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Transdisciplinary Research in Reproductive Medicine

Transdisciplinary Research in Reproductive Medicine. Jeff Nisker MD PhD FRCSC Schulich School of Medicine & Dentistry University of Western Ontario. Transdisciplinary Research. “multi-” “more than one” “trans-” “across”

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Transdisciplinary Research in Reproductive Medicine

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  1. Transdisciplinary Research in Reproductive Medicine Jeff Nisker MD PhD FRCSC Schulich School of Medicine & Dentistry University of Western Ontario

  2. Transdisciplinary Research “multi-” “more than one” “trans-” “across” • shift from unidisciplinary to interdisciplinary approaches, and from individualized projects toward collaborative team (JT Klien 1996, D Stokols 1996, National Academy of Sciences 2004) • growing interest and investment in promoting interdisciplinary collaboration is reflected in several large-scale research initiatives, including the establishment of the MacArthur Foundation (RL Kahn 1993)

  3. CIHR’s Pillars of Health Research • biomedical science • clinical science • health systems and services • social, cultural, environmental and other aspects that effect the health of populations Projects should consider multiple pillars

  4. Mixed Methods Research 1. laboratory methods 2. clinical science methods a) RCT b) cohort c) n of 1 3. social science methods a) survey research b) qualitative research (i) interviews (ii) focus groups (iii) audience discussions 4. humanities methods

  5. Transdisciplinary Research Cube policy research biomedical science  clinical practice social science

  6. Problem of High Order Multiple Pregnancy in Canada • SOGC Initiative (Barrett, Bocking et al JOGC 2000) • CIHR Conference (2002)

  7. “Toward Single-Embryo Transfer” – CIHR (2004)

  8. Co-PIs on projects

  9. “Towards Single-Embryo Transfer”

  10. Cross-pollination among Project • preparing grant • REB approval • informal meeting • formal meetings • papers

  11. Project 8 - Ethical Issues: Team Members Jeff Nisker physician, scientist MD-patient relationship, hESC research, health policy Francoise Baylis philosopher health policy, eligibility of embryos for donation to hESC research Carolyn McLeod philosopher reproductive rights Samantha Brennan philosopher children’s rights Roxanne Mykitiuk legal scholar legal issues in ARGTs and rights of disabled people.

  12. Project 8 – Ethical Issues: Research Areas • ethical and legal concepts of a “healthy” embryo • informed choice regarding fertility conservation in children with cancer • ethical and legal considerations of embryo “donation” a. to hESC research b. to other patients • ethical and legal considerations of oocyte “donation” • health policy development in ARGTs • stem cell research • other ethical and legal issues of ARGTs

  13. Project 8 – Publications •  Nisker JA, White AD “The CMA Code of Ethics and the donation of fresh embryos for stem cell research”. CMAJ Sept. 2005;173(6):621-2.  • Ram N. Regulating Consent to Human Embryo Research: A Critique of Health Canada’s Proposal. Health Law Review 2005; 14(2): 19-27. •  Baylis F. Embryological Viability. American Journal of Bioethics 2005; 5(6): 17-18. •  McLeod C. “’Embryo Autonomy? What about the Autonomy of Infertility Patients?” American Journal of Bioethics 5(6), 2005: 25-26. •  McLeod C. Letter to editor of the Hastings Center Report on Rebecca Kukla’s “Conscientious Autonomy: Displacing Decisions in Health Care” (HCR 35(2), 2005: 34-44), HCR 35(5), 2005: 5. • McLeod C, Baylis F. Feminists on the Inalienability of Human Embryos Hypatia 2006; 21(1): 1-14. • Nisker J “Compassion as Well as Clarity”, J Obstet Gynaecol Can ” [Let] Feb 2006; 28(2): 121 • Nisker J, Baylis F, and McLeod C. “Preserving the Reproductive Capacity of Girls and Young Adolescent Women with Cancer: Informed Choice,” Cancer, in press. • Daniels K, Feyles V, Nisker K, et al. “Semen donation: Implications of Canada’s Assisted Human Reproduction Act, 2004 on recipients, donors, health professionals, and institutions” J Obstet Gynaecol Can in press 2006. • Ram N. Britain's New Preimplantation Tissue-Typing Policy: An Ethical Defense. Journal of Medical Ethics in press. • McLeod C. “For Dignity or Money: Feminists on the Commodification of Women’s Reproductive Labour” (11,063 words), Oxford Handbook of Bioethics, in press. • White A, Nisker J, Tekpetey F, Feyles V “Donation of Embryos to Stem Cell Research in Canada: A Free and Informed Choice Process”, in preparation. • Mykitiuk R, Nisker JA, “Lenses and ‘Healthy’ Embryos”, in preparation.

  14. Structural and Functional Annotation of the Human Genome for Disease: R Hegele and M Shier Theme 5 (Nisker): Ethical, legal, and societal implications of research into monogenic-related heart disease and breast cancer Sub-themes:

  15. Transdisciplinary Graduate Program in Health Sciences, UWO • begins September 2006 • MHSc and PhD in Health Science • physicians and medical students, law students and lawyers, as well traditional health science professions (nursing, rehab, PT, OT, SP) and students having completed other undergraduate degree programs

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