Clinical and polisomnographic features of complex sleep apnea syndrome
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Clinical And Polisomnographic Features of Complex Sleep Apnea Syndrome. Handan INONU Tansu ULUKAVAK CIFTCI Oguz KOKTURK. Complex Sleep Apnea Syndrome (CompSAS).

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Clinical and polisomnographic features of complex sleep apnea syndrome

Clinical And Polisomnographic Features ofComplex Sleep Apnea Syndrome

Handan INONU

Tansu ULUKAVAK CIFTCI

Oguz KOKTURK


Complex sleep apnea syndrome compsas
Complex Sleep Apnea Syndrome (CompSAS)

  • Complex Sleep Apnea Syndrome (CompSAS) is a case characterized by appearing of central apneas or Cheyne-Stokes breathing pattern in some patients of Obstructive Sleep Apnea Syndrome (OSAS) which were applicated Continuous Positive Airway Pressure (CPAP)

    Sleep Breath 2008;12(2):135-9

    Sleep Med 2006,7:474-9

    Sleep 2006;29(9):1203-9


Clinical and polisomnographic features of complex sleep apnea syndrome


Clinical and polisomnographic features of complex sleep apnea syndrome


Clinical and polisomnographic features of complex sleep apnea syndrome


Clinical and polisomnographic features of complex sleep apnea syndrome


Pathophysiology of compsas
Pathophysiology of CompSAS ??? those of OSAS, while the breathing patterns resemble to those of Central Sleep Apnea (CSA)

  • Dysregulation of CO2 homeostasis

  • Instability in respiratory and/or cardiovascular control

  • Variations in baroreflex sensitivity

    Curr Opin Pulm Med 2005;11:485-93

    Sleep Med 2006;7:474-79


Treatment
Treatment those of OSAS, while the breathing patterns resemble to those of Central Sleep Apnea (CSA)

* The optimal treatment of CompSAS is not known

  • Positive Airway Pressure (PAP) therapy

  • Supplement oxygen

  • Pharmcotherapy

  • Minimizing of hypocapnia

    Curr Opin Pulm Med 2005;11:485-93


Clinical and polisomnographic features of complex sleep apnea syndrome


Clinical and polisomnographic features of complex sleep apnea syndrome


Clinical and polisomnographic features of complex sleep apnea syndrome


Clinical and polisomnographic features of complex sleep apnea syndrome


Clinical and polisomnographic features of complex sleep apnea syndrome


Clinical and polisomnographic features of complex sleep apnea syndrome

  • Positive Airway Pressure (PAP) therapy reduces the number of central respiratory events and decreases the overnight sympathetic activity in CHF-CSA patients

  • Supplement oxygen

  • Pharmcotherapy

  • Minimizing hypocapnia


Clinical and polisomnographic features of complex sleep apnea syndrome

  • Theophylline reduces the number of central respiratory events and decreases the overnight sympathetic activity in CHF-CSA patients

  • Tyroksine

  • Metroksyprogesterone

  • Acetazolamide


Clinical and polisomnographic features of complex sleep apnea syndrome

  • Positive Airway Pressure (PAP) therapy reduces the number of central respiratory events and decreases the overnight sympathetic activity in CHF-CSA patients

  • Supplement oxygen

  • Pharmcotherapy

  • Minimizing hypocapnia


Clinical and polisomnographic features of complex sleep apnea syndrome

  • Added Dead Space reduces the number of central respiratory events and decreases the overnight sympathetic activity in CHF-CSA patients

    Chest 2003;123:1551-60


Objective
Objective reduces the number of central respiratory events and decreases the overnight sympathetic activity in CHF-CSA patients

  • To compare clinical and polisomnographic (PSG) features between with OSAS and CompSAS


Method
Method reduces the number of central respiratory events and decreases the overnight sympathetic activity in CHF-CSA patients

  • Polisomnographic records evaluated a total of 270 patients, retrospectively

  • CPAP titration was prescribed in patients with AHI ≥15

  • Patients who developed a central AHI ≥ 5 following titration PSG are diagnosed as CompSAS.


Results
Results reduces the number of central respiratory events and decreases the overnight sympathetic activity in CHF-CSA patients

  • There were 258 patients with OSAS and 12 with CompSAS

  • CPAP titration was prescribed in 83 cases


Discussion
Discussion reduces the number of central respiratory events and decreases the overnight sympathetic activity in CHF-CSA patients

  • The results of our study revealed that;

    • The rate of CHF was significantly higher, the lower average and minimum values of oxygen saturation in diagnostic PSG in group of CompSAS

    • Irregularity in the mechanisims of respiratory and/or cardiovascular control may be responsible in the pathophysiology of CompSAS according to above two results.