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Cancer Research in NEC Labs America’s Machine Learning Dept.
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  1. Cancer Researchin NEC Labs America’sMachine Learning Dept. Matt Miller Research Staff Member NEC Labs America

  2. Modern Tools for Oncology • Detailed diagnostics • Targeted therapies • Methods of mapping diagnostic results to therapies (“personalized medicine”) • Methods of testing these tools

  3. How Machine Learning Fits In • Detailed diagnostics • Pattern recognition • Targeted therapies • Machine-assisted drug design • Methods of mapping diagnostic results to therapies (“personalized medicine”) • Cocktail design • Methods of testing these tools • Statistical learning theory

  4. How Machine Learning Fits In • Detailed diagnostics • Pattern recognition • Targeted therapies • Machine-assisted drug design • Methods of mapping diagnostic results to therapies (“personalized medicine”) • Cocktail design • Methods of testing these tools • Statistical learning theory

  5. NEC’s Digital Pathology System • Given a digitized pathology image, determine whether benign or malignant. • Initial application: double-check diagnoses of human pathologists. • First implemented for gastric cancer. • Current development work: • Colon cancer • Breast cancer • Prostrate cancer

  6. NEC’s Digital Pathology System ROI’s Image of whole tissue Lo-res analysis (decision-tree like method) Malignant/ Benign Hi-res analysis (SVM’s, CNN’s)

  7. NEC’s Digital Pathology System • Gastric system tested on 1905 biopsies. • Compared against diagnoses by three human pathologists. • 100 malignant cases • Results: • 227 / 1805 (12.6%) false positives • 1 / 100 false negative

  8. Cocktail Design • Assume there is an unknown function • Find a function Such that is good

  9. Cocktail Design: We Have … • Some theoretical results due to Vapnik. • Proposal for an algorithm. • Methods for handling real-world problems • Limits on what machine may try while learning. • Paucity of real cases. • No data to work on.

  10. Vladimir Vapnik Léon Bottou Eric Cosatto Christopher Malon Matt Miller NEC ML People Here Today