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Fig 2: Da Devare SG, J Med Virol 2007. Fig 2: Da Devare SG, J Med Virol 2007. Fig 2: Da Devare SG, J Med Virol 2007. Da Nick et al, J Med Virol 2007. Reduction in New HIV Diagnoses in BC: Testing, HAART, and Community VL. ≥ 50,000. 3500-9999. 500-3499. 12,000. 1400. < 500.

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slide34
Fig 2: Da Devare SG, J Med Virol 2007

Fig 2: Da Devare SG, J Med Virol 2007

Fig 2: Da Devare SG, J Med Virol 2007

reduction in new hiv diagnoses in bc testing haart and community vl
Reduction in New HIV Diagnoses in BC: Testing, HAART, and Community VL

≥ 50,000

3500-9999

500-3499

12,000

1400

< 500

HIV-1 RNA, copies/mL

Censored at the time of death or move

10,000

1200

8000

1000

New HIV+diagnoses (all)

800

New HIV+ Diagnoses (n)

6000

Patients (n)

600

10,000-49,999

4000

400

2000

200

0

0

1996

1997

1998

1999

2000

2001

2002

2003

2004

2005

2006

2007

2008

2009

  • Period of declining new HIV diagnoses in BC coincident with increased HIV testing rates, increased uptake of antiretroviral therapy, and decrease in community viral load (1996-2008)
    • Decline in new HIV diagnoses despite increases in syphilis, gonorrhea, chlamydia

Montaner J, et al. CROI 2010. Abstract 88LB. Reproduced with permission.

slide46
The decline of HIV DNA values during an effective therapy was directly related

to baseline HIV DNA and HIV RNA values at baseline,

to the increase in the number of CD4 cells

to the achievement of a HIV RNA load <2.5 copies/ml.

Undetectable HIV DNA cellular load was achieved by 21.6% of patients at the follow-up time point and significantly correlated with lower baseline cellular HIV DNA values and being in the primary stage of infection when therapy started.

In conclusion, early treatment facilitated the achievement of undetectable levels of plasma viraemia and cellular HIV DNA and a better recovery of CD4 lymphocytes. HIV DNA level before and during highly active antiretroviral therapy may be used as a new tool for monitoring treatment efficacy

Parisi et al, J Clin Microb 2012

distribuzione mondiale dei sottotipi hiv 1
1Distribuzione mondiale dei sottotipi HIV-1

A (1519)

B (16067)

C (737)

CRF01_AE (625)

CRF02_AG (51)

CRF03_AB (84)

D (369)

F (173)

G (229)

H (21)

J (8)

K (3)

N (1)

O (113)

Other recomb. (178)

slide55
Sottotipi HIV-1 in Africa (1995-2000)

Costad’avorio

Senegal

Niger

Mali

Benin

Nigeria

Kenya

Tanzania

Etiopia

Uganda

Ciad

Camerun

Gabon

Zambia

Sud Africa

DRC

grazie per l attenzione

GRAZIE PERL’ATTENZIONE

Paulus Furst 1656:

“illustration of protective clothing

against plague”

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