Dengue. Professor.Shivaprasad. Dengue. The word dengue is derived from African word denga: meaning fever with hemorrhage . Is caused by virus transmitted of bites of mosquito aedes. DEFINITION.
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Prospective study of dengue virus infection in Thai children:
Blood levels of C1q, C3, C4, C5, C6, C7, C8 and C3 proactivator are depressed.
C3 catabolic rates elevated.
The blood clotting and fibrinolytic system are activated.
Recent studies suggest a role for tumor necrosis factor and interferon gamma.
As yet neither the mediator of vascular permiability nor complete mechanism of bleeding has been identified.
Focal midzonal necrosis
Hyperplasia of the Kupffer Cells.
Non nucleated cells with vacuolated acidophilic cytoplasm resembling councilmanbodies are seen in the sinusoids.
- 24,000 deaths/yr.
To know the clinical course of Dengue infections.
To analyze the outcome of Dengue in children.Objectives
Vani vilas children’s hospital, Bangalore.
STUDY DESIGN :
Institution based case series study.
Standard definitions were used to define
Standard WHO treatment guidelines were
followed in treatment
ATYPICAL features are also seen.
2 had co - morbid conditions, 3rd an infant, terminally ill referred for ventilator care.
Reduction in breeding sites
Application of larvicides
Alternatively, a significant reduction in population may be effected by closely spaced application of adulticides.