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Original Article Childhood Body-Mass Index and the Risk of Coronary Heart Disease in Adulthood. Jennifer L. Baker, Ph.D., Lina W. Olsen, Ph.D., and Thorkild I.A. Sørensen, M.D., Dr.Med.Sci. N Engl J Med Volume 357(23):2329-2337 December 6, 2007. Study Overview.

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Original article childhood body mass index and the risk of coronary heart disease in adulthood

Original ArticleChildhood Body-Mass Index and the Risk of Coronary Heart Disease in Adulthood

Jennifer L. Baker, Ph.D., Lina W. Olsen, Ph.D., and Thorkild I.A. Sørensen, M.D., Dr.Med.Sci.

N Engl J Med

Volume 357(23):2329-2337

December 6, 2007


Study overview
Study Overview

  • In this Danish study, body-mass index in childhood was associated with coronary heart disease (CHD) events in adulthood

  • The association was stronger in boys than in girls, and the risk of an event in adulthood increased in both sexes as the child's age increased from 7 to 13 years

  • These important data focus attention on the public health significance of the epidemic of childhood obesity


Original article childhood body mass index and the risk of coronary heart disease in adulthood

Mean BMI Values for 276,835 Children 7 to 13 Years of Age

Baker JL et al. N Engl J Med 2007;357:2329-2337


Original article childhood body mass index and the risk of coronary heart disease in adulthood

Body-Mass Index (BMI) in Childhood and the Risk of Coronary Heart Disease (CHD) in Adulthood

Baker JL et al. N Engl J Med 2007;357:2329-2337


Original article childhood body mass index and the risk of coronary heart disease in adulthood

Adjusted Hazard Ratio for the Risk of a Fatal or a Nonfatal CHD Event in Adulthood in Relation to a 1-Unit Increase in BMI z Score in a Cohort of 276,835 Children

Baker JL et al. N Engl J Med 2007;357:2329-2337


Original article childhood body mass index and the risk of coronary heart disease in adulthood

Adjusted Hazard Ratio for the Risk of Any CHD Event in Adulthood in Relation to a 1-Unit Increase in BMI z Score in Models Unadjusted and Adjusted for Birth Weight in a Cohort of 208,433 Children

Baker JL et al. N Engl J Med 2007;357:2329-2337


Original article childhood body mass index and the risk of coronary heart disease in adulthood

Predicted Risk of Having a CHD Event between 25 and 60 Years of Age in a Cohort of 276,835 Children of Average or Higher-Than-Average BMI

Baker JL et al. N Engl J Med 2007;357:2329-2337


Conclusion
Conclusion of Age in a Cohort of 276,835 Children of Average or Higher-Than-Average BMI

  • Higher BMI during childhood is associated with an increased risk of CHD in adulthood

  • The associations are stronger in boys than in girls and increase with the age of the child in both sexes

  • Our findings suggest that as children are becoming heavier worldwide, greater numbers of them are at risk of having CHD in adulthood