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http://target.cancer.gov. Areas for TARGET Initiative Research Focus. Underlying premise: Genes that are altered in expression, copy number, or LOH and mutation will highlight cellular pathways for therapeutic exploitation Approach:

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areas for target initiative research focus
Areas for TARGET Initiative Research Focus

Underlying premise: Genes that are altered in expression, copy number, or LOH and mutation will highlight cellular pathways for therapeutic exploitation

Approach:

  • High-throughput array-based technologies to comprehensively characterize genomic and transcriptomic profiles
  • Gene resequencing to identify genes that are consistently altered in specific childhood cancers
  • Functional validation to validate putative therapeutic targets
cancer target initiative strategy for all and neuroblastoma projects
Cancer TARGET Initiative Strategy for ALL and Neuroblastoma Projects

Disease Expertise –

COG Disease

Committee

Genomic Characterization

Expertise

Gene

Sequencing Expertise

Transcriptomic

Characterization

Expertise

Clinical

Specimens

speakers for the all and neuroblastoma target teams
Speakers for the ALL and Neuroblastoma TARGET Teams
  • Stephen P. Hunger, MD (ALL TARGET)
    • Professor and Ergen Family Chair in Pediatric Cancer
    • Director, Center for Cancer and Blood Disorders
    • Chief, Pediatric Hematology/Oncology/BMT
    • University of Colorado Denver and The Children’s Hospital
    • Chair, COG ALL Committee
  • John M. Maris, MD (Neuroblastoma TARGET)
    • Giulio D'Angio Associate Professor of Pediatrics
    • Chief, Division of Oncology
    • Director, Center for Childhood Cancer Research
    • Children's Hospital of Philadelphia
    • University of Pennsylvania School of Medicine
    • Chair, COG Neuroblastoma Committee
identifying more effective treatments for children with cancer
Identifying More Effective Treatments for Children with Cancer

TARGET

Discovery

Programs

Pediatric

Preclinical

Testing

Phase 1

Clinical Trial

(COG, NANT,

PBTC, CCR)

COG Definitive

Clinical Trial