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Regulation of Fe-S Cluster Biogenesis in Cyanobacteria Under Oxidative Stress

This study explores the SufC and SufE model for regulatory mechanisms involved in iron-sulfur (Fe-S) cluster biogenesis in cyanobacteria, particularly under oxidative stress conditions. We focus on key components such as sufB, sufC, sufD, sufS, sufR, and Nfu, investigating their roles in maintaining redox poise and Fe homeostasis. The feedback regulation of these proteins is crucial for understanding the balance of iron within the cell, emphasizing the importance of IscA and the function of SufA in Fe-S protein synthesis and stability.

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Regulation of Fe-S Cluster Biogenesis in Cyanobacteria Under Oxidative Stress

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  1. SufC Fe/S Fe/S Model for regulation of Fe/S cluster biogenesis in cyanobacteria Oxidative stress Redox poise sufB sufC sufD sufS sufE sufR SH SH SH SH SufA SufA Fe/S SufS SufD SufB SH SH SH SH SufR SufR Nfu SufE Scaffold? Feedback regulation So or S2- Fe2+ Nfu IscA IscA Fe/S Fe-S protein apoprotein Fe homeostasis

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