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Fenobam

Fenobam. Devon Harvey Stephanie Miller. Physical Properties. Chemical Formula : C 11 H 11 ClN 4 O 2 Molar Mass: 284.699 g/ mol Density: 1.47g/cm 3 Solubility: 30 mg/L. History .

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Fenobam

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  1. Fenobam Devon Harvey Stephanie Miller

  2. Physical Properties Chemical Formula: C11H11ClN4O2 Molar Mass: 284.699 g/mol Density: 1.47g/cm3 Solubility: 30 mg/L

  3. History Fenobam is a relatively new molecule. It was developed by McNeil Laboratories in the late 1970’s. It was created with the intent to be a new anxiolytic drug. Anxiolytic drugs treat anxiety and similar psychological symptoms. The way it works is by acting as an antagonistic reactant with the receptor protein mGluR5. The amino acid L-glutamate is a prominent excitatory molecule that binds to mGluR5. Fenobam inhibits this reaction so as to keep the mind in a calmer state.

  4. Health effects Fenobam was never able to be sold commercially because of some of the side affects. These include: • Amnesia • Delusions • Hallucinations Fenobam can also cause damage is contacted directly. • If it is inhaled, it will mostly likely cause irritation • It may be absorbed through the skin and cause irritation • May cause eyes to become agitated • If swallowed, it may be lethal

  5. References http://www.chembase.com/cbid_216215.htm http://www.cas.org/motw/fenobam.html http://www.sciencedirect.com/science/article/pii/S0960894X06013989 http://en.wikipedia.org/wiki/Fenobam http://datasheets.scbt.com/sc-202608.pdf

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