Advancement of Science and Research on HIV. Discussing past and future accomplishments of HIV research. Françoise BARR É-SINOUSSI Regulation of Retroviral Infections Unit Department of Virology. HIV/SIV Pathogenesis: Lessons from distinct outcome in Human & NHP. Natural Control.
Discussing past and future accomplishments of HIV research
Regulation of Retroviral Infections Unit
Department of Virology
HAART, clinical trials
AFRICAN Natural Host
Pre-clinical studies for prevention and treatment….
Vaccine studies (SIVmac239Nef…)
Adapted from G. Silvestri
A.McMichael & B.Haynes, Nat. Rev.Immunol. 2010
Inflammation and Chronic immune activation
Host & Virus genetic polymorphism
What do we need to consider to achieving control/protection?
Innate & intrinsic immunity: pDC, NK antiviral activity, Restriction factors (APOBEC, TRIM5a,Tetherin, p21, Samhd1…)
Adaptative immunity: Suppressive CD8 Tcell response (HICs), Nabs and other Ab functions, like ADCC…
Will it be possible to develop a protective vaccine only based on Env immunogen?
From J Mascola
Peripheral vs mucosal immunity
How to induce long term mucosal protective immunity?
Chronic HIV Infection on