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MEDS 371, Systems Neuroscience Pain System Dr. D. O. Kim. dorsal horn of the spinal cord. CGRP: calcitonin gene related peptide; 5-HT: serotonin. capsaicin. VR-1: vanilloid receptor type 1. C. D. Kandel Fig. 24-4. synapse of a C-fiber (“C”) on the dendrite (“D”)

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slide1

MEDS 371, Systems Neuroscience

Pain System

Dr. D. O. Kim

slide2

dorsal horn of

the spinal cord

slide4

CGRP:

calcitonin gene

related peptide;

5-HT: serotonin

slide5

capsaicin

VR-1: vanilloid receptor type 1

slide6

C

D

Kandel Fig. 24-4

synapse of a C-fiber (“C”) on the dendrite (“D”)

of a dorsal-horn neuron.

small vesicles: glutamate;

large vesicles: neuropeptides.

slide7

discriminative

pain pathways

(except face/head)

anterolateral

system

(ALS);

spinothalamic

tract

slide8

spinal-cord hemisection

Brown-Sequard’s syndrome

section at lumbar spinal cord

Purves

slide9

trigem

gang

discriminative

pain pathways:

face/head

trigemino-

thalamic

tract

slide10

trigeminal pathways

somatosensory

cortex

principal trigem.

sensory

nucleus

trigemino-

thalamic

tract

pons

trigeminal

ganglion

spinal trigem.

tract &

nucleus

medulla

Haines

Fig 8-9

slide11

affect:

n. the conscious subjective aspect of an emotion

apart from bodily changes.

[Webster’s New Collegiate Dictionary]

two distinct aspects of the experience of pain
Two distinct aspects of the experience of pain

thalamic nuclei:

midline; anterior;

mediodorsal

modified from Purves Fig 10-5

slide13

thamaic nuclei

Netter

CM: centromedian; LD: laterodorsal; LP: lateroposterior;

MD: mediodorsal; VA: ventral anterior; VL: ventral lateral;

VPL: ventral posterolateral; VPM: ventral posteromedial

slide14

thalamus

cingulate

cortex

hypothalamus

Purves Fig. A-12

slide15

insula

Purves Fig. A-10

slide16

affective

pain pathways;

unpleasant quality

of pain

slide17

endogenous opioids:

enkephalin; dynorphin; endorphin;

in

midbrain periaqueductal gray

rost. vent. medulla

spinal cord

slide18

descending

control of

pain pathways

hypothalamus

Kandel

Fig 24-11

slide20

descending

control of

pain pathways

Purves Fig 10-8B

slide21

placebo effect

a physiological response following the

administration of an inert "remedy"

slide22

referred pain

Kandel Fig. 24-5

Purves

slide23

Methods for Rainville et al., 1997

To immerse a hand in painfully hot water

(47 °C) for 75 sec;

Hypnosis: high or low unpleasantness

slide24

Activation of

anterior cingulate

cortex (ACC) by

pain

PET imaging of

human brains

Rainville et al 1997