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Role of Vaccination in Control of BVDV. 2004 NCBA Cattleman’s College. Dan Grooms DVM, Michigan State University, College of Veterinary Medicine. Goal For The Day. Type of BVDV vaccines available Role of vaccines in BVDV control. Seventh Edition of Compendium of Veterinary Products

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slide1

Role of Vaccination in Control of BVDV

2004 NCBA Cattleman’s College

Dan Grooms DVM, Michigan State University, College of Veterinary Medicine

goal for the day
Goal For The Day
  • Type of BVDV vaccines available
  • Role of vaccines in BVDV control
slide3
Seventh Edition of Compendium of Veterinary Products

147 BVDV vaccine combinations available

types of bvdv vaccines
Types of BVDV Vaccines
  • Killed or inactivated
  • Modified-live or attenuated
killed bvdv vaccines
Advantages

Generally safer

Dead virus

Pregnant cows

Handling

More stable

Can use over time if handled correctly

Disadvantages

Protection not as good

Duration

Breadth

Immune response different than live virus

More expensive

Triangle 10 ds = $11.85

Pyramid 10 ds = $ 9.69

Killed BVDV Vaccines
modified live bvdv vaccines
Advantages

Generally better protection

Duration

Breadth

Immune response more closely mimics natural exposure

Cheaper

Express 10 ds = $ 8.59

Elite 10 ds = $10.65

Disadvantages

Safety

Live replicating organism

Potential for transmission

Potential for mutation

Potential of fetal infection

Handling

Susceptible to inactivation

Must use once mixed

Modified-Live BVDV Vaccines
type of virus in the vaccine

2

1a 1b

Type of Virus in The Vaccine

1 a & b

2

Continuum of Antigenicity

slide10

Location

Exposure

Time of Year

Type of Vaccine

Contraindications

Considerations

IN/SQ/IM

Management

Economics

Animal Use

slide11

Pigs

Sheep

Mucosal Disease

Deer?

Thrombocytopenia

Acute Infection

Normal

Acute Death

Poor

Performance

BRD

Diarrhea

Immunosuppression

Immunosuppression

Fetal Infection

Subclinical Infection

Persistent

Infection

Abortions

Normal

Congenital

Defects

“Weak Calf”

Syndrome

slide12

Pigs

Sheep

Mucosal Disease

Deer?

Thrombocytopenia

Acute Infection

Normal

Acute Death

Poor

Performance

BRD

Diarrhea

Immunosuppression

Immunosuppression

Fetal Infection

Subclinical Infection

Persistent

Infection

Abortions

Normal

Congenital

Defects

“Weak Calf”

Syndrome

fetal protection against bvdv
Fetal Protection Against BVDV

* Protected/Challenged

bvdv vaccination and fetal protection
BVDV Vaccination and Fetal Protection

Vaccination for BVDV is not 100%!! Combine with biosecurity and PI management

Point #1

antigenic diversity

2

1a 1b

Antigenic Diversity

Does a vaccine containing type 1 BVDV protect against a type 2 BVDV challenge (or vice versa)???????

slide17

Control

Control

100% PI’s

MLV Type 1 Vaccine

Day 75 Gestation

Type 1 Challenge

Type 2 Challenge

10 Normal

2 PI’s

11 Normal

8 PI’s

83% Protection

58% Protection

Cortese et al AJVR 1998;59:1409

Brock et al Vet Thera 2001;2:354

bvdv vaccination and fetal protection18
BVDV Vaccination and Fetal Protection

Vaccination for BVDV is not 100%!! Combine with biosecurity and PI management

Point #1

It is desirable to provide broad protection against antigenic diversity of BVDV

Point #2

slide20

Infertility

Normal/Abnormal Seropositive

Congenital Defects

Immunotolerance-PI’s

Abortion

EED

0 1 2 3 4 5 6 7 8 9

Month

Time line of BVDV effects on Bovine Reproduction

bvdv vaccination and fetal protection21
BVDV Vaccination and Fetal Protection

Vaccination for BVDV is not 100%!! Combine with biosecurity and PI management

Point #1

It is desirable to provide broad protection against antigenic diversity of BVDV

Point #2

Timing of vaccination should maximize immunity in early pregnancy

Point #3

slide22

Pigs

Sheep

Mucosal Disease

Deer?

Thrombocytopenia

Acute Infection

Normal

Acute Death

Poor

Performance

BRD

Diarrhea

Immunosuppression

Immunosuppression

Fetal Infection

Subclinical Infection

Persistent

Infection

Abortions

Normal

Congenital

Defects

“Weak Calf”

Syndrome

protection against acute bvdv disease
Protection Against Acute BVDV Disease
  • Most experimental studies show good protection against acute disease.
  • Most studies show protection when vaccine virus and challenge virus are different (type 1 vaccine, type 2 challenge).
  • No real good large scale field trials looking at vaccine efficacy.
slide24

Performance Of Feedlot Cattle Exposed To Animals Persistently Infected With Bovine Viral Diarrhea Virus

D.L. Grooms and K.V. Brock

bvdv vaccination and acute infection
BVDV Vaccination and Acute Infection

Protection requirements may not be as stringent as for fetal protection …reasonable cross protection

Point #1

bvdv vaccination and acute infection29
BVDV Vaccination and Acute Infection

Protection requirements may not be as stringent as for fetal protection …reasonable cross protection

Point #1

Vaccination for BVDV is not 100%!! Combine with biosecurity and PI management

Point #2

control and prevention of bvdv
Control and Prevention of BVDV
  • Biosecurity
  • Seek and Destroy PI’s
  • Vaccination Program
    • Strategic in Timing
    • Broad Protection Against Virus Diversity
slide31

Dan Grooms DVM

Michigan State University

College of Veterinary Medicine

517-432-1494

groomsd@cvm.msu.edu