Advancement of Science and Research on HIV. Discussing past and future accomplishments of HIV research. Françoise BARR É-SINOUSSI Regulation of Retroviral Infections Unit Department of Virology. HIV/SIV Pathogenesis: Lessons from distinct outcome in Human & NHP. Natural Control.
Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author.While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server.
Discussing past and future accomplishments of HIV research
Regulation of Retroviral Infections Unit
Department of Virology
HAART, clinical trials
AFRICAN Natural Host
Pre-clinical studies for prevention and treatment….
Vaccine studies (SIVmac239Nef…)
Adapted from G. Silvestri
A.McMichael & B.Haynes, Nat. Rev.Immunol. 2010
Inflammation and Chronic immune activation
Host & Virus genetic polymorphism
What do we need to consider to achieving control/protection?
Innate & intrinsic immunity: pDC, NK antiviral activity, Restriction factors (APOBEC, TRIM5a,Tetherin, p21, Samhd1…)
Adaptative immunity: Suppressive CD8 Tcell response (HICs), Nabs and other Ab functions, like ADCC…
Will it be possible to develop a protective vaccine only based on Env immunogen?
From J Mascola
Peripheral vs mucosal immunity
How to induce long term mucosal protective immunity?
Chronic HIV Infection on