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NCEPOD SEPSIS STUDY. NCEPOD. To review medical and surgical practice and to make recommendations to improve the quality of the delivery of care.

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To review medical and surgical practice and to make recommendations to improve the quality of the delivery of care.

By undertaking confidential surveys covering many different aspects of medical care and making recommendations for clinicians and management to implement.

Sepsis study aim
SEPSIS study: Aim

“To identify and explore avoidable and remediable factors in the process of care for patients with known and suspected sepsis”

Sepsis study objectives
SEPSIS study: Objectives

  • To examine organisational structures, processes, protocols and care pathways for sepsis recognition and management in hospitals from admission through to discharge or death

  • To identify avoidable and remediable factors in the management of the care for a sample of adult patients with sepsis, throughout the patient pathway from presentation to primary care (if applicable) throughout secondary care to discharge or death

Key areas
Key areas

  • Recognition of sepsis

  • Evaluation of systems in place to facilitate recognition/ escalation/ treatment

  • Management of infection

  • MDT approach

  • Communication

  • End of life care

Case identification prospective
Case Identification-prospective

  • Prospective identification

  • Study contacts set up in critical care (ICU/HDU) and on critical care outreach team (CCOT)

  • Study contacts identify cases in ICU/HDU and seen by CCOT during study period: 6th-20th May 2014

  • Study contacts complete case ID spreadsheet and return to NCEPOD

Study population
Study population

  • Adult patients (≥16 years old) that are seen by the critical care outreach team (or equivalent) or that are admitted directly to critical care with sepsis during the study period:

    6th - 20th May 2014


  • Immunosuppressed neutropaenic patients on chemotherapy, immunosuppressant drugs or transplant programmes.

  • Pregnant women up to 6 weeks post-partum (covered by MBRRACE-UK sepsis study)

  • Patients on end of life care pathway at time of diagnosis or consultant-led decision made not to escalate (prior to entry into the study)

  • Patients that develop sepsis after 48 hours on ICU/HDU

  • Children <16 years

Data collection retrospective
Data collection- retrospective

  • Retrospective data collected on patients identified

    • including consultant details, discharge/30 day outcome information and ICD10 coding

  • Clinician questionnaire – completed by named consultant at time of diagnosis

    - collect data on acute care up to 30 days after entry into the study

  • Case note extracts

    • admission to discharge/30 days after entry into the study.

  • Organisational questionnaire

    • collect data on organisation of care

    • To be sent to all hospitals that deal with adult patients with sepsis

Advisor case review
Advisor case review

  • Multidisciplinary group of Advisors will be recruited to review case notes and questionnaires and rate the quality of care

  • Advisors will be recruited from a number of specialties including: emergency medicine, acute medicine, critical care outreach, general medicine, general surgery, intensive care.


  • Findings will be published in Autumn 2015

  • Please visit the NCEPOD website or call 020 7251 9060 for more information

    Thank you for your support!