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Requirements for and Challenges associated with BSL4 laboratories. Dr Greg Smith Microbiological Security Manager Australian Animal Health Laboratory Geelong, Victoria . How many are needed?. Australia – population of 22.5 million 4x BSL4 Laboratories

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requirements for and challenges associated with bsl4 laboratories

Requirements for and Challenges associated with BSL4 laboratories

Dr Greg Smith

Microbiological Security Manager

Australian Animal Health Laboratory

Geelong, Victoria

how many are needed
How many are needed?
  • Australia – population of 22.5 million
  • 4x BSL4 Laboratories
  • 1 x National Animal High Containment Lab (AAHL)
  • 3x State Public Health PC4 labs (Brisbane, Sydney and Melbourne)
  • Expansion of AAHL new PC4 lab 320 m2

CSIRO .Greg Smith Istanbul July 2011

australian animal health lab
Australian Animal Health Lab
  • Opened in 1985
  • 26 years old
  • $200M to build
  • Replace $650-700
  • 35 hectares
  • Building 2 Ha
  • 6 Floors
  • 65,000 m2
  • 15,000m2 ‘lab’

Lab

  • BSL2 = 2600 m2
  • BSL3 = 2900 m2
  • BSL4 = 100 m2 (400m2)

Animal Facility

  • BSL3 = 955 m2
  • BSL4 = 127m2
construction and maintenance costs
Construction and Maintenance costs
  • 60 F/T Engineering staff
  • 10 Microbiological Security Staff ($1M annually)
  • $6.8M annual maintenance & running cost
  • $15M/yr depreciation
  • $25Mengineering upgrade just completed focused on control and monitoring

Server Rm South

5

Server Rm North

Machine Hall

L5 Plant Room

Admin

CMS

ESB CMS

5

5

3

4

3

2

1

construction and maintenance costs1
Construction and Maintenance costs
  • Changing standards will require additional & significant investment
  • 30 autoclaves to be refurbished or replaced ($5M-$15M)
  • Laboratory has operated continuously since opening
  • Science mission requires continuous operation during refurbishment
  • Construction costs while operating $$$$
biosecurity
Biosecurity
  • Perimeter fence, box within box, infrared cameras
  • Dual access controls & Cyberlocks
  • Critical Infrastructure protection branch
  • All AAHL staff with security access are ASIO cleared

CWA 15793

CSIRO.Greg Smith Istanbul July 2011

environmental issues
Environmental issues
  • Originally built to provided diagnostic capacity and vaccine production facilities for FMDV
  • FMDV has never been introduced to the lab
  • Local council regulations prevent residents keeping cloven hoofed animals within 5 kilometres.
  • Staff not permitted to live on farm
  • 7 day exclusion for all staff and visitors

Greg Smith Istanbul July 2011

training
Training
  • Structured competency based training
  • Must first complete all BSL3 training and be signed off as competent to work at BSL3/4
  • Dedicated training lab
  • All routine and emergency procedures in training lab
  • Supervisors sign off BSL4 competency

CSIRO Greg Smith Istanbul July 2011.

strategies to manage infected individuals
Strategies to manage infected individuals
  • Medical Advisory Committee
    • State Chief Health Officer
    • State Chief Veterinary Officer
    • Local General Practitioner
    • Infectious Disease Physician
  • All incidents referred to MAC
  • Home quarantine or admission to ID ward

CSIRO. Greg Smith Istanbul July 2011

community relations
Community Relations
  • Dedicated Media Officer
  • Active engagement of public including schools
  • Tours for key State and Federal politicians
  • Facilitate media coverage (60 minutes, Catalyst etc.)
  • Helps to have a long record >25 yrs of safe operation within the community

CSIRO. Greg Smith Istanbul July 2011

maximising the investment reducing the risk
Maximising the investment; reducing the risk
  • $10M to convert existing facility to specialised BSL3 and BSL4 lab space
  • Available to scientists across Australia and globally
  • Government, academic or commercial clients
  • Existing & proven systems and experienced staff

CSIRO Greg Smith Istanbul July 2011.

slide12

Thanks for your attention!

CSIRO.Greg Smith Istanbul July 2011