Summary. Non Coding RNA MiRNA History mi RNA F unctions Mi RNA Pathway mi RNA role in regulation of teranscription Data-based Modeling of the JAK-STAT Pathway Negative Regulation of the JAK-STAT pathwey Cancers caused by mi- RNA 155. MiRNA History.
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JAK family : JAK1, JAK2, JAK3 and TYK2
Nat. Rev. Mol. Cell Biol. 2002 3:651
Ligand Jak kinases STATs
Type I IFN- IFNa or IFNb Tyk2, Jak1 STAT1, STAT2
Type II IFN-IFNg Jak1, Jak2 STAT1
IL-2 Jak1, Jak3 STAT5
IL-4 Jak1, Jak3 STAT5
IL-7 Jak1, Jak3 STAT5
IL-6 Jak2 STAT3
IL-11 Jak2 STAT3
Modified from Gene 2002 285:1
cytokine inducible family of genes which function as
feedback inhibitors of signaling
SOCS recruits ub conjugation complex SOCS binds activated Jak preventing
leading to Jak degradation. substrate access.
Multisubunit E3 ub-ligases
microRNA expression profiling can distinguish cancers according to diagnosis and developmental stage of the tumour to a greater degree of accuracy than traditional gene expression analysis
Aberrant expression of specific microRNAs has now been associated with many types of cancer including solid and haematopoietic tumours
Cancer (Calin and Croce 2006; Ura et al 2008; Stamatopoulos et al 2009…)
Cardiovascular disease (Latronico et al. 2007; van Rooij and Olson 2007)
Schizophrenia (Hansen, et al. 2007; Perkins et al. 2007)
Renal misfunction (Williams 2007)
Tourette syndrome (Esau and Monia 2007)
Psoriasis (Sonkoly et al. 2007)
Muscle disorders (Eisenberg et al. 2007),
X fragile syndrome (Fiore and Schratt 2007)
Policitemia vera (Bruchova et al. 2007)
Diabetes (Williams 2007)
Chronic hepatitis (Murakami et al. 2006)
AIDS (Hariharan etal. 2005)
Obesity (Weiler et al. 2006, Lovis et al. 2008, Xie et al. 2009).
Esquela-Kerscher & Slack. Nature Reviews Cancer. 2006.