34. WE MUST FIRST UNDERSTAND THE NATURE OF HUMAN LIFE IN ORDER TO DEVELOP THE TRUE SCIENCE OF HEALTH AND MEDICINE . THE HUMAN LIFE FORM IS AN INTEGRAL PART OF THE COSMOS AND IT IS A INTERACTIVE PROCESS WHICH INVOLVES ENERGY, MIND AND BODY THE HUMAN LIFE FORM IS A PROGRESSIVE EXPANDING PHENOMENON WHICH IMPELLED BY THE CREATIVE FORCES OF COSMIC INTELLIGENCE. CHANGING ALL THE TIME

35. COSMIC ECOLOGICAL INTER-RELATEDNESS • LARGELY CONFINED TO PHYSICAL BODY PARADGIM IGNORING THE ROLE OF MIND AND ENERGY IN HUMAN HEALTH TREATMENT (MEDICINE AND SURGERY) EPISTOMOLGY BASED ON CARTESIAN-NEWTONIAN MECHANISTIC -PHYSICAL WRLDVIEW. PHYSICAL SCIENTIFIC METHOD AS THE BASIS OF INQUIRY DEPENDENT LARGELY ON PHYSICAL , QUANTIFIABLE ,MEASURABLE PARAMETERS FOR STUDY, RESEARCH AND UNDERSTANIDING BODY IS TREATED LARGELY AS A MACHINE REDUCTIONIST APPROACH AND MOLECULAR THEORY OF DISEASE CAUSATION. THE COSMIC ECOLOGICAL INTERRELATEDNESS SUN 93 MILLION MILES SOLAR /COSMIC ENERGY HEALTHCARE PRESERVATION OF HEALTH PREVENTION OF DISEASES EARTH ENERGY MIND BODY Earth BODY INVISIBLE & NON PHYSICAL PHYSICAL /VISIBLE LIFE FORMS INCLUDING HUMAN LIFE FORM HUMAN LIFE FORM TRUE HEALTHCARE AND MEDICINE MUST COVER ALL THREE AREAS OF HUMAN LIFE

36. MAJOR CRITICAL FACTORS THAT AFFECT THE LEVEL OF GLUCOSE IN BLOOD GENETTIC HEREDITARY FACTOR LIVE WITHIN YOUR LIMITS CONSUME WHAT YOU NEED DIET AND NUTRITION MAINTAIN YOUR EFFICIENCY PHYSICAL ACTIVITY AND EXERCISE ANDREST DO NO HARM TO YOUR BODY LIFE STYLE AND HABITS DO NOT BURDEN YOUR BODY AND LIFE MENTAL AND PHYSICAL STRESS

37. WORLD OF SPICES, SEEDS & CEREALS Barley Seeds Turmeric Ginger Neem Leaves Cinnamon Wheat Seeds Black Cumin Onions A tree in a seed All Kind of Seeds Garlic All Kind of Seeds Coffee Seed Sesame Seeds Fennel Cumin

39. Thank You