Genomics, Proteomics, and Bioinformatics. Biology 224 Instructor: Tom Peavy January 29, 2008. What is bioinformatics?. Interface of biology and computers Analysis of genomes, genes, mRNA and proteins using computer algorithms and computer databases. What is Genomics?.
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Instructor: Tom Peavy
January 29, 2008
What is Proteomics?
What is the Transcriptome?
 Precise models of where and when transcription
will occur in a genome (initiation and termination)
 Precise, predictive models of alternative RNA splicing
 Precise models of biological pathways;
ability to predict cellular responses to external stimuli
 Determining protein:DNA, protein:RNA, protein:protein
 Accurate ab initio protein structure prediction
 Rational design of small molecule inhibitors of proteins
 Mechanistic understanding of protein evolution
 Mechanistic understanding of speciation
 Development of effective gene ontologies:
systematic ways to describe gene and protein function
 Education: development of bioinformatics curricula
Source: Ewan Birney,
Chris Burge, Jim Fickett
We will study it in a variety of contexts including
Base pairs of DNA (billions)
>40b base pairs
(NCBI, EMBL, & DDBJ)
The growth of GenBank. The blue area shows the total number of bases including those from whole genome shotgun sequencing projects (WGS). The checkered area shows only the non-WGS portion. With release 149, the number of WGS bases exceeded the number of bases in the traditional GenBank divisions.
that integrates NCBI databases
Are made to Eukaryotic mRNAs?
-used to clone large pieces of DNA
Orthologous vs Paralogous Genes