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Lenlaid (Lenalidomide) tablet treats anemia and multiple myeloma (cancer resulting from a progressive blood disease). Buy Lenalid 10mg is used in patients with myelodysplastic syndrome caused by an abnormal chromosome. This disorder is also called deletion 5q MDS, because part of chromosome 5 is missing.It was initially intended as a treatment for multiple myeloma, for which thalidomide is an accepted therapeutic treatment. Buy Lenalid 10mg has also shown efficacy in the class of hematological disorders known as myelodysplastic syndromes (MDS).

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Buy Lenalid 10 mg (Lenalidomide), Lenalidomide is used in adults in combina?on with other medicines to treat mul?ple

myeloma (a type of cancer which affects plasma cells, a certain type of white blood cell) and alone to treat myelodysplas?c

syndromes (collec?on of many different blood and bone marrow diseases). It is also used to treat mantle cell lymphoma

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DESCRIPTION

ADDITIONAL INFORMATION

REVIEWS (0)

Lenalid 10 mg

(h?ps://www.alldaygeneric.com)

(Lenalidomide)

Uses of Lenalid

Lenalidomide is used in adults in combina?on with other medicines to treat mul?ple myeloma (a type of cancer

which affects plasma cells, a certain type of white blood cell) and alone to treat myelodysplas?c syndromes

(collec?on of many different blood and bone marrow diseases). It is also used to treat mantle cell lymphoma

(aggressive variety of cancer that occurs in lymph nodes).

How Lenalid works

Lenalidomide is an immunomodulatory and an an?angiogenic agent. It works by stopping the growth of cancer

cells in the body.

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Mode of ac?on

Lenalidomide has been used to successfully treat both inflammatory disorders and cancers in the past 15 years.

There are mul?ple mechanisms of ac?on, and they can be simplified by organizing them as mechanisms of ac?on

in vitro and in vivo. In vitro, cheap lenalidomide has three main ac?vi?es: direct an?-tumor effect, inhibi?on of

the microenvironment support for tumor cells, and immunomodulatory role. In vivo, Buy lenalidomide induces

tumor cell apoptosis directly and indirectly by inhibi?on of bone marrow stromal cell support, by an?-angiogenic

and an?-osteoclastogenic effects, and by immunomodulatory ac?vity.Lenalidomide has a broad range of ac?vi?es

that can be exploited to treat many hematologic and solid cancers.

The proposed mechanisms of ac?on of lenalidomide in mul?ple myeloma

The proposed mechanisms of ac?on of lenalidomide in mul?ple myeloma (MM) include direct cytotoxicity via

induc?on of apoptosis (A); inhibi?on of cell adhesion molecules such as intercellular adhesion molecule 1 (ICAM-

1) and vascular cell adhesion molecule 1 (VCAM-1), which reduces the growth signaling of MM cells (B); inhibi?on

of growth signals that promote bone marrow angiogenesis, such as vascular endothelial growth factor (VEGF),

tumor necrosis factor α (TNF-α), and interleukin (IL)-6 (C); and s?mula?on of the T-helper cells, which increases

produc?on of IL-2 and interferon-γ (IFN-γ) and consequently augments natural killer (NK) cell ac?va?on and NK

cell-dependent cytotoxicity (D). Illustra?on by Taina Litwak, CMI.

Treatment of mul?ple myeloma.

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Mul?ple myeloma is a cancer of the blood, characterized by accumula?on of a plasma cell clone in the bone

marrow. Lenalidomide is one of the novel drug agents used to treat mul?ple myeloma. It is a small molecular

analog of thalidomide that was originally found based on its ability to effec?vely inhibit tumor necrosis factor

produc?on. Lenalidomide is 50,000 ?mes more potent than thalidomide in inhibi?ng tumor necrosis factor-alpha,

and has less severe adverse drug reac?ons. In a phase III clinical study, Weber et al. found that lenalidomide plus

dexamethasone in pa?ents with relapsed or refractory mul?ple myeloma was superior to the old treatment of

mul?ple myeloma consis?ng of high-dose dexamethasone alone.

Dosage of Lenalid

Always follow the instruc?ons of doctor regarding the dosage and dura?on.

• Mul?ple Myeloma and mantle cell lymphoma: 25 mg/day on days 1 through 21 of repeated 28 day cycles.

• Myelodysplas?c Diseases: 10 mg once daily.

• This informa?on is not intended as medical advice for individual condi?ons or treatment. It is not a subs?tute

for a medical exam, nor does it replace the need for services provided by medical professionals. Talk to your

doctor, nurse or pharmacist before taking any prescrip?on or over the counter drugs (including any herbal

medicines or supplements) or following any treatment or regimen. Only your doctor, nurse, or pharmacist can

provide you with advice on what is safe and effec?ve for you.

Common side effects

Anemia, low levels of calcium, phosphate, potassium or magnesium in the blood, iron overload, changes to blood

thyroid hormone, vasculi?s (changes to a protein in the blood that can cause swelling of the arteries), muscle

cramps, muscle aches and weakness, bone/ joint pain, pains in hands or feet, ?redness, generalized swelling,

numbness, ?ngling or burning sensa?on, fever and flu, cons?pa?on, stomach pain, diarrhea, nausea, vomi?ng,

decreased appe?te, bleeding from the gums, stomach, or bowels, kidney problems, dehydra?on, sore inflamed

mouth, dry mouth, difficulty swallowing, heartburn, abnormal liver test results, chest pain or shortness of breath,

high or low blood pressure, irregular heartbeat, heart problems, increased swea?ng, depression, dizziness,

fain?ng, confusion, mood change, difficulty sleeping, tremor, impaired balance, movement difficulty, dry skin,

darkening of skin, skin erup?ons, skin cracking, flaking or peeling skin, hives, itching redness of skin, rashes,

blurred vision, cataract, ?nnitus (ringing in the ears), deafness, toothache, weight loss, diabetes.

Who should not take

• Pa?ents who are allergic to lenalidomide or any of its ingredients.

• Children or adolescents under 18 years of age.

• Pregnant or breas?eeding women.

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Lenalidomide is a deriva?ve of thalidomide introduced in 2004. It was ini?ally intended as a treatment for

mul?ple myeloma, for which thalidomide is an accepted therapeu?c treatment. Lenalidomide has also shown

efficacy in the class of hematological disorders known as myelodysplas?c syndromes (MDS). Lenalidomide has

significantly improved overall survival in myeloma (which generally carries a poor prognosis), although toxicity

remains an issue for users.

What is Lenalid?

Lenalid is Generic version of Revlimid manufactured by Natco which is manufactured by Natco Pharma Ltd.

(INDIA)

Lenalid is used for treatment of a certain type of myelodysplas?c syndrome (a group of condi?ons in which the

bone marrow produces blood cells that are misshapen and does not produce enough healthy blood cells) caused

by an abnormal chromosome. Lenalid is also used for treatment of anemia (a lack of red blood cells in the body)

and along with dexamethasone for the treatment of mul?ple myeloma (a type of cancer of the bone marrow)

who have received at least one prior therapy.

What are the Indica?ons of Lenalid?

• Mul?ple Myeloma: Lenalidomide in combina?on with dexamethasone is indicated for the treatment of pa?ents

with mul?ple myeloma (MM) who have received at least one prior therapy.

• Myelodysplas?c Syndromes: Lenalidomide is indicated for the treatment of pa?ents with transfusion-dependent

anemia due to low-or intermediate-1-risk myelodysplas?c syndromes (MDS) associated with a dele?on 5q

cytogene?c abnormality with or without addi?onal cytogene?c abnormali?es.

• Mantle Cell Lymphoma: Lenalidomide is indicated for the treatment of pa?ents with mantle cell lymphoma

(MCL) whose disease has relapsed or progressed a?er two prior therapies, one of which included bortezomib.

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Is Lanalid available in India?

Lanalid is a (prescrip?on drug, prescrip?on medica?on or prescrip?on medicine) pharmaceu?cal drug

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Cost of Lenalidomide Capsules Lenalid 10 in Australia, Brazil, China, Canada, Eqypt, Europe, France, Germany,

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Precau?ons

Before taking Lenalid (Lenalidomide) you must tell your physician if you are receiving dialysis, have a tumor,

cancer, or kidney problems.

It is extremely important that women do not become pregnant while taking this drug as it can cause birth defects

in unborn children. It can also be passed on through s**ual intercourse with a man who is taking the medica?on.

Make sure to always use precau?ons when having s**ual intercourse with pregnant women when taking this

drug.

Expert advice for Lenalid

• You may be monitored with regular blood tests before and during the treatment as lenalidomide may cause a

fall in the white blood cells and platelets, required to fight infec?on and blood clo?ng.

• Avoid ac?vi?es that may cause bruising or injury and avoid contact with people who have colds or infec?ons.

• You should not donate blood, semen or serum during treatment and for 4 week a?er the end of treatment.

• You may be at risk of developing acute myelogenous leukemia, Hodgkin lymphoma tumor lysis syndrome, fatal

liver problems, severe skin reac?ons and fatal heart problems during treatment with lenalidomide. You should

discuss in advance the benefits and risks of taking lenalidomide.

• Lenalidomide is not recommended for use in children and adolescents under 18 years.

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• You should use proper contracep?ve methods at least 4 weeks before, during and un?l 4 weeks a?er stopping

treatment.

• Woman of childbearing poten?al will be required to undergo pregnancy tests before, every 4 weeks and a?er

the treatment.

• You should inform your doctor or den?st that you take lenalidomide before you receive any medical or dental

care, emergency care, or surgery.

• Do not drive or operate machines while taking lenalidomide as it may make you feel dizzy, ?red, sleepy or have

blurred vision.

Frequently asked ques?ons for Lenalid

Lenalidomide

Q. What is lenalidomide/ What is lenalidomide used for / is lenalidomide a chemotherapy drug/ a cytotoxic?

Lenalidomide an immunomodulatory and an an?angiogenic agent andis used to treat mul?ple myeloma,

myelodysplas?c syndromes and mantle cell lymphoma in certain pa?ents. It is a chemotherapy-like drug and has

the same cytotoxic effects as chemotherapy drugs as in to kill myeloma cells but the mechanism of ac?on is

different.

Q. How is lenalidomide administered?

Lenalidomide is administered orally as a capsule.

Q. How does lenalidomide work?

Lenalidomide works by affec?ng the body’s immune system and directly a?acking the cancer cells.

Q. Does lenalidomide cause hair loss?

Hair loss could be a side effect of using lenalidomide. Always consult your doctor before its use.

Disclaimer

We provide only general informa?on about medica?ons which does not cover all direc?ons, possible drug

integra?ons, or precau?ons. Informa?on at the site cannot be used for self-treatment and self-diagnosis. Any

specific instruc?ons for a par?cular pa?ent should be agreed with your health care adviser or doctor in charge of

the case. We disclaim reliability of this informa?on and mistakes it could contain. We are not responsible for any

direct, indirect, special or other indirect damage as a result of any use of the informa?on on this site and also for

consequences of self-treatment.

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