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Drugs which interfere with the synthesis of NA (Methyldopa)

Drugs which interfere with the synthesis of NA (Methyldopa) Methyldopa is a dopa decarboxylase competitive inhibitor  prevention of the conversion of dopa to dopamine  inhibition of the biosynthesis of NA

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Drugs which interfere with the synthesis of NA (Methyldopa)

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  1. Drugs which interfere with the synthesis of NA (Methyldopa) • Methyldopa is a dopadecarboxylase competitive inhibitor  prevention of the conversion of dopa to dopamine  inhibition of the biosynthesis of NA • Methyldopa is metabolized to α-methyl NA which is stored in the sympathetic nerve endings displacement of NA and acts as a false transmitter

  2. α-Methyl NA stimulates presynapticα2-receptors in the brain  inhibition of NA release from adrenergic neurons &  sympathetic tone  PVR  BP • It does not decrease COP or blood flow to vital organs specially the kidney

  3. Therapeutic Uses: • Hypertension • It is the drug of choice in the treatment of hypertension during pregnancy) • Treatment of hypertensive patients with renal insufficiency

  4. Side effects: • Postural hypotension • Central sedative action • Contraindications: • Pheochromocytoma • Active liver diseases

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