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EPAC = Exchange Proteins Activated by cAMP Two isoforms : EPAC1 and EPAC2 PowerPoint Presentation
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EPAC = Exchange Proteins Activated by cAMP Two isoforms : EPAC1 and EPAC2 - PowerPoint PPT Presentation


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Key Terms. EPAC = Exchange Proteins Activated by cAMP Two isoforms : EPAC1 and EPAC2 Previous evidence demonstrates deletion of both genes reduces glutamate release (Yang et al., 2012) . SUR1 = K ATP channel type-1 sulfonylurea receptor

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Key Terms

  • EPAC = Exchange ProteinsActivated by cAMP
    • Twoisoforms: EPAC1 and EPAC2
    • Previousevidencedemonstratesdeletion of bothgenes reduces glutamate release (Yang et al., 2012) .
  • SUR1 = KATPchannel type-1 sulfonylureareceptor
  • Kir6.1 = KATP channelsubunitassociateswith SUR1
  • EPAC bindsspecifically to SUR1 receptorconsisting of aminoacids 859-881
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EPSCswereevoked by pair-pulsed stimulation of the mossyfibertracks in the hilus of the dentategyrus (CA3-CA3 synaptic inputs).

Reording in the presence of 10μm BMI and 20μm NBQX at holding of +60mv

conclusions
Conclusions:
  • Geneticdeletion of EPAC genes or disruption of EPAC-SUR1 interaction increasesopeningprobability.
    • EPAC controls KATPchannelactivity via tonic inhibition of SUR1 receptor
  • Other EPAC variants have been found in Austism Spectrum Disorder Patients
    • Possible molecularmechanism