Paramyxoviiruses. September 21,22, 2010. rinderpest and the beginning of modern veterinary medicine. Giovanni Maria Lancisi. Viruses with -ve RNA genomes. influenzaviruses. Orthomyxoviridae. parainfluenza virus. Paramyxoviruses. Newcastle disease virus. respiratory syncytial virus.
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September 21,22, 2010
Giovanni Maria Lancisi
Newcastle disease virus
vesicular stomatitis virus
asymptomatic incubation period (7-10 days)
GI and respiratory signs, infection of epithelial cells
acute neurological signs
chronic neurological signs
“old dog encephalitis”
In December a 4-5 month old American Pitbull cross was brought to a Saskatoon animal shelter as a stray. The puppy was vaccinated with DA2PCPV and was adopted out on December 23. The puppy was returned to the shelter on December 29 as he was coughing. On January 3, the attendant described the pup as acting weird - head pressing, stumbling and twitching were observed.
Within the next week several dogs at the shelter developed respiratory signs.
For the next several days about 10 dogs a day were brought to the WCVM clinic with signs of distemper. All dogs at the shelter were euthanised and it was closed for traffic.
5,000 samples from 46 species - negative
Antibodies in fruit bats
Virus isolatedDiagnostic investigation
Moved to paddock
Mare develops respiratory distress, ataxia, edema ->dies
Stallion in next paddock, neuro. Signs, haemorrhages ->dies
Owner (vet) and husband perform necropsyAt a farm near MacKay (July 1994)
Neuro signs, seizures
Treated with acyclovir, antibiotics, anticonvulsants, corticosteroids
Coma - dies three weeks later
CSF from 1994 - 1/4 for EMV, virus by PCR
In 1995, increase in titre from 1/16 to 1/5792
Necrosis in neocortex, basal brain, brain stem, cerebellumMacKay September 1995
Oct ‘98 to April ‘99 - 257 cases of encephalitis (100 deaths)
Similar disease in pigs
Trembling, head pressing, spasms
Abortions, still birthsPorcine respiratory encephalitis syndrome, barking pig syndrome
Serological evidence in fruit bats (reservoir?)
virus from fruit bats - 2002
2004-5 - human cases in Bangladesh (no contact with pigs or bats, contaminated fruit?)Nipah virus
Chou. Nipah virus outbreak in Malaysia. J Clin Virol April 2003
1 million pigs killed
reduce pig-human contact