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Comparative Study on Tubercle Bacilli Inoculation in Guinea Pigs

Analyzing the effects of varying doses of tubercle bacilli inoculation on guinea pigs with different resistance levels. Comparison of mortality rates and hazard functions. Includes examples and data visualization techniques.

gwenifer-allen
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Comparative Study on Tubercle Bacilli Inoculation in Guinea Pigs

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  1. Ch.10 Summarizing Data 10.2 Methods based on the C.D.F

  2. Figure10.1

  3. Eg：Guinea pig 接種不同劑量的結核菌(tubercle bacilli) Control group(107隻) Inoculated group ⅠⅡⅢⅣⅤ各72隻,按照劑量順序排列 表10.2.1 表10.2.2 在Control group及較低量的注射劑群並非所有的天竺鼠都死，因此在 Control group中只有65筆data,在DoseⅠ及DoseⅡ分別都只有60,67筆data 目的：比較對不同抵抗力的天竺鼠，其增加注射劑量的效果差別！ Eg：對Group Ⅲ及Ⅳ (1)對抵抗力較弱的天竺鼠(其生命中10% weakest，即在圖中的y軸畫 0.9的水平線其所對應的x軸，即為此10% weakest的最長生命期) Group Ⅲ及Ⅳ的差距約在50天 (2)然而對抵抗力較強的天竺鼠，Group Ⅲ及Ⅳ的差距大約在100天左右

  4. Eg：天竺鼠的例子 (1)一開始的hazard function 在每個group中都很小 (2)隨著注射劑量的增加，其瞬時死亡率不僅增加且其增加的速率也隨著劑量的增加而加快 E.g.Ⅲ及Ⅴ的比較，Ⅴ較Ⅲ其instant mortality rate 增加的速率較 快，且最後其曲線所相對的斜率也較Ⅲ的相對斜率更大 Figure10.2

  5. Figure10.3

  6. Figure10.4 Figure10.5

  7. Ex：Cleveland et al. (1974) 空氣污染研究,比較星期天與周日間污染物分配之變化 x 和 y 的尺度不同

  8. 10.3 Histograms, Density Curves, and Stem-and-Leaf Plots Figure10.8 (1)Histograms If the bin width is too small→the histogram is too ragged If the bin width is too wide→the shape is over smoothed and obscured Eg：

  9. Figure10.9

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