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Drugs which interfere with the synthesis of NA (Methyldopa) PowerPoint Presentation
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Drugs which interfere with the synthesis of NA (Methyldopa) - PowerPoint PPT Presentation


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Drugs which interfere with the synthesis of NA (Methyldopa) Methyldopa is a dopa decarboxylase competitive inhibitor  prevention of the conversion of dopa to dopamine  inhibition of the biosynthesis of NA

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slide1

Drugs which interfere with the synthesis of NA (Methyldopa)

  • Methyldopa is a dopadecarboxylase competitive inhibitor  prevention of the conversion of dopa to dopamine  inhibition of the biosynthesis of NA
  • Methyldopa is metabolized to α-methyl NA which is stored in the sympathetic nerve endings displacement of NA and acts as a false transmitter
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α-Methyl NA stimulates presynapticα2-receptors in the brain  inhibition of NA release from adrenergic neurons &  sympathetic tone  PVR  BP

  • It does not decrease COP or blood flow to vital organs specially the kidney
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Therapeutic Uses:

  • Hypertension
  • It is the drug of choice in the treatment of hypertension during pregnancy)
  • Treatment of hypertensive patients with renal insufficiency
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Side effects:

  • Postural hypotension
  • Central sedative action
  • Contraindications:
  • Pheochromocytoma
  • Active liver diseases