clinical translational research center ctrc n.
Download
Skip this Video
Loading SlideShow in 5 Seconds..
Clinical & Translational Research Center (CTRC) PowerPoint Presentation
Download Presentation
Clinical & Translational Research Center (CTRC)

Loading in 2 Seconds...

play fullscreen
1 / 49

Clinical & Translational Research Center (CTRC) - PowerPoint PPT Presentation


  • 152 Views
  • Uploaded on

Clinical & Translational Research Center (CTRC). Clinical & Translational Science Award (CTSA). Structure of the Penn CTSA. Translational Biomedical Imaging Center (TBIT). Biomedical Informatics In Translation (BIIT). Clinical and Translational Research Center (CTRC).

loader
I am the owner, or an agent authorized to act on behalf of the owner, of the copyrighted work described.
capcha
Download Presentation

Clinical & Translational Research Center (CTRC)


An Image/Link below is provided (as is) to download presentation

Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author.While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server.


- - - - - - - - - - - - - - - - - - - - - - - - - - E N D - - - - - - - - - - - - - - - - - - - - - - - - - -
    Presentation Transcript
    1. Clinical & Translational Research Center (CTRC)

    2. Clinical & Translational Science Award (CTSA)

    3. Structure of the Penn CTSA Translational BiomedicalImaging Center (TBIT) Biomedical Informatics In Translation (BIIT) Clinical and Translational Research Center (CTRC) Personalized Medicine in Translation (PERMIT) Chemical Biology In Translation (CBIT)

    4. Transcendant themes of the Penn CTSA • Translational therapeutics • Promote and facilitate translation of preclinical studies into proof of concept and mechanistic studies in humans • Bridging the pediatrics / adult divide • Education and investment in human capital

    5. CTRC • Formed in 2006 • Joining of 2 previous GCRCs (PENN 1965, CHOP 1962) • Expanded services, functions and clinical cores • Competitive renewal phase to start this July

    6. CTSA Clinical & Translational Research Center • Inpatient & outpatient research beds • Clinical cores • Nutrition, Neurobehavioral, Sleep, Cardiovascular, Pulmonary • Translational core lab • Informatics support • Biostatistical support • Junior and senior investigator grants

    7. CTRC administration

    8. Active CTRC protocols PENN CHOP

    9. No. of protocols by CHOP division

    10. No. of protocols by Penn division

    11. Clinical Research Space(CHOP) • Inpatient: 5 West • 4 beds • Outpatient: Main & 3550 • 4 exam rooms • 6 chairs • Consultation rooms • Lab processing

    12. Research Nursing

    13. Research Nursing (CHOP)(Dr. Medoff-Cooper) • Nursing services: • Phlebotomy / IV infusions • Medication administration • Vital signs • Patient monitoring • Study specific requirements, e.g. ECGs • Basic laboratory processing / shipping • Space for consenting of study participants, physical exams, questionnaire administration • Limited Saturday hours offered

    14. Scatterbed Nurses • ICUs • OR • ED • Clinics • Sleep lab • etc.

    15. Clinical research space(PENN) • HUP (1 Dulles) • Dedicated 8 bed inpatient unit • Outpatient units (5 single rooms; one large room with 5 chairs) • 2 consultation rooms • Penn Presbyterian Hospital (Mutch) • Dedicated outpatient unit (2 beds, 4 chairs)

    16. Research nursing (PENN) • Unit is open 24/7 • 16 nurses trained in research nursing • 1 nurse practitioner

    17. CTSA cores • Equipment • Personnel • Scientific and technical oversight

    18. Core design • Medical and technical directorship • Combined adult / pediatric components • Research quality control • Charge-back mechanism with low rates (need to budget into new grant proposals)

    19. Nutrition Core Babette Zemel, PhD

    20. Nutrition Laboratory • Anthropometrics & growth • Body composition (BodPod, DXA) • Resting energy expenditure • Bone density, growth (DXA, pQCT, knee height) • Muscle strength

    21. Bionutrition Research Unit(Dr. Compher) • Analyze diet records • Nutrition education / consult • Plan study meals • Design & test recipes • Provide special diets (metabolic kitchen)

    22. Cardiovascular Core Emile Mohler, MD & Meryl Cohen, MD

    23. Vascular studies • Brachial artery reactivity testing • Carotid intimal medial thickness testing • Arterial duplex ultrasound • Venous duplex ultrasound • Ankle-brachial index • Pulse wave velocity • NIRS of skeletal muscle

    24. Pediatric tests • Echo (with or without sedation) • EKG

    25. Pulmonary Core Hank Mayer, MD

    26. Pulmonary Core PFTs: Outpatient & inpatient Bronchodilator / metacholine challenges Exhaled NO; breath condensates Infant PFTs

    27. Behavioral Neuroscience Core Jerilynn Radcliffe, PhD

    28. Behavioral Neuroscience Core • Neuropsychological testing (infancy through adulthood) • Training and supervision for research assistants to conduct neuropsychological testing • Consultation on study design, test interpretation, manuscript preparation

    29. Sleep Core Allan Pack, MD PhD, Alex Mason, MD PhD

    30. Sleep Core • Polysomnography • Multiple sleep latency tests • Actigraphy

    31. Investigational Drug ServiceK. Rockwell • Procurement / storage / dispensing study drugs • Randomization • Placebos • Maintains study randomization schedule to allow for unblinding in case of emergency, 24/7

    32. Informatics Core(E. Escobar)

    33. Informatics Core • Case report forms (CRF) development • Development and maintenance of databases • Storage of study databases on a secured server • Assistance with proprietary software • New initiatives in conjunction with CTSA BIIT

    34. Biostatistics Core • Assist with statistical analysis plans • Power calculations • Help revise protocols after Council reviews • Data analysis for K23 & JIPGP recipients, pilot studies Drs. Cucchiari, Gallagher & Shults

    35. Translational Core Laboratory Charles Stanley MD, Muredoch Reilly MD

    36. BIIT TRANSLATIONAL CORE LABORATORIES Pre-Clinical Laboratories Sample Collection Clinical Sites Sample Collection Sample Processing TCL Bioinformatics Freezer Storage Molecular Biology Core Biochemistry Core Cell Biology Core Novel Bioassay Development Proteomic Core Lipidomic Core DERC RIA Biomarker Core Lipid/CV Biomarker Lab Pathology BioResources

    37. Biochemistry services • ELISA, RIA, spectrophotometry, SPE, TLC, HPLC, platelet aggregation and function studies • 69 types of ELISA, enzymatic and RIA assays • Collection, processing, shipping, storage

    38. Translational Core Laboratory • Molecular Markers • DNA sequencing/Re-sequencing/Mutation detection • Sequencing prep Data analysis • TaqMan SNP genotyping • Microsatellite marker/LOH analysis/Fragment analysis • Real-time TaqMan PCR Gene Expression Analysis • PCR/Gel Analysis/Primer Design • Establishment of EBV transformed cell lines from • fresh or frozen PBMCs

    39. How do I apply?

    40. Application process (1) • Joint IRB/CTRC reviews via eIRB • Answer “Yes” to question asking if you will use the CTRC – links to eCTRC module • Reciprocity with Penn • Annual reviews concurrent with IRB reviews

    41. Application process (2) Resources committee meets monthly Rapid feedback May be asked to present to CTRC Council or Staff meeting You MUST acknowledge the CTSA in your publications

    42. Charge-back mechanism Minimal charges to cover actual costs of the study Discuss with CTRC before submitting grants CTRC provides blurbs to include in your grant budget justifications Charges may go up soon 

    43. GRANTS

    44. Junior Investigator Pilot Grants • Junior investigators (rank < associate professor) • Patient oriented research • Primarily pilot studies for generation of preliminary data for grants • Use of CTRC resources • $20,000 / yr for 1-2 years

    45. JIPGP recipients 2010 • Michelle Denburg, MD,MSCE, Nephrology, Pediatrics Vitamin D Status in the Setting of Nephrotic-Range Proteinuria • Sara DeMauro, MD,MSCE, Neonatal-Perinatal, Pediatrics The Role of Serial Echocardiography to Detect an Asymptomatic Patent Ductus Arteriosus (PDA) in Very Low Birth Weight (VLBW) Infants: A Pilot Randomized Controlled Trial • Kimberly Lin, MD, Cardiology, Pediatrics Cardiac biomarkers during anthracycline therapy and the risk of cardiotoxicity • Frances Balamuth, MD, PhD, Emergency Medicine, Pediatrics Characterization of Inflammatory Biosignatures in Adolescent Females with Abdominal Pain • Andrew Calabria, MD, Endocrinology, Pediatrics Adjunctive Measures of Glycemic Control in Children with Post-prandial Hypoglycemia after Fundoplication • Michael Grandner, PhD, Center for Sleep and Respiratory Neurobiology, Medicine Health and Performance Outcomes Associated with Short Sleep Duration • James Lee, MD, Pulmonary, Allergy, and Critical Care, Medicine Dietary Antioxidant Therapy for the Prevention of Primary Graft Dysfunction in Lung Transplantation

    46. CTSA grants • JIPGP ($20-40,000) • TAPITMAT ($150,000) • Transdisciplinary awards program in translational medicine and therapeutics) • TBIC ($25-50,000) • Translational Biomedical Imaging Center) • CBIT ($15,000) • Chemical Biology in Translation) • K12

    47. http://www.itmat.upenn.edu/ctrc/index.shtml