This presentation summarizes the caries formation process and fluoride mode of action
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Initial subsurface demineralization
1. Initial subsurface demineralization
Extension of demineralized
zone towards dentine
Collapse of surface layer to form cavity
3. Collapse of surface layer to form cavity
Extension of caries lesion into dentine
Extension of caries into pulp
Possible formation of apical abscess
1. Collins WJN, et al. A Handbook for Dental Hygienists. 3rd edition. Oxford: Wright, 1992.2. Clarkson BH, et al. Caries Res 1991;25:166-173.
Figure 1. Sectioned, extracted tooth with three caries lesions
Figure 2. A single caries lesion showing bacterial invasion in dentinal tubules
Salivary [Ca Treatment2+]
Salivary [F-]Demineralization and remineralization
Adapted from Aoba T. Oral Dis 2004;10:249-257.
1. Gao XJ, et al. J Dent Res 2001;80:1834-1839.
©iStockphoto.com/ Wolfgang Amri
F- TreatmentFluoride effect on remineralization and demineralization of enamel
Inhibit acid generation from plaque bacteria4
1. Silverstone LM. Clinical uses of fluoride 1985;153-175.2. Featherstone JD, et al. J Dent Res 1990;69:620-625.3. Aoba T. Crit Rev Oral Biol Med 1997;8:136-153.4. Briner WW & Francis MD. Arch Oral Biol 1962;7:541-550.
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1. Newby CS, et al. J Clin Dent 2006;17:94-99.2. Lynch RJ, et al. Int Dent J 2005;55:175-178.3. Bowen WH. J Royal Soc Med 1995;88:505-507.4. Stephen KW, et al. Int Dent J 1994;44:287-295.
1. Zero DT, et al. Caries Res 2007;41:268-334.
Data expressed as least square mean ± S.D. n=39*p<0.01 compared with 1000ppm F MFP/450ppm NaF
1. Newby EE, et al. 54th ORCA Congress. July 2007. Caries Res 2007;41:328 (abs 173).
1. Zero DT, et al. Caries Res 2007;41:268-334. 2. Zero DT, et al. Presented at the 85th General Session & Exhibition of the International Association for Dental Research (IADR), New Orleans, USA, 2007.3. Newby EE, et al. 54th ORCA Congress. July 2007. Caries Res 2007;41:328 (abs 173).
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