Relationship of Early Obesity & Adult Health. Mike F. Weaver, Dr.P.H. Guest Lecturer. Children, Adolescents & Diabetes Mellitus.
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Type 2 (non-insulin dependent DM or late-onset diabetes)- insulin-producing (beta) cells produce normal or above-normal levels of insulin, but because of the decline in the number of insulin receptors in target cells, cells are unresponsive to insulin.
Results: Impaired glucose tolerance was detectd in 25% of the 55 obese children (4-10 years of age) and 21% of the 112 obese adolescents (11-18 years of age); silent Type 2 DM was identified in 4% of obese adolescents.
Conclusions: Impaired glucose tolerance is highly prevalent among children and adolescents with severe obesity, irrespective of ethnicity.
Amputations- especially lower extremities in DM, result from inevitable elevations in blood glucose levels that occur periodically over the years. Gangrene, the local demise of soft tissue due to loss of blood supply, causes amputations.