advancement of science and research on hiv n.
Download
Skip this Video
Loading SlideShow in 5 Seconds..
Advancement of Science and Research on HIV PowerPoint Presentation
Download Presentation
Advancement of Science and Research on HIV

Loading in 2 Seconds...

play fullscreen
1 / 8

Advancement of Science and Research on HIV - PowerPoint PPT Presentation


  • 90 Views
  • Uploaded on

Advancement of Science and Research on HIV. Discussing past and future accomplishments of HIV research. Françoise BARR É-SINOUSSI Regulation of Retroviral Infections Unit Department of Virology. HIV/SIV Pathogenesis: Lessons from distinct outcome in Human & NHP. Natural Control.

loader
I am the owner, or an agent authorized to act on behalf of the owner, of the copyrighted work described.
capcha
Download Presentation

PowerPoint Slideshow about 'Advancement of Science and Research on HIV' - gwyn


An Image/Link below is provided (as is) to download presentation

Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author.While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server.


- - - - - - - - - - - - - - - - - - - - - - - - - - E N D - - - - - - - - - - - - - - - - - - - - - - - - - -
Presentation Transcript
advancement of science and research on hiv
Advancement of Science and Research on HIV

Discussing past and future accomplishments of HIV research

Françoise BARRÉ-SINOUSSI

Regulation of Retroviral Infections Unit

Department of Virology

hiv siv pathogenesis lessons from distinct outcome in human nhp
HIV/SIV Pathogenesis: Lessons from distinct outcome in Human & NHP

Natural Control

Acquired Control

VNP

HUMAN

HAART, clinical trials

VISCONTI patients

EU

LNTP

HIC

Berlin Patient

Vaccinees (RV144…)

HIV-2

AFRICAN Natural Host

Pre-clinical studies for prevention and treatment….

ASIAN NHP

SIC

LNTP

Vaccine studies (SIVmac239Nef…)

slide3

HIV/SIV pathogenesis

Adapted from G. Silvestri

slide4

Early Response to HIV

HIV Reservoirs

Inflammation/Activation

A.McMichael & B.Haynes, Nat. Rev.Immunol. 2010

early determinants of hiv pathogenesis
Early determinants of HIV pathogenesis
  • Viral reservoirs and HIV persistence:
  • Residual ongoing replication?
  • Survival/proliferation of TCM

Inflammation and Chronic immune activation

Host & Virus genetic polymorphism

?

What do we need to consider to achieving control/protection?

Innate & intrinsic immunity: pDC, NK antiviral activity, Restriction factors (APOBEC, TRIM5a,Tetherin, p21, Samhd1…)

Adaptative immunity: Suppressive CD8 Tcell response (HICs), Nabs and other Ab functions, like ADCC…

discussing points
Discussing points
  • Need to identify the very, very first events and signals resulting in activation and viral persistence? Role of viral determinants?
  • Relevance of NHP models for studying these early mechanisms and how to control them?
  • Needs for additional models (primate models, humanized mice…) to identify correlates of protection against viral replication and/or viral acquisition?
long lasting protection against virus acquisition
Long lasting protection against virus acquisition

Will it be possible to develop a protective vaccine only based on Env immunogen?

From J Mascola

Peripheral vs mucosal immunity

How to induce long term mucosal protective immunity?

slide8

Learning beyond HIV…

Cancer,

lymphomas

Cardiovascular

diseases

Ageing

diseases

Immune defects,

Inflammatory

and

autoimmune maligancies

?

?

Chronic HIV Infection on

HAART